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| 1 | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery显示文摘Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as PTFE.While collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery.Thus,biodegradable GBR membranes made of pure magnesium might be an alternative.In this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective.After implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft tissue.During the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect space.As the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier capabilities.During the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new bone.After the membrane had completely resorbed,only healthy tissue remained.The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane.Overall,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. | Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte | 2022 | Bioactive Materials2022，7，8： | 7 |
| 2 | The history of biodegradable magnesium implants: A review显示文摘 | Frank Witte | 2010 | Acta Biomaterialia2010，，5： | 5 |
| 3 | The history of biodegradable magnesium implants: A review显示文摘 | Frank Witte | 2010 | Acta Biomaterialia2010，，5： | 3 |
| 4 | Degradable biomaterials based on magnesium corrosion显示文摘 | Frank Witte Norbert Hort Carla Vogt Smadar Cohen Karl Ulrich Kainer Regine Willumeit Frank Feyerabend | 2009 | Current Opinion in Solid State & Materials Science2009，，5： | 3 |
| 5 | Preliminary study of microstructure, mechanical properties and corrosion resistance of antibacterial Ti-15Zr-xCu alloy for dental application显示文摘Ti-15 Zr-xCu(3≤x≤7,wt.%) novel antibacterial and antibiofilm alloys with competitive mechanical properties,biological responses and corrosion resistance were designed and fabricated.Annealing heat treatment on Ti-15 Zr-7 Cu(TZC-7 A),after holding for 2 h at slightly above their beta transus temperature(BTT) ensured their tensile strength(UTS),yield strength(YS) and hardness(HRV) were improved by31.2%,20% and 12.3% respectively compared to the control without Cu,Ti-15 Zr(T-15 ZA).Although the3 wt.% Cu alloy displayed the highest elongation(26%),the TZC-7 A alloy also possessed a good ductility.Presence of evenly dispersed Ti2 Cu and Zr2 Cu Cu-rich intermetallic phases formed as interwoven and alternating lamellae within the α+β matrix as a result of Cu addition,as revealed by X-ray diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).These greatly contributed to their strengthening and bactericidal properties.Over 98% antibacterial effect against E.coli and S.aureus have been imparted,coupled with excellent biofilm inhibition.Potentiodynamic polarization curves showed that the TZC-7 A alloy possessed higher corrosion resistance than commercially pure titanium,cp-Ti;contact angle test revealed enhanced hydrophilicity;while confocal laser scanning microscopy(CLSM) and cell counting kit(CCK-8) assays also displayed drastically lowered bacterial adhesion rate with comparatively no cytotoxicity.Cell attachment on all alloys was similar but the best spread was obtained on TZC-7 A after 24 h.The developed alloy has good potential as an antibacterial implant material with combination of optimized properties. | Sharafadeen Kunle Kolawole Wang Hai Shuyuan Zhang Ziqing Sun Muhammad Ali Siddiqui Ihsan Ullah Wei Song Frank Witte Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，15： | 2 |
| 6 | Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study显示文摘The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity.This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks’Balanced Salt Solution(HBSS)with and without in situ cyclic compression(30 N/1 Hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation.Although in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was preserved.Structural changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(p<0.05)in the material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of corrosion.However,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs. | Roxane Bonithon Colin Lupton Marta Roldo Joseph Nicholas Dunlop Gordon William Blunn Frank Witte Gianluca Tozzi | 2023 | Bioactive Materials2023，，1： | 2 |
| 7 | Chronic alcoholism causes deleterious conditioning of innate immnnity显示文摘 | Frank J Witte K Schrodl W | 2004 | Alcohol Alcohol2004，9，35： | 1 |
| 8 | Chronic alcoholism causes deleterious conditioning of innate immunity显示文摘 | Frank J Witte K Schrodl W | 2004 | Alcohol Alcoholism2004，39，5： | 1 |
| 9 | Chronic alcoholism causes deleterious conditioning of innate immunity显示文摘 | Frank J Witte K Schrodl W | 2004 | Alcohol and Alcohol2004，39，5： | 1 |
| 10 | Degradable biomaterials based on magnesium cor- rosion 显示文摘 | Frank Witte Norbert Hort Carla Vogt Smadar Cohen Karl UMch Kainer Regine Willumeit and Frank Feyer- abend | 2008 | Current Opinion in Solid State and Materials Science2008，12，56： | 1 |
| 11 | Marked differences in the prevalence of chloroquine resistance between urban and rural communities in Burkina Faso显示文摘 | Peter E. Meissner Germain Mandi Frank P. Mockenhaupt Steffen Witte Boubacar Coulibaly Ulrich Mansmann Claudia Frey Heiko Merkle Juergen Burhenne Ingeborg Walter-Sack Olaf Müller | 2007 | Acta Tropica2007，，1： | 1 |
| 12 | Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection显示文摘 | Andreas Mas Marques Tobias Mueller Justus Welke Stefan Taube Christoph Sarrazin Manfred Wiese Juliane Halangk Heiko Witt Golo Ahlenstiel Ulrich Spengler Uwe Goebel Eckart Schott Viola Weich Beate Schlosser Hermann E. Wasmuth Frank Lammert Thomas Berg Ecka | 2009 | Infection, Genetics and Evolution2009，，5： | 1 |
| 13 | 显示文摘 | Frank Witte Jens Fischer Jens Nellesen | 2006 | Biomaterial2006，9，： | 1 |
| 14 | In vitro and in vivo corrosion measurements of magnesium alloys显示文摘 | Frank Witte Jens Fischer Jens Nellesen Horst-Artur Crostack Volker Kaese Alexander Pisch Felix Beckmann Henning Windhagen | 2005 | Biomaterials2005，，7： | 1 |
| 15 | Degradable bioma- terials based on magnesium corrosion 显示文摘 | Frank witte Nor bert Hort Carla Vogt | 2008 | Curt Opin Solid State Mater Sci2008，12，56： | 1 |
| 16 | Biodegradable magnesium-hydroxyapatite metal matrix composites 显示文摘 | Frank Witte Frank Feyerabend Petra Maier | 2007 | Biomaterials2007，28，： | 1 |
| 17 | Biodegradable magnesium-hydroxyapatite metal matrix composites 显示文摘 | Frank Witte Frank Feyerabend Petra Maier | 2007 | Biomaterials2007，28，： | 1 |
| 18 | The History of Biodegradable Magnesium Implants : A Review 显示文摘 | Frank Witte | 2010 | Acta Biomaterialia2010，，6： | 1 |
| 19 | L-arginine supplementation enhances diabetic wound healing:Involvement of the nitric oxide synthase and arginase pathways显示文摘 | Witte Maria B Thornton Frank J Tantry Udaya et a1 | 2002 | Metabolism:Clinical & Experimental2002，51，10： | 1 |
| 20 | Sleep Apnea Syndrome in Patients with Cardisc Pacemaker显示文摘 | SABINE QUISPE-BRAVO FRANK RIEDEL JOACHIM WITTE | 2000 | Reapiration2000，67，3： | 1 |
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