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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 3 | Prevalence of cholelithiasis in patients with chronic inflammatory bowel disease显示文摘AIM: To investigate the effect of chronic inflammatory bowel disease (CIBD) specific risk factors for cholecystolithiasis,as duration and involvement pattern of the disease and prior surgery in patients with Crohn's disease (CD) and ulcerative colitis (UC).METHODS: A total of 222 patients with CD (135 females,87 males; average age, 35.8±11.8 years; range 17-81 years)and 88 patients with UC (39 females, 49 males; average age, 37.2±13.6 years; range 16-81 years) underwent clinical and ultrasound examinations. Besides age, sex and degree of obesity, patients' CIBD specific parameters, including duration and extent of disease and prior operations were documented and evaluated statistically using logistic regression.RESULTS: The overall prevalence of gallbladder stone disease in patients with CD was 13% (n = 30). Only age could be shown to be an independent risk factor (P = 0.014).Compared to a collective representative for the general population in the same geographic region, the prevalence of cholecystolithiasis was higher in all corresponding age groups. Patients with UC showed an overall prevalence of gallbladder stone disease of only 4.6%.CONCLUSION:Only age but not disease-specific factors such as duration and extent of disease, and prior surgery are independent risk factors for the development of cholecystolithiasis in patients with CIBD. | Wolfgang Kratzer Mark M Haenle Richard A Mason Christian von Tirpitz Volker Kaechele | 2005 | World Journal of Gastroenterology2005，11，39： | 3 |
| 4 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 5 | Biotransformation of S-Triaxine herbicides and related degradation products in liquid cultures by the white rot fungus Phanerochaete chrysosporium显示文摘 | CHRISTIAN M CHANTAL L MARCEL A T | 1997 | Pestie Sci1997，49，： | 1 |
| 6 | Grapefurit juice activates P-glycoprotein-mediated drug transport 显示文摘 | Soldner A Christians U Susanto M | 1999 | Pharm Res1999，16，： | 1 |
| 7 | A vector - perturbation technique for near - capacity multi antenna mul- tiuser communication part II : perturbation 显示文摘 | BERTRAND M H CHRISTIAN B P LEE S A | 2005 | Communica- tions IEEE Transactions2005，53，7： | 1 |
| 8 | Mechanistic in- vestigation of the anodic oxidation of 3,4,5-trimethoxy- toluene in acetonitrile 显示文摘 | Ayoub H S Fatma M M Christian A | 2002 | J Electroanal Chem2002，537，： | 1 |
| 9 | Bovine im- mune response to shiga-toxigenic Escherichia coli O157 : H7 显示文摘 | MARK A H CHRISTIAN M THOMAS A C | 2006 | Clinical Vaccine Immunology2006，11，： | 1 |
| 10 | A vector - perturbation technique for near - capacity multi antenna mul- tiuser communication Part I : channel inversion and regulari- zation 显示文摘 | BERTRAND M H CHRISTIAN B P A LEE S | 2005 | IEEE Transactions on Communication2005，53，9： | 1 |
| 11 | A new approach to crystal- lographic orientation measurement for apatite fission track analysis, Effects of crystal morphology and implications for automation显示文摘 | Peternell M Kotdmann Fabian Wilson C J L Seiler Christian Gleadow A J W | 2009 | Chemical Geology2009，265，： | 1 |
| 12 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 13 | Work en- gagement :A quantitative review and test of its rela- tions with task and contextual performance 显示文摘 | Christian M S Garza A S Slaughter J E | 2011 | Per- sonnel Psychology2011，64，1： | 1 |
| 14 | Mechanistic in- vestigation of the anodic oxidation of p-methoxytoluene in dry and wet acetonitrile 显示文摘 | Ayoub H S Fatma M M Christian A | 1999 | J Electroanal Chem1999，464，： | 1 |
| 15 | Myxobolus cerebralis: identification of a cathepsin Z-like protease gene ( MyxCP - 1 ) expressed during parasite developmem in rainbow trout, Oncorhynchus mylviss 显示文摘 | Garry O Kelley Mark A Adkison Christian M Leutenegger | 2003 | Experimental Parasitology2003，105，34： | 1 |
| 16 | Identification of a Thymidylate Synthase Gene within the Genome of Chilo Iridescent Virus 显示文摘 | Christian A Tidona U | 1998 | Virus Genes1998，17，3： | 1 |
| 17 | A continuum model for a re-entrant factory显示文摘 | Dieter A Dan M Christian R | 2006 | Operation Research2006，54，5： | 1 |
| 18 | Magnetic resonance classification of lumbar intervertebral disc degeneration显示文摘 | Christian W A P Alexander M Marco Z | 2001 | Spine2001，26，17： | 1 |
| 19 | Source separation and tracking for time-varying sys- tems显示文摘 | CHRISTIAN M C PETER A Y LEON H S | 2008 | Aerospace and Electronic Systems2008，44，3： | 1 |
| 20 | Effective primary isolation of wild-type Canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes显示文摘 | John A Lednicky Thomas P Meehan Michael J Kinsel Jean Dubach Laura L Hungerford Nicolene A Sarich Kelley E Witecki Michael D Braid Casandra Pedrak Christiane M Houde | 2004 | Journal of Virological Methods2004，，2： | 1 |
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