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| 1 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 2 | Repeated Multiview Imaging for Estimating Seedling Tiller Counts of Wheat Genotypes Using Drones显示文摘Early generation breeding nurseries with thousands of genotypes in single-row plots are well suited to capitalize on high throughput phenotyping.Nevertheless,methods to monitor the intrinsically hard-to-phenotype early development of wheat are yet rare.We aimed to develop proxy measures for the rate of plant emergence,the number of tillers,and the beginning of stem elongation using drone-based imagery.We used RGB images(ground sampling distance of 3mm pixel-1)acquired by repeated flights(≥2 flights per week)to quantify temporal changes of visible leaf area.To exploit the information contained in the multitude of viewing angles within the RGB images,we processed them to multiview ground cover images showing plant pixel fractions.Based on these images,we trained a support vector machine for the beginning of stem elongation(GS30).Using the GS30 as key point,we subsequently extracted plant and tiller counts using a watershed algorithm and growth modeling,respectively.Our results show that determination coefficients of predictions are moderate for plant count(R^(2)=0:52),but strong for tiller count(R^(2)=0:86)and GS30(R^(2)=0:77).Heritabilities are superior to manual measurements for plant count and tiller count,but inferior for GS30 measurements.Increasing the selection intensity due to throughput may overcome this limitation.Multiview image traits can replace hand measurements with high efficiency(85-223%).We therefore conclude that multiview images have a high potential to become a standard tool in plant phenomics. | Lukas Roth Moritz Camenzind Helge Aasen Lukas Kronenberg Christoph Barendregt Karl-Heinz Camp Achim Walter Norbert Kirchgessner Andreas Hund | 2020 | Plant Phenomics2020，2，1： | 2 |
| 3 | A Laboratory Model to Evaluate Cutout Resistance of Implants for Pertrochanteric Fracture Fixation显示文摘 | Mark B. Sommers Christoph Roth H. Hall Benjamin C. C. Kam Larry W. Ehmke James C. Krieg Steven M. Madey Michael Bottlang | 2004 | Journal of Orthopaedic Trauma2004，，6： | 2 |
| 4 | Effect of cultivation parameters on growth and pigment biosynthesis in flagellated cells of Haematococcus pluvialis显示文摘 | Christoph Hagen Kay Grünewald Marco Xyl?nder Eva Rothe | 2001 | Journal of Applied Phycology2001，，1： | 1 |
| 5 | An integrated shadow-mask based on a stack of imorganic insnlators for high-resolution OLEDs using evaporated or spun-on material显示文摘 | Christophe P Dan Roth Isabelle Le'vesque | 2001 | Synthetic Metals2001，122，： | 1 |
| 6 | HgTe量子阱中的量子自旋霍尔绝缘态显示文摘近来,理论研究预言量子霍尔效应,在外加磁场为0的情况下物质出现的一种全新的量子态可以在HgTe/(Hg,Cd)Te量子阱中实现。我们制造了低密度高迁移率的样品结构,在样品中我们可以通过外加栅极电压调节载流子从n型穿过绝缘区到p型。对于宽度d<6.3nm的薄量子阱,绝缘区在低温下具有常规的难以察觉的微小电导。然而,对于厚的量子阱(d>6.3nm),在绝缘层中也出现接近2e2/h的剩余电导,其中e是电子电荷,h是Planck常数.剩余电导与样品宽度无关,证明这是由边缘态引起的.此外剩余电导可以被微小的外加磁场所破坏.在临界厚度d=6.3nm处发生的量子相变也与磁场诱发的绝缘-金属转变互相独立.这些观察结果为量子自旋霍尔效应提供了实验证据。 | Markus Konig Steffen Wiedmann Christoph Brüne Andreas Roth Hartmut Buhmann Laurens W.Molenkamp 黄光耀 赵安 | 2007 | 中山大学研究生学刊(自然科学与医学版)2007，28，4： | 1 |
| 7 | Phillips-Perron-type unit root tests in the nonlinear ESTAR framework显示文摘 | Christoph Rothe Philipp Sibbertsen | 2006 | Allgemeines Statistisehes Archiv2006，，： | 1 |
| 8 | An integrated shadow-mask based on a stack of inorganic insulators for high-resolution OLEDs using evaporated or spun-on materials显示文摘 | Christophe Py Dan Roth Isabelle Lévesque | 2001 | Synthetic Metals2001，122，1： | 1 |
| 9 | Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks显示文摘The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection.To define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering analyses.In our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies.The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19.Changes within this sign ature were associated with either disease progression or recovery.In summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity. | Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 10 | Practical aspects of fast reversed-phase high-performance liquid chromatography using 3μm particle packed columns and monolithic columns in pharmaceutical development and production working under current good manufacturing practice显示文摘 | Frederic Gerber Markus Krummen Heiko Potgeter Alfons Roth Christoph Siffrin Christoph Spoendlin | 2004 | Journal of Chromatography A2004，，2： | 1 |
| 11 | The Global Burden of Ischemic Heart Disease in 1990 and 2010: The Global Burden of Disease 2010 Study显示文摘 | Andrew E. Moran Mohammad H. Forouzanfar Gregory A. Roth George A. Mensah Majid Ezzati Abraham Flaxman Christopher J.L. Murray Mohsen Naghavi | 2014 | Circulation2014，，： | 1 |
| 12 | A laboratory model to evaluate cutout resistance of implants for pertrochanteric fracture显示文摘 | Sommers MB Roth Christoph MS Hall HMS | 2004 | Fixation Volume2004，18，6： | 1 |
| 13 | The viral mimetic polyinosinic:polycytidylic acid (poly I:C) induces cellular responses in primary cultures from rat brain sites with an incomplete blood–brain barrier显示文摘 | Daniela Ott Florian Wuchert Jolanta Murgott Christoph Rummel Rüdiger Gerstberger Joachim Roth | 2012 | Neuroscience Letters2012，，1： | 1 |
| 14 | Assessment of STAN S21 fetal heart monitor by medical staff显示文摘 | Sebastien Rault Christophe Vayssiere Emmanuel Roth Eric David Romain Favre Bruno Langer | 2008 | International Journal of Gynecology and Obstetrics2008，，1： | 1 |
| 15 | Patent Misuse- the Critical Balance: A Patent Lawyer's View显示文摘 | Joe Potenza Phillip Bennett and Christopher Roth | 2005 | The Federal Circuit Bar Journal2005，15，： | 1 |
| 16 | Copeptin Improves Early Diagnosis of Acute Myocardial Infarction显示文摘 | Till Keller Stergios Tzikas Tanja Zeller Ewa Czyz Lars Lillpopp Francisco M. Ojeda Alexander Roth Christoph Bickel Stephan Baldus Christoph R. Sinning Philipp S. Wild Edith Lubos Dirk Peetz Jan Kunde Oliver Hartmann Andreas Bergmann Felix Post Karl J. Lac | 2010 | Journal of the American College of Cardiology2010，，19： | 1 |
| 17 | A Novel Application of the MIRC Repository in Medical Education显示文摘 | Christopher J. Roth M.D. William J. Weadock M.D. Michael A. DiPietro M.D | 2005 | Journal of Digital Imaging2005，，2： | 1 |
| 18 | Evolution of insomnia: current status and future direction显示文摘 | Thomas Roth Christopher Drake | 2004 | Sleep Medicine2004，，： | 1 |
| 19 | Effect of cultivation parameters on growth and pigment biosynthesis in flagellated cells of Haematococcus pluvialis显示文摘 | Christoph Hagen Kay Grünewald Marco Xyl?nder Eva Rothe | 2001 | Journal of Applied Phycology2001，，1： | 1 |
| 20 | Suppliers’ perception of destination competitiveness in a winter sport resort显示文摘 | Kirstin Hallmann Sabine Müller Svenja Feiler Christoph Breuer Ralf Roth | 2012 | Tourism Review2012，，： | 1 |
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