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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | 岩石破裂以及破裂前信号的演变显示文摘地震是大量的岩石破裂事件。很多大地震之前都存在瞬态信号:电磁信号、磁场变化、电离层扰动、土壤导电率的变化以及其他震前信号。令监测人员奇怪的是,在震前短时间内一些震前信号会衰弱甚至消失不见。岩石中应力活化电流的发现提供了一个可能的解释,应力能够激活岩石中的移动电荷载体,即电子空位缺陷(electron va-cancy defects,EVD),也称空穴,用h.表示。h.相当于O2-中的O-,且以电钝性及休止的状态存在于无应力岩石中。当被激活时,h.沿着应力梯度方向流动,从而产生电流。在非常高的应力速率下,位错累积成微破裂,这正是灾变破裂的开始。当h.电荷载体无法再被激活时,震前破裂信号会明显衰弱。 | Freund F T Dahlgren R P Chu J j 张祯(译) 田家勇(校) | 2011 | 国际地震动态2011，，1： | 4 |
| 3 | 菱面体畸变的钙钛矿结构多铁性氧化物薄膜畴界精细结构显示文摘畴是所有铁性材料的一个共同本质特性,畴及畴界的结构极大影响着材料性能。本文应用高分辨透射电子显微学和定量电子显微学,在原子尺度定量研究了钙钛矿菱面体结构多铁性薄膜BiFeO3的109°畴界的精细结构,包括畴界附近阳离子位移及局部铁电极化分布。结果表明:正是由于畴界附近原子发生微小位移,导致材料能带的变化,带隙减小,从而在绝缘BiFeO3中产生独特的导电性能。这不仅为研究铁电极化反转和磁电效应等科学问题提供关键的定量结构信息,同时也促进相关材料的设计和性能优化。 | 詹倩 于荣 CHU Y H MARTIN L W RAMESH R | 2010 | 电子显微学报2010，29，5： | 2 |
| 4 | Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation显示文摘 | Hoontrakoon R Chu HW Gardai SJ | 2002 | Am J Respir Cell Mol Biol2002，26，： | 2 |
| 5 | A comparison of two methods for determining the weights of belonging to fuzzy sets 显示文摘 | Chu A T W Kalaba R E Spingarn K | 1979 | Journal of Optimization Theory and Application1979，27，： | 2 |
| 6 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 7 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 8 | Prenatal screening for Down syndrome in England and Wales and population - based birth out - comes显示文摘 | Smith-Bindman R Chu P Baehetti P | 2003 | Am J Obetet Gymecol2003，189，4： | 1 |
| 9 | Comparing suprapu bic urine aspiration under real-time ultrasound guidance with conventional blind aspiration显示文摘 | Chu R W Wong Y C Luk S H Wong S N | 2002 | Acta Paediatr2002，91，： | 1 |
| 10 | Wind-induced vibration of high-rise building with tuned mass damper including soil-structure interaction显示文摘 | Liu M Y Chiang W L Hwang J H Chu C R | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 11 | Group decision - making using a fuzzy linguistic approach for evaluating the flexibility in a manufacturing system 显示文摘 | WANG R C CHU S J | 2004 | European Journal of Operational Research2004，，154： | 1 |
| 12 | Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolinms- and paelitaxel- eluting stents 显示文摘 | Kuchulakanti PK Chu WW Torguson R | 2006 | Circulation2006，113，8： | 1 |
| 13 | Antioxidant and antiproliferative activities of common vegetables显示文摘 | Chu Y F Sun J Wu X Liu R H | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 14 | Sustaining living rivers显示文摘 | Karr J R Chu E W | 2000 | Hydrobiologia2000，4，： | 1 |
| 15 | Turbulent gravity-stratified shear flows显示文摘 | CHU V T BADDOUR R E | 1984 | J Fluid Mech1984，138，： | 1 |
| 16 | Mechanism of hydroxyethyl starch on reducing pulmonary capillary permeability in a rat model of sepsis 显示文摘 | Lv R Zhou W Chu C | 2005 | Ann Clin Lab Sci2005，35，2： | 1 |
| 17 | Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus-and paclitaxel-eluting stents显示文摘 | KUCHULAKANTI P CHU W TORGUSON R | 2006 | Circulation2006，113，： | 1 |
| 18 | Human adenoviruses and coliphages in urban runoff-impacted coastal waters of Southern California显示文摘 | JIANG S NOBLE R CHU W | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 19 | Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-anal- ysis 显示文摘 | Chu S G Becker R C Berger P B | 2010 | J Thromb Haemost2010，8，1： | 1 |
| 20 | Expression, char- acterization,and tissue distribution of a new cellular selenium - dependent glutathione peroxidase, GSHPx - GI 显示文摘 | Chu F F Doroshow J Esworthy R | 1993 | Journal of Biological Chemistry1993，268，4： | 1 |
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