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| 1 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 2 | Temperature sensitivity of organic compound destruction in SCWO process显示文摘To study the temperature sensitivity of the destruction of organic compounds in supercritical water oxidation process(SCWO), oxidation effects of twelve chemicals in supercritical water were investigated. The SCWO reaction rates of different compounds improved to varying degrees with the increase of temperature, so the highest slope of the temperature-effect curve(imax) was defined as the maximum ratio of removal ratio to working temperature. It is an important index to stand for the temperature sensitivity effect in SCWO. It was proven that the higher imax is, the more significant the effect of temperature on the SCWO effect is. Since the high-temperature area of SCWO equipment is subject to considerable damage from fatigue, the temperature is of great significance in SCWO equipment operation. Generally, most compounds(imax > 0.25) can be completely oxidized when the reactor temperature reaches 500℃. However, some compounds(imax > 0.25) need a higher temperature for complete oxidation, up to 560℃. To analyze the correlation coefficients between imax and various molecular descriptors, a quantum chemical method was used in this study. The structures of the twelve organic compounds were optimized by the Density Functional Theory B3LYP/6-311G method, as well as their quantum properties. It was shown that six molecular descriptors were negatively correlated to imax while other three descriptors were positively correlated to imax. Among them, dipole moment had the greatest effect on the oxidation thermodynamics of the twelve organic compounds. Once a correlation between molecular descriptors and imax is established, SCWO can be run at an appropriate temperature according to molecular structure. | Yaqin Tan Zhemin Shen Weimin Guo Chuang Ouyang Jinping Jia Weili Jiang Haiyun Zhou | 2014 | Journal of Environmental Sciences2014，26，3： | 2 |
| 3 | Effects of SRT and DO on nutrient removal in a combined AS-biofilm process 显示文摘 | Chuang S H Ouyang C F Yuang H C | 1997 | Water Sci Technol1997，36，： | 1 |
| 4 | Optimal inventory policies involving variable lead time with defective items显示文摘 | OUYANG L Y CHUANG B R WU K S | 1999 | Journal of the Operational Research Society of India1999，36，： | 1 |
| 5 | The biomass fractions of heterotrophs and phosphate-accmnalating organisms in a nitrogen and phosphorus removal system显示文摘 | Chuang S H Ouyang C F | 2000 | Wat Res2000，34，8： | 1 |
| 6 | A note on periods review model with controllable setup cost and lead time 显示文摘 | Chuang B R Ouyang L Y Chuang K W | 2004 | Computers and Operations Research2004，31，4： | 1 |
| 7 | Versatile sensing devices for self-driven designated therapy based on robust breathable composite films显示文摘Flexible wearable electronics were developed for applications such as electronic skins,human-machine interactions,healthcare monitoring,and anti-infection therapy.But conventional materials showed impermeability,single sensing ability,and no designated therapy,which hindered their applications.Thus it was still a great challenge to develop electronic devices with multifunctional sensing properties and self-driven anti-infection therapy.Herein,flexible and breathable on-skin electronic devices for multifunctional fabric based sensing and self-driven designated anti-infection therapy were prepared successfully with cellulose nanocrystals/iron(Ⅲ)ion/polyvinyl alcohol(CNC/Fe^(3+)/PVA)composite.The resultant composite films possessed robust mechanical performances,outstanding conductivity,and distinguished breathability(3.03 kg/(m^(2)·d)),which benefited from the multiple interactions of weak hydrogen bonds and Fe^(3+) chelation and synergistic effects among CNC,polyaniline(PANI),and PVA.Surprisingly,the film could be assembled as a multifunctional sensor to actively monitor real-time physical and infection related signals such as temperature,moisture,pH,NH3,and human movements even at sweat states.More importantly,this multifunctional device could act as a self-driven therapist to eliminate bacterial by the release of Fe^(3+),which was driven by the damage of metal coordination Fe-O bonds due to the high temperature caused by infection at wound sites.Thus,the composite films had potential versatile applications in electronic skins,smart wound dressings,human-machine interactions,and self-driven anti-infection therapy. | Zhaofeng Ouyang Songbo Cui Houyong Yu Dewen Xu Chuang Wang Dongping Tang Kam Chiu Tam | 2022 | Nano Research2022，15，2： | 1 |
| 8 | Nitrification efficiency and nitrifying bacteria abundance in combined AS-RBC and AzO systems 显示文摘 | You S J Chuang S H Ouyang C F | 2003 | Water Research2003，37，10： | 1 |
| 9 | The biomass fraction of heterotrophic and phosphate-accumulating organisms in a nitrogen and phosphorus removal system显示文摘 | Chuang S H Ouyang C T | 2000 | Water Research2000，34，8： | 1 |
| 10 | Stochastic Inventory Model Involving Variable Lead Time with a Service Level显示文摘 | Ouyang L Y Chuang B R | 2006 | Yugoslav Journal of Operations Research2006，10，1： | 1 |
| 11 | The biomass fraction of the heterotrophs and phosphate-accumulating organisms in a nitrogen and phosphorus removal system显示文摘 | Chuang S H Ouyang C F | 2000 | War Res2000，34，8： | 1 |
| 12 | Economic order quantity model under cash discounted payment delay显示文摘 | Ouyang L Y Chen M S Chuang K W | 2002 | International Journal of Information and Management Sciences2002，13，1： | 1 |
| 13 | Economic order quantity with partial backorders under supplier credit显示文摘 | Ouyang L Y Wu C C Chuang K W | 2003 | Journal of Information & Optimization Sciences2003，24，： | 1 |
| 14 | Kineticcompetition between phosphorus release anddenitrification on sludge under anoxic condition 显示文摘 | CHUANG S H OUYANG C F WANG Y B | 1996 | Water Research1996，30，12： | 1 |
| 15 | Economic order quantity model under cash discount and payment delay 显示文摘 | Ouyang L Y Chen M S Chuang K W | 2002 | International Jouranl of Information and Management Sciences2002，13，： | 1 |
| 16 | Mixture inventory model involving variable lead time and controllable backorder rate显示文摘 | OUYANG Ling - yah Chuang Bor - ten | 2001 | Computer &Industrial Engineering2001，40，： | 1 |
| 17 | A minimax distribution free procedure for periodic review inventory model involving variable lead time显示文摘 | Ouyang L Y Chuang B R | 1998 | International Journal of Information and Management Sciences1998，9，： | 1 |
| 18 | Stochastic inventory model involving variable lead time with a service level显示文摘 | Ouyang L Y Chuang B R | 2000 | Yugoslav Journal of Operations Research2000，10，1： | 1 |
| 19 | Kinetic competition between phosphorus release and denitrification sludge under anoxic condition显示文摘 | Chuang S H Ouyang C F Wang B | 1996 | Wat Res1996，30，12： | 1 |
| 20 | The biomass fraction of heterotrophs and phosphate-accumulating organism in a nitrogen and phosphorus removal system显示文摘 | Chuang S H Ouyang C F | 2000 | Wat Res2000，34，8： | 1 |
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