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| 1 | Mechanisms of triglyceride metabolism in patients with bile acid diarrhea显示文摘Bile acids(BAs) are essential for the absorption of lipids. BA synthesis is inhibited through intestinal farnesoid X receptor(FXR) activity. BA sequestration is known to influence BA metabolism and control serum lipid concentrations. Animal data has demonstrated a regulatory role for the FXR in triglyceride metabolism. FXR inhibits hepatic lipogenesis by inhibiting the expression of sterol regulatory element binding protein 1c via small heterodimer primer activity. Conversely, FXR promotes free fatty acids oxidation by inducing the expression of peroxisome proliferator-activated receptor α. FXR can reduce the expression of microsomal triglyceride transfer protein, which regulates the assembly of very low-density lipoproteins(VLDL). FXR activation in turn promotes the clearance of circulating triglycerides by inducing apolipoprotein C-Ⅱ, very low-density lipoproteins receptor(VLDL-R) and the expression of Syndecan-1 together with the repression of apolipoprotein C-Ⅲ, which increases lipoprotein lipase activity. There is currently minimal clinical data on triglyceride metabolism in patients with bile acid diarrhoea(BAD). Emerging data suggests that a third of patients with BAD have hypertriglyceridemia. Further research is required to establish the risk of hypertriglyceridaemia in patients with BAD and elicit the mechanisms behind this, allowing for targeted treatment. | Nidhi Midhu Sagar Michael McFarlane Chuka Nwokolo Karna Dev Bardhan Ramesh Pulendran Arasaradnam | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 2 | Short term results of pterygium surgery with adjunctive amniotic membrane graft显示文摘 | O Okoye N Oguego C Chuka Okosa M Ghanta | 2013 | Nigerian Journal of Clinical Practice2013，，3： | 2 |
| 3 | Short term results of pterygium surgery with adjunctive amniotic membrane graft显示文摘 | O Okoye N Oguego C Chuka Okosa M Ghanta | 2013 | Nigerian Journal of Clinical Practice2013，，3： | 1 |
| 4 | Barrett?s surveillance is worthwhile and detects curable cancers. A prospective cohort study addressing cancer incidence, treatment outcome and survival显示文摘 | David M. Aldulaimi Mark Cox Chuka U. Nwokolo Duncan E. Loft | 2005 | European Journal of Gastroenterology & Hepatology2005，，： | 1 |
| 5 | Paracentesis as surgical intervention intraumatic Hyphema: opinions and practices of Nigerian ophthalmol-ogists 显示文摘 | Chuka OM Obizoba OL | 2012 | Ophthalmol Eye Dis2012，4，： | 1 |
| 6 | Dynamics of Globalization: Linguistic and Cultural Perspectives in Nigeria显示文摘 | Chuka Chukwube | 2015 | Journal of Literature and Art Studies2015，5，1： | 0 |
| 7 | WIDE:A witness-based data priority mechanism for vehicular forensics显示文摘In this paper,we present a WItness based Data priority mEchanism(WIDE)for vehicles in the vicinity of an accident to facilitate liability decisions.WIDE evaluates the integrity of data generated by these vehicles,called witnesses,in the event of an accident to assure the reliability of data to be used for making liability decisions and ensure that such data are received from credible witnesses.To achieve this,WIDE introduces a two-level integrity assessment to achieve end-to-end integrity by initially ascertaining the integrity of data-producing sensors,and validating that data generated have not been altered on transit by compromised road-side units(RSUs)by executing a practical byzantine fault tolerance(pBFT)protocol to reach consensus on data reliability.Furthermore,WIDE utilises a blockchain based reputation management system(BRMS)to ensure that only data from highly reputable witnesses are utilised as contributing evidence for facilitating liability decisions.Finally,we formally verify the proposed framework against data integrity requirements using the Automated Verification of Internet Security Protocols and Applications(AVISPA)with High-Level Protocol Specification Language(HLPSL).Qualitative arguments show that our proposed framework is secured against identified security attacks and assures the reliability of data utilised for making liability decisions,while quantitative evaluations demonstrate that our proposal is practical for fully autonomous vehicle forensics. | Chuka Ohama Regio A.Michelin Raja Jurdak Salil S.Kanhere Sanjay Jha | 2022 | Blockchain(Research and Applications)2022，3，2： | 0 |
| 8 | The Effect of Bridging Liquid Surface Tension and Specific Surface Area on Strength Factor of Coal Agglomerates显示文摘 | Kingsley Okechukwu Ikebudu Emmanuel Chuka Chinwuko Emmanuel Okechukwu Chukwumuanya | 2012 | Journal of Mechanics Engineering and Automation2012，2，2： | 0 |
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