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| 1 | Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection显示文摘 | Andreas Mas Marques Tobias Mueller Justus Welke Stefan Taube Christoph Sarrazin Manfred Wiese Juliane Halangk Heiko Witt Golo Ahlenstiel Ulrich Spengler Uwe Goebel Eckart Schott Viola Weich Beate Schlosser Hermann E. Wasmuth Frank Lammert Thomas Berg Ecka | 2009 | Infection, Genetics and Evolution2009，，5： | 1 |
| 2 | The effects of levetiracetam on congnition: A non-interventional surveillance study 显示文摘 | Christoph Helmstaedter Juri-Alexander Witt | 2008 | Epilepsy & Behavior2008，13，4： | 1 |
| 3 | Aberrant Neurogenesis After Stroke: A Retroviral Cell Labeling Study显示文摘 | Fanny Niv Silke Keiner -K Krishna Otto W. Witte Dieter Chichung Lie Christoph Redecker | 2012 | Stroke2012，，： | 1 |
| 4 | Induction of Neurogenesis in the Adult Dentate Gyrus by Cortical Spreading Depression显示文摘 | Anja Urbach Christoph Redecker and Otto Witte | 2008 | Stroke2008，39，： | 1 |
| 5 | Primary Angiitis of the Central Nervous System at Conventional Angiography显示文摘 | Yasha K Christopher J De Witte T | 2004 | Radiology2004，233，： | 1 |
| 6 | Empirical Analysis of the Yield Curve:The Information in the Data Viewed through the Windows of Cox,Ingersoll,and Ross显示文摘 | Christopher G Lamoureux H Douglas Witte | 2002 | The Journal of Finance2002，57，3： | 1 |
| 7 | Rehabilitative Therapies Differentially Alter Proliferation and Survival of Glial Cell Populations in the Perilesional Zone of Cortical Infarcts显示文摘卒中后的康复治疗能改善神经环路的重塑,促进功能恢复。但人们对其潜在的细胞分子机制却知之甚少。特别是康复训练对在大脑局部缺血的病理生理过程中扮演着重要角色的胶质细胞的影响,一直不甚明了。现在,作者设计一项实验来检测康复训练对光化学诱导的局灶性脑缺血损伤灶周围(梗死灶位于大鼠前肢感觉运动皮质功能区)的不同胶质细胞种群增殖和存活的影响。造模成功后,标准组小鼠即开始在标准笼中接受每日定期的针对损伤前肢的功能训练,强化组大鼠转移到强化环境中饲养,抓取组大鼠仍然放在标准笼中未给予进一步的治疗。作者通过感觉运动行走测试来评价功能恢复情况,并于梗死后2-6d给予BrdU以标记检测增殖的细胞。分贝在梗死后的第10天和第42天,用免疫细胞化学方法对病灶周围增殖和存活的星形胶质细胞、小胶质细胞/巨噬细胞和成熟或未成熟的少突胶质细胞进行定量检测。结果作者发现,强化环境和抓取训练都能显著提高损伤前肢的功能恢复程度。此外,这些治疗能显著减少梗死灶周围小胶质细胞/巨噬细胞的增殖,其中对损伤前肢的每日训练还能明显提高新生星形胶质细胞的存活率。因此,作者的数据证明,皮质梗死后的康复治疗不仅能促进功能恢复,而且显著影响着病灶周围区胶质细胞的反应。 | SILKE KEINER FANNY WURM ALBRECHT KUNZE OTTO W. WITTE AND CHRISTOPH REDECKER | 2008 | 神经损伤与功能重建2008，3，2： | 1 |
| 8 | Sequence-sorted redox-switchable hetero[3]rotaxanes显示文摘From a library of five crown ether macrocycles with different ring sizes and redox-active moieties,such as tetrathiafulvalene(TTF)and naphthalene dimiide(NDI),directional heterocircuit[3]rotaxanes were constructed.Using an axle with two binding sites with different steric accessibility,the concept of integrative self-sorting was applied to program the sequence of functional units in heteropseudo[3]rotaxanes.Depending on binding strength and ring size of the smaller macrocycles,different heteropseudo[3]rotaxane selectivities and stabilities were determined by 2D NMR spectroscopy and tandem mass spectrometry.A heteropseudo[3]rotaxane with rotaxane-like behaviour was isolated chromatographically,displaying electrochemically“frustrated”properties.A robust synthetic procedure was developed allowing the synthesis of four new hetero[3]rotaxanes incorporating specific sequences of functional units.Sequence pseudoisomeric rotaxanes which have the naphthalene diimide subunit at two different positions show distinct electrochemical properties.DFT calculations suggest that this differences could arise from a folding of the structure,in which the redox-active moieties stack with a stopper unit.This study presents a blueprint for the construction of hetero[3]rotaxanes with sequential control of the functional units along the track of the axle and paves the way to extend the functionality of mechanically interlocked molecules. | Marius Gaedke Henrik Hupatz Felix Witte Susanne M.Rupf Clara Douglas Hendrik V.Schröder Lukas Fischer Moritz Malischewski Beate Paulus Christoph A.Schalley | 2022 | Organic Chemistry Frontiers2022，9，1： | 0 |
| 9 | Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant显示文摘Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body environment.This necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical integrity.In this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite coating.Detailed analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field. | Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Majumder Frank Witte Jörg F.Löffler | 2024 | Journal of Magnesium and Alloys2024，12，1： | 0 |
| 10 | Phylogeny and sex chromosome evolution of Palaeognathae显示文摘Many paleognaths(ratites and tinamous) have a pair of homomorphic ZW sex chromosomes in contrast to the highly differentiated sex chromosomes of most other birds. To understand the evolutionary causes for the different tempos of sex chromosome evolution, we produced female genomes of 12 paleognathous species and reconstructed the phylogeny and the evolutionary history of paleognathous sex chromosomes.We uncovered that Palaeognathae sex chromosomes had undergone stepwise recombination suppression and formed a pattern of “evolutionary strata”. Nine of the 15 studied species’ sex chromosomes have maintained homologous recombination in their long pseudoautosomal regions extending more than half of the entire chromosome length. We found that in the older strata, the W chromosome suffered more serious functional gene loss. Their homologous Z-linked regions, compared with other genomic regions, have produced an excess of species-specific autosomal duplicated genes that evolved female-specific expression, in contrast to their broadly expressed progenitors. We speculate such “defeminization” of Z chromosome with underrepresentation of female-biased genes and slow divergence of sex chromosomes of paleognaths might be related to their distinctive mode of sexual selection targeting females rather than males, which evolved in their common ancestors. | Zongji Wang Jilin Zhang Xiaoman Xu Christopher Witt Yuan Deng Guangji Chen Guanliang Meng Shaohong Feng Luohao Xu Tamas Szekely Guojie Zhang Qi Zhou | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
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