6篇
您的检索式：作者名="Christopher J Ward"
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| 1 | Evidence of linkage disequilibrium in the Spanish polycystic kidney diseaseⅠpopulation显示文摘 | Belen peral Christopher J Ward Jose L S M | 1994 | Am J Hum Genet1994，54，： | 1 |
| 2 | Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis显示文摘 | Christopher J Sinal Masahiro Tohkin Masaaki Miyata Jerrold M Ward Gilles Lambert Frank J Gonzalez | 2000 | Cell2000，，6： | 1 |
| 3 | A novel algorithm and architecture for adaptive digital beamforming显示文摘 | Christopher Ward Philip J Hargrave John G Mcwhirter | 1986 | IEEE Trans On AP1986，34，3： | 1 |
| 4 | Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial显示文摘 | Christopher E Brightling William Monteiro Richard Ward Debbie Parker Michael DL Morgan Andrew J Wardlaw Ian D Pavord | 2000 | The Lancet2000，，9240： | 1 |
| 5 | 用于降低能耗和控制二氧化碳排放的铁路车辆模型开发与应用显示文摘为助力英国2050年前实现碳中和目标,铁路运输线路将全面实现电气化。这期间,英国应采用其他措施以降低铁路运输碳强度。本文运用MATLAB/Simulink开发了一种Class 800型双模动力列车的详细模型,并根据英格兰西南部全天铁路运行获得的数据对该模型进行了验证。基于经验证的列车模型分析不同电气化比例线路对二氧化碳排放的影响,及制定降低列车二氧化碳排放的控制措施。结果表明,当列车运行在一条典型线路时,通过自主调节限速控制与发动机选择性关闭相结合的方法可减少二氧化碳排放19.1%。同时,运用该模型调查(间歇性/非连续性)线路电气化排放效率表明,线路全面电气化可使二氧化碳排放量减少66%。 | Tim J Harrison William JB Midgley Roger M Goodall Christopher P Ward | 2023 | 智慧轨道交通2023，60，4： | 0 |
| 6 | Familial Alzheimer's disease modelling using induced pluripotent stem cell technology显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disease in which patients exhibit gradual loss of memory that impairs their ability to learn or carry out daily tasks.Diagnosis of AD is difficult,particularly in early stages of the disease,and largely consists of cognitive assessments,with only one in four patients being correctly diagnosed.Development of novel therapeutics for the treatment of AD has proved to be a lengthy,costly and relatively unproductive process with attrition rates of>90%.As a result,there are no cures for AD and few treatment options available for patients.Therefore,there is a pressing need for drug discovery platforms that can accurately and reproducibly mimic the AD phenotype and be amenable to high content screening applications.Here,we discuss the use of induced pluripotent stem cells(iPSCs),which can be derived from adult cells,as a method of recapitulation of AD phenotype in vitro.We assess their potential use in high content screening assays and the barriers that exist to realising their full potential in predictive efficacy,toxicology and disease modelling.At present,a number of limitations need to be addressed before the use of iPSC technology can be fully realised in AD therapeutic applications.However,whilst the use of AD-derived iPSCs in drug discovery remains a fledgling field,it is one with immense potential that is likely to reach fruition within the next few years. | Lisa Mohamet Natalie J Miazga Christopher M Ward | 2014 | World Journal of Stem Cells2014，6，2： | 0 |
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