|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility显示文摘由他们表示的水平的比较 proteomics 和确认与精索静脉曲张在不肥沃的人在精子蛋白质的分发学习主要差别。为每精索静脉曲张结果的学习特定的估计被联合识别不管他们的临床的精索静脉曲张的舞台和对一个侧面的偏重,在人涉及联系精索静脉曲张的不孕的蛋白质。5 关键蛋白质(PKAR1A, AK7, CCT6B, HSPA2,和 ODF2 ) 的表达式层次在压力反应包含了,包括分子的女伴的精子功能被西方的弄污验证。99 蛋白质是在精索静脉曲张组表示的差别。涉及主要精力新陈代谢和关键精子功能的超过 87% DEP 是在精索静脉曲张组的 underexpressed。在精索静脉曲张组影响的关键蛋白质功能是精子发生,精子活动性,和 mitochondrial 机能障碍,它被西方的弄污进一步验证,支持 proteomics 分析。精索静脉曲张是实质上由于损害的血供应的精力剥夺,组织缺氧,和过高热的一个状态,它被类脂化合物新陈代谢, mitochondrial 电子运输链,和克雷布斯周期的下面规定支持酶。支持 proteomic 分析,兴趣的 5 识别蛋白质的表示被西方的弄污验证。这研究向建立 biomarker “ 作出贡献; fingerprint”根据分子的参数估计精子质量。 | Ashok Agarwal Rakesh Sharma Luna Samanta Damayanthi Durairajanayagam Edmund Sabanegh | 2016 | Asian Journal of Andrology2016，18，2： | 6 |
| 2 | Dengue and its effects on liver显示文摘Dengue has emerged as an important arboviral disease with significant impact on the disease burden in population residing in tropical countries. Dengue is spread by the bite of Aedes mosquito. The virus seems to have some hepatotoxic effects. Affliction of liver in form of derangements in the liver function tests is common and may include mild elevations in serum bilirubin, elevated transaminases and derangements in serum albumin. Although asymptomatic in most cases, clinical manifestations like jaundice, and acute liver failure(ALF) may occasionally complicate the clinical picture. Indeed, dengue has been implicated as an important cause of ALF in endemic countries. The present review focuses on the hepatic manifestations and the pathogenesis of the liver injury in dengue. | Jayanta Samanta Vishal Sharma | 2015 | World Journal of Clinical Cases2015，3，2： | 4 |
| 3 | Analysis of a hand-foot-mouth disease model显示文摘 | Swarnali Sharma G. P. Samanta | 2017 | International Journal of Biomathematics2017，10，2： | 2 |
| 4 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 5 | Regulation of IMP3 by EGFR signaling and repression by ER:implication for triple negative breast cancer显示文摘 | Samanta S Sharma VM Khan | 2010 | Oncogene2010，25，1： | 1 |
| 6 | Regulation of IMP3 by EG- FR signaling and repression by ERbeta: implications for triple- negative breast cancer显示文摘 | Samanta S Sharma VM Khan A | 2012 | Oncogene2012，31，44： | 1 |
| 7 | Stability analysis and optimal control of an epidemic model with vaccination显示文摘 | Swarnali Sharma G. P. Samanta | 2015 | International Journal of Biomathematics2015，8，3： | 1 |
| 8 | Dynamical behaviour of a two preys and one predator system显示文摘 | Sharma S Samanta G P | 2014 | Differ Equ Dyn Syst2014，22，2： | 1 |
| 9 | Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis显示文摘BACKGROUND Early prediction of response to percutaneous catheter drainage(PCD)of necrotic collections in acute pancreatitis(AP)using simple and objective tests is critical as it may determine patient prognosis.The role of white blood cell(WBC)count and neutrophil-lymphocyte ratio(NLR)has not been assessed as a tool of early prediction of PCD success and is the focus of this study.AIM To assess the value of WBC and NLR in predicting response to PCD in AP.METHODS This retrospective study comprised consecutive patients with AP who underwent PCD between June 2018 and December 2019.Severity and fluid collections were classified according to the revised Atlanta classification and organ failure was defined according to the modified Marshall Score.WBC and NLR were monitored 24 h prior PCD(WBC-0/NLR-0)and 24 h(WBC-1/NLR-1),48 h(WBC-2/NLR-2)and 72 h(WBC-3/NLR-3)after PCD.NLR was calculated by dividing the number of neutrophils by the number of lymphocytes.The association of success of PCD(defined as survival without the need for surgery)with WBC and NLR was assessed.The trend of WBC and NLR was also assessed post PCD.RESULTS One hundred fifty-five patients[median age 40±13.6(SD),64.5%males,53.5%severe AP]were included in the final analysis.PCD was done for acute necrotic collection in 99(63.8%)patients and walled-off necrosis in 56(36.1%)patients.Median pain to PCD interval was 24±69.89 d.PCD was successful in 109 patients(group 1)and 46 patients(group 2)who failed to respond.There was no significant difference in the baseline characteristics between the two groups except the severity of AP and frequency of organ failure.Both WBC and NLR showed an overall decreasing trend.There was a significant difference between WBC-0 and WBC-1(P=0.0001).WBC-1 and NLR-1 were significantly different between the two groups(P=0.048 and 0.003,respectively).The area under the curve of WBC-1 and NLR-1 for predicting the success of PCD was 0.602 and 0.682,respectively.At a cut-off value of 9.87 for NLR-1,the sensitivity and specificity for predicting the success of PCD were calculated to be 75%and 65.4%respectively.CONCLUSION WBC and NLR can be used as simple tests for predicting response to PCD in patients with acute necrotizing pancreatitis. | Pankaj Gupta Gaurav Chayan Das Akash Bansal Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Shano Naseem Vikas Gupta Thakur Deen Yadav Usha Dutta Neelam Varma Manavjit Singh Sandhu Rakesh Kochhar | 2022 | World Journal of Clinical Cases2022，10，1： | 1 |
| 10 | Arsenic and other elements in hair, nails, and skin-scales of arsenic victims in West Bengal, India显示文摘 | Samanta G Sharma R Roychowdhury T | 2004 | Sci Total Environ2004，326，13： | 1 |
| 11 | Influence of pH on Structural and Electrical Properties of Sol-gel Derived ( Ba, Sr) TiO3 Thin Films under Humid Conditions显示文摘 | Agarwal S Samanta S B Sharma G L | 2004 | Thin Solid Films2004，，： | 1 |
| 12 | Arsenic and Other Elements in Hair, Nails, and Skin-Sscales of Arsenic Victims in West Bengal,India显示文摘 | Samanta G Sharma R Roychowdhury T | 2004 | Sci Total Environ2004，326，： | 1 |
| 13 | Arsenic and other elements in hair, nails, and skin-scales of arsenic victims in West Bengal, India 显示文摘 | Samanta G Sharma R Roychowdhury T | 2004 | Sci Total Environ2004，326，： | 1 |
| 14 | Effect of awareness programs by media on the epidemic out- breaks: A mathematical model显示文摘 | SAMANTA S RANA S SHARMA A | 2013 | Applied Mathematics and Computation2013，219，12： | 1 |
| 15 | Regulation of IMP3 by EGFR signaling and repression by ERI3: implications for triple-negative breast cancer显示文摘 | Samanta S Sharma VM Khan A | 2012 | Oncogene2012，80，31： | 1 |
| 16 | Regulation of IMP3 by EGFR signaling and repression by ERbeta : implications for triple- negative breast cancer 显示文摘 | Samanta S Sharma VM Khan A | 2012 | Oncogene2012，31，44： | 1 |
| 17 | Arsenic and other elements in hair,nails,and skin-scales of arsenic victims in West Bengal,India显示文摘 | Samanta G Sharma R Roychowdhury T | 2004 | Science of the Total Environment2004，326，： | 1 |
| 18 | Regulation of IMP3by EGFR signaling and repression by ERbeta : implicationsfor triple-negative breast cancer 显示文摘 | Samanta S Sharma VM Khan A | 2012 | Oncogene2012，44，46： | 1 |
| 19 | Regulation of IMP3 by EGFR signaling and repression by ER:implication for triple negative breast cancer显示文摘 | Samanta S Sharma V M | 2010 | Oncogene2010，25，1： | 1 |
| 20 | A Leslie-Gower preda- tor-prey model with disease in prey incorporating a prey refuge显示文摘 | SHARMA S SAMANTA G P | 2015 | Chaos Solitons & Fractals2015，70，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员