|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pro?ling and Validation of the Circular RNA Repertoire in Adult Murine Hearts显示文摘For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes(e.g., cardiomyopathy) and we are just beginning to understand the relevant genetic factors. Several studies have related RNA splicing to cardiovascular disease and circular RNAs(circ RNAs) are an emerging player. circ RNAs, which originate through back-splicing events from primary transcripts, are resistant to exonucleases and typically not polyadenylated. Initial functional studies show clear phenotypic outcomes for selected circ RNAs. We provide, for the ?rst time, a comprehensive catalogue of RNase R-resistant circ RNA species for the adult murine heart. This work combines state-of-the-art circle sequencing with our novel DCC software to explore the circ RNA landscape of heart tissue.Overall, we identi?ed 575 circ RNA species that pass a beta-binomial test for enrichment(false discovery rate of 1%) in the exonuclease-treated sequencing sample. Several circ RNAs can be directly attributed to host genes that have been previously described as associated with cardiovascular disease. Further studies of these candidate circ RNAs may reveal disease-relevant properties or functions of speci?c circ RNAs. | Tobias Jakobi Lisa F. Czaja-Hasse Richard Reinhardt Christoph Dieterich | 2016 | Genomics, Proteomics & Bioinformatics2016，14，4： | 13 |
| 2 | Comparative Analysis of Expressed Sequence Tag (EST) Libraries in the Seagrass Zostera marina Subjected to Temperature Stress显示文摘 | Thorsten B. H. Reusch Amelie S. Veron Christoph Preuss January Weiner Lothar Wissler Alfred Beck Sven Klages Michael Kube Richard Reinhardt Erich Bornberg-Bauer | 2008 | Marine Biotechnology2008，，3： | 1 |
| 3 | Ischemic Preconditioning May Be Transferable via Whole Blood Transfusion: Preliminary Evidence显示文摘 | Eric W. Dickson Christopher P. Reinhardt Francis P. Renzi Richard C. Becker William A. Porcaro Stephen O. Heard | 1999 | Journal of Thrombosis and Thrombolysis1999，，2： | 1 |
| 4 | Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment显示文摘In their recent study published in Nature,Yuan and colleagues enlighten the role of histone lysine crotonylation(Kcr)in brain tumor biology.They report a novel lysine-dependent mechanism through which glioblastoma stem cells modulate type I interferon(IFNα/IFNβ)signaling to create an immunosuppressive environment. | Désirée Gül Oliver H.Krämer Christoph Reinhardt | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 5 | Tip-and Laser-based 3D Nanofabrication in Extended Macroscopic Working Areas显示文摘The field of optical lithography is subject to intense research and has gained enormous improvement.However,the effort necessary for creating structures at the size of 20 nm and below is considerable using conventional technologies.This effort and the resulting financial requirements can only be tackled by few global companies and thus a paradigm change for the semiconductor industry is conceivable:custom design and solutions for specific applications will dominate future development(Fritze in:Panning EM,Liddle JA(eds)Novel patterning technologies.International society for optics and photonics.SPIE,Bellingham,2021.http://gffzzd3cc09b8251d45dfsvfx9u9q59v9v6x90.ffgz.tsg.suse.edu.cn/10.1117/12.2593229).For this reason,new aspects arise for future lithography,which is why enormous effort has been directed to the development of alternative fabrication technologies.Yet,the technologies emerging from this process,which are promising for coping with the current resolution and accuracy challenges,are only demonstrated as a proof-of-concept on a lab scale of several square micrometers.Such scale is not adequate for the requirements of modern lithography;therefore,there is the need for new and alternative cross-scale solutions to further advance the possibilities of unconventional nanotechnologies.Similar challenges arise because of the technical progress in various other fields,realizing new and unique functionalities based on nanoscale effects,e.g.,in nanophotonics,quantum computing,energy harvesting,and life sciences.Experimental platforms for basic research in the field of scale-spanning nanomeasuring and nanofabrication are necessary for these tasks,which are available at the Technische Universitiit Ilmenau in the form of nanopositioning and nanomeasuring(NPM)machines.With this equipment,the limits of technical structurability are explored for high-performance tip-based and laser-based processes for enabling real 3D nanofabrication with the highest precision in an adequate working range of several thousand cubic millimeters. | Ingo Ortlepp Thomas Frohlich Roland FuBl Johann Reger Christoph Schaffel Stefan Sinzinger Steffen Strehle ReneTheska Lena Zentner Jens-Peter Zollner Ivo WRangelow Carsten Reinhardt Tino Hausotte Xinrui Cao Oliver Dannberg Florian Fern David Fischer Stephan Gorges Martin Hofmann Johannes Kirchner Andreas Meister Taras Sasiuk Ralf Schienbein Shraddha Supreeti Laura Mohr-Weidenfeller Christoph Weise Christoph Reuter Jaqueline Stauffenberg Eberhard Manske | 2021 | Nanomanufacturing and Metrology2021，4，3： | 0 |
| 6 | Restricted nutrient intake does not alter serum-mediated measures of implant response in cell culture显示文摘Background: During nutritional stress, reduced intake may reduce the efficacy of anabolic implants. This study was conducted to evaluate basic cellular responses to a growth promotant implant at two intake levels.Methods: Sixteen crossbred steers(293 ± 19.3 kg) were used to evaluate the impact of anabolic implants in either an adequate or a restricted nutritional state. Steers were trained to individual Calan gates, and then randomly assigned to 1 of 4 treatments in a 2 × 2 factorial arrangement. Treatments consisted of: presence or absence of an anabolic growth implant(Revalor-XS, 200 mg TBA and 40 mg estradiol; IMPLANT or CONTROL) and a moderate energy, pelleted, starting cattle diet fed at either 2.0 × or 1.0 × maintenance energy(NEM) requirements(HIGH or LOW). Serum(d 0, 14, and 28) was used for application to bovine muscle satellite cells. After treatment with the serum(20% of total media) from the trial cattle, the satellite cells were incubated for 72 h. Protein abundance of myosin heavy chain(MHC), phosphorylated extracellular signal-related kinase(phospho-ERK), and phosphorylated mammalian target of rapamycin(phospho-mTOR) were analyzed to determine the effects of implant, intake, and their interaction(applied via the serum).Results: Intake had no effect on MHC(P = 0.85) but IMPLANT increased(P < 0.01) MHC abundance vs. CONTROL.Implant status, intake status, and the interaction had no effect on the abundance of phospho-ERK(P ≥ 0.23).Implanting increased phospho-mTOR(P < 0.01) but there was no effect(P ≥ 0.51) of intake or intake × implant.Conclusions: The nearly complete lack of interaction between implant and nutritional status indicates that the signaling molecules measured herein respond to implants and nutritional status independently. Furthermore, results suggest that the muscle hypertrophic effects of anabolic implants may not be mediated by circulating IGF-1. | Christopher D Reinhardt Tiffany L Lee Daniel U Thomson Laman K Mamedova Barry J Bradford | 2014 | Journal of Animal Science and Biotechnology2014，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员