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| 1 | Role of gastrin-peptides in Barrett's and colorectal carcinogenesis显示文摘Gastrin is the main hormone responsible for the stimulation of gastric acid secretion;in addition,gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types.Gastrin synthesis and secretion are increased in certain situations,for example,when proton pump inhibitors are used.The impact of sustained hypergastrinemia is currently being investigated.In vitro experiments and animal models have shown that prolonged hypergastrinemia may be related with higher cancer rates;although,this relationship is less clear in human beings.Higher gastrin levels have been shown to cause hyperplasia of several cell types;yet,the risk for developing cancer seems to be the same in normo-and hypergastrinemic patients.Some tumors also produce their own gastrin,which can act in an autocrine manner promoting tumor growth.Certain cancers are extremely dependent on gastrin to proliferate.Initial research focused only on the effects of amidated gastrins,but there has been an interest in intermediates of gastrin in the last few decades.These intermediates aren't biologically inactive;in fact,they may exert greater effects on proliferation and apoptosis than the completely processed forms.In certain gastrin overproduction states,they are the most abundant gastrin peptides secreted.The purpose of this review is to examine the gastrin biosynthesis process and to summarize the results from different studies evaluating the production,levels,and effects of the main forms of gastrin in different overexpression states and their possible relationship with Barrett's and colorectal carcinogenesis. | Eduardo Chueca Angel Lanas Elena Piazuelo | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 2 | Modulation of faecal metagenome in Crohn's disease:Role of microRNAs as biomarkers显示文摘BACKGROUND The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16 S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease(IBD) is abnormal and characterized by reduced diversity. Micro RNAs(miRNAs) have been explored as biomarkers and therapeutic targets, since they are able to regulate specific genes associated with Crohn's disease(CD). In this work, we aim to investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.AIM To investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.METHODS Patients attending the outpatient clinics at Valme University Hospital without relevant co-morbidities were matched according to age and gender. Faecal samples of newonset CD patients, free of treatment, and healthy controls were collected. Faecal samples were homogenized, and DNA was amplified by PCR using primers directed to the 16 S bacterial rRNA gene. Pyrosequencing was performed using GS-Junior platform. For sequence analysis, MGRAST server with the database Ribosomal Project was used. MiRNA profile and their relative abundance were analyzed by quantitative PCR.RESULTS Microbial community was characterized using 16 S rRNA gene sequencing in 29 samples(n = 13 CD patients, and n = 16 healthy controls). The mean Shannon diversity was higher in the healthy control population compared to CD group(5.5 vs 3.7). A reduction in Firmicutes and an increase in Bacteroidetes were found. Clostridia class was also significantly reduced in CD. Principal components analysis showed a grouping pattern, identified in most of the subjects in both groups, showing a marked difference between control and CD groups. A functional metabolic study showed that a lower metabolism of carbohydrates(P = 0.000) was found in CD group, while the metabolism of lipids was increased. In CD patients, three miRNAs were induced in affected mucosa: mir-144(6.2 ± 1.3 fold), mir-519(21.8 ± 3.1) and mir-211(2.3 ± 0.4). CONCLUSION Changes in microbial function in active non-treated CD subjects and three miRNAs in affected vs non-affected mucosa have been found. miRNAs profile may serve as a biomarker. | María Rojas-Feria Teresa Romero-García Jose Angel Fernández Caballero-Rico Helena Pastor Ramírez Marta Avilés-Recio Manuel Castro-Fernandez Natalia Chueca Porcuna Manuel Romero-Gomez Federico García Lourdes Grande JoséA Del Campo | 2018 | World Journal of Gastroenterology2018，24，46： | 7 |
| 3 | Permafrost distribution from BTS meas urements (Sierra de Telera, Central Pyrenees, Spain) : asses sing the importance of solar radiation in a mid elevation sha ded mountainous area显示文摘 | Julian A Chueca J | 2007 | Permafrost and Periglacial Proces ses2007，18，2： | 1 |
| 4 | Development of a sensor-controlled sprayer for applying low-volume bait treatments显示文摘 | Chueca P Garcera C Molto E Gutierrez A | 2008 | Crop Protection2008，27，10： | 1 |
| 5 | Risk assessment of pesticide spray drifl from citrus applications with air-blast sprayers in Spain显示文摘 | Cunha J P Chueca P Garcerd C | 2012 | Crop Protection2012，42，： | 1 |
| 6 | Permafrost distribution from BTS measurements (Sierra de Telera, Central Pyrenees, Spain) : assessing the importance of solar radiation in a mid-elevation shaded mountainous area 显示文摘 | JULIAN A CHUECA J | 2007 | Permafrost and Periglacial Processes2007，18，2： | 1 |
| 7 | Increased sucrose level and altered nitrogen metabolism in Arabidopsis thaliana transgenic plants expressing antisense chloroplastic fructose-l,6-bisphosphatase显示文摘 | Sahrawy M Concepcidn Avila Ana Chueca | 2004 | Journal of Experimental Botany2004，55，408： | 1 |
| 8 | Responses to climatic changes since the little ice age on Maladeta glacier(central Pyrenees)显示文摘 | CHUECA C J ANDRES A J SAZ SANCHEZ M A | 2005 | Geomorphology2005，68，34： | 1 |
| 9 | Electrocardiographic Recognition of the Epicardial Origin of Ventricular Tachycardias显示文摘 | Antonio Berruezo Lluis Mont Santiago Nava Enrique Chueca Eduardo Bartholomay Josep Brugada | 2004 | Circulation: Journal of the American Heart Association2004，，15： | 1 |
| 10 | Improvement in the de- termination of HIV-1 tropism using the V3 gene sequence and a combination of bioinformatic tools显示文摘 | Chueca N Garrido C Alvarez M | 2009 | J Med Virol2009，81，5： | 1 |
| 11 | Expression of thioredoxins f and m, and of their targets fructose-1, 6- bisphosphatase and NADP-malate dehydrogenase, in pea plants grown under normal and light/temperature stress conditions 显示文摘 | PAGANO E A CHUECA A LOPEZ-GORGE J | 2000 | Journal of Experimental Botany2000，51，348： | 1 |
| 12 | Evaluation of eightdiffer- entbioinformaticstools to predictviraltropism in differenthuman- immunodeficiencyvirustypelsubtypes 显示文摘 | Garrido C Roulet V Chueca N | 2008 | J Clin Mierobiol2008，46，3： | 1 |
| 13 | Development of a sensor-controlled sprayer for applying low-volume bait treatments显示文摘 | Chueca P Garcera C Molto E | 2008 | Crop Protection2008，27，10： | 1 |
| 14 | Improving Clinical Labora- tory Efficiency;Introduction of Systems for the Diagnosis and Mo- nitoring of HIV Infection显示文摘 | Alvarez M Chueca N Guillot V | 2012 | Open Virol J2012，6，： | 1 |
| 15 | Chloroplast fructose-1,6-bisphosphatase: structure and function 显示文摘 | Chueca A Sahrawy M Pagano E A | 2002 | Photosynthe- sis Research2002，74，3： | 1 |
| 16 | Actualización en la terapia de la hepatitis C. Nuevos fármacos, monitorización de la respuesta y resistencias显示文摘 | Natalia Chueca Porcuna Marta álvarez Estévez Jorge Parra Ruiz José Hernández Quero Federico García García | 2013 | Enfermedades Infecciosas y Microbiologia Clinica2013，，： | 1 |
| 17 | The component combined amino acids of some marine phytoplankton species 显示文摘 | Chau Y K Chuecas L Riley J P | 1967 | Journal of the Marine Biological Association of the United Kingdom1967，47，3： | 1 |
| 18 | Input parameters of the HV model above canarian observatories 显示文摘 | Sergio Chueca Begona Garcia-Lorenzo | 1994 | SPIE1994，2201，： | 1 |
| 19 | Changing sugar partitioning in FBPase-manipulated plants 显示文摘 | Serrato A J Barajas-L6pez J D Chueca A | 2009 | Journal of Experimental Botany2009，60，10： | 1 |
| 20 | Component fatty acids of the total lipids of some marine phytoplankton显示文摘 | Chuecas L Riley J P | | 0，，： | 1 |
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