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| 1 | Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells显示文摘目的: 间充质的干细胞(MSC ) 是心脏的代替治疗的一个有希望的候选人。然而,因为差的血供给, ischemia-reperfusion,和煽动性的因素,移植 MSC 的多数乐意地在移植以后被失去。我们试图在 MSC.Methods 的 hypoxia/reoxygenation-induced apoptosis 上学习组织缺氧 preconditioning ( HPC )的效果: MSC 的三代被划分成 6 个组包括正常的组, hypoxia-reoxygenation ( H/R )组, cyclosporine A ( CsA ),和 HPC 10 min , 20 min ,并且 30 min 组织。 apoptotic 索引,房间生存能力, mitochondrial 膜电位, Bcl-2 和 bax 的易位,细胞外的调整激酶(英皇家空军之阶级最低之兵), Akt ,组织缺氧可诱导的因素 1-alpha ,并且脉管的内皮生长因素( VEGF )在 H/R treatment.Results 以后被测试: HPC 减少了 apoptotic 索引并且增加了 H/R.Moreover 导致的生存能力, HPC 显著地稳定了 mitochondrial 膜电位在调整 Bcl-2 和 VEGF 表达式上面,并且增加了英皇家空军之阶级最低之兵和 Akt.As 的磷酸化积极控制, CsA 有象 HPC 的一样的函数,除了支持英皇家空军之阶级最低之兵和 Akt 磷酸化并且在调整 VEGF.Conclusion 上面: HPC 对 H/R 经由稳定 mitochondrial 膜电位导致的 MSC apoptosis 有保护的效果在调整 Bcl-2 和 VEGF 上面,并且支持英皇家空军之阶级最低之兵和 Akt phosphorylation.HPC 为新奇干细胞protective 策略的开发有含意。 | Jian-an WANG Tie-long CHEN Jun JIANG Heng SHI Chun GUI Rong-hua LUO Xiao-jie XIE Mei-xiang XIANG Xing ZHANG | 2008 | Acta Pharmacologica Sinica2008，29，1： | 25 |
| 2 | Effects of Percutaneous Coronary Intervention on Serum Angiopoietin-2 in Patients with Coronary Heart Disease显示文摘 | Zhi-Yu Zeng Chun Gui Lang Li Xiao-Min Wei | 2016 | Chinese Medical Journal2016，，6： | 22 |
| 3 | Optimal time for mesenchymal stem cell transplantation in rats with myocardial infarction显示文摘Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of this study was to find an optimal time point for cell transplantation. Methods: MSCs were isolated and cultured from Sprague-Dawley (SD) rats. MI model was set up in SD rats by permanent ligation of left anterior descending coronary artery. MSCs were directly injected into the infarct border zone at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume of phosphate buffered saline (PBS). At 4 weeks after MI, cardiac function was assessed by echocardiography; vessel density was analyzed on hematoxylin-eosin stained slides by light microscopy; the apoptosis of cardiomyocytes was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expressions of proteins were analyzed by Western blot. Results: MSC transplantation improved cardiac function, reduced the apoptosis of cardiomyocytes and increased vessel density. These benefits were more obvious in 1-week group than in 1-h and 2-week groups. There are more obvious in-creases in the ratio of bcl-2/bax and the expression of vascular endothelial growth factor (VEGF) and more obvious decreases in the expression of cleaved-caspase-3 in 1-week group than those in other two groups. Conclusion: MSC transplantation was beneficial for the recovery of cardiac function. MSC transplantation at 1 week post-MI exerted the best effects on increases of cardiac function, anti-apoptosis and angiogenesis. | Chen-yang JIANG Chun GUI Ai-na HE Xin-yang HU Jie CHEN Yun JIANG Jian-an WANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，8： | 18 |
| 4 | Angiopoietin-1 protects mesenchymal stem cells against serum depriva-tion and hypoxia-induced apoptosis through the PI3K/Akt pathway显示文摘瞄准:表明系统的 angiopoietin-1 (Angl )/Tie-2 不仅在容器生长起一个枢轴的作用,改变,并且 endothelial,神经原,和 cardiomyocytes 的成熟,而且还原剂 apoptosis。然而,相对,很少至于 Angl 是否在间充质的干细胞(MSC ) 上有保护的效果被知道。现在的学习的目的是调查对浆液剥夺和导致组织缺氧的 apoptosis 在 MSC 上发信号的 Angl/Tie-2 的保护的效果,并且决定可能的机制。方法:Hoechst 33342 和终端 deoxynucleotidyl 标记染色的调停 transferase 的 digoxigenin-dUTP 刻痕结束被用来估计 MSC 的 apoptosis。Tie-2, Akt, Bcl-2, Bax,和劈开的 caspase-9 和 -3 的表示被西方的污点分析检测。结果:这研究证明 MSC 表示了 Tie-2 受体,并且 Angl 导致了 Tie-2 受体磷酸化。MSC 上的 Angl 的保护的效果是剂量依赖者并且在 50 ug/L 达到顶点;然而,可溶的 Tie-2/Fc 熔化蛋白质,它由扣押充当一个禁止者 Angl,废除了 anti-apoptotic 效果。Angl 导致了 Akt 磷酸化,增加了 Bcl-2/Bax 比率,并且减少 caspase-9 和 -3 的激活。所有这些效果被 Tie-2/Fc 和 phosphatidylinositol 稀释 3 激酶(PI3K ) 禁止者, wortmannin。结论:这些结果证明 Angl 能保护 MSC 免于浆液剥夺和导致组织缺氧的 apoptosis;Angl/Tie-2 发信号和它的下游的 PI3K/Akt 送信人小径在导致 MSC 幸存的过程是关键的。 | Xian-bao LIU Jun JIANG Chun GUI Xin-yang HU Mei-xiang XIANG Jian-an WANG | 2008 | Acta Pharmacologica Sinica2008，29，7： | 18 |
| 5 | Carbon carry capacity and carbon sequestration potential in China based on an integrated analysis of mature forest biomass显示文摘Forests play an important role in acting as a carbon sink of terrestrial ecosystem.Although global forests have huge carbon carrying capacity(CCC)and carbon sequestration potential(CSP),there were few quantification reports on Chinese forests.We collected and compiled a forest biomass dataset of China,a total of 5841 sites,based on forest inventory and literature search results.From the dataset we extracted 338 sites with forests aged over 80 years,a threshold for defining mature forest,to establish the mature forest biomass dataset.After analyzing the spatial pattern of the carbon density of Chinese mature forests and its controlling factors,we used carbon density of mature forests as the reference level,and conservatively estimated the CCC of the forests in China by interpolation methods of Regression Kriging,Inverse Distance Weighted and Partial Thin Plate Smoothing Spline.Combining with the sixth National Forest Resources Inventory,we also estimated the forest CSP.The results revealed positive relationships between carbon density of mature forests and temperature,precipitation and stand age,and the horizontal and elevational patterns of carbon density of mature forests can be well predicted by temperature and precipitation.The total CCC and CSP of the existing forests are 19.87 and 13.86 Pg C,respectively.Subtropical forests would have more CCC and CSP than other biomes.Consequently,relying on forests to uptake carbon by decreasing disturbance on forests would be an alternative approach for mitigating greenhouse gas concentration effects besides afforestation and reforestation. | LIU Ying Chun YU Gui Rui WANG Qiu Feng ZHANG Yang Jian XU Ze Hong | 2014 | Science China(Life Sciences)2014，57，12： | 15 |
| 6 | Detrimental Effect of Electromagnetic Pulse Exposure on Permeability of In Vitro Blood-brain-barrier Model显示文摘Objective To study the effect of electromagnetic pulse (EMP) exposure on permeability of in vitro blood-brain-barrier (BBB) model. Methods An in vitro BBB model, established by co-culturing brain microvascular endothelial cells (BMVEC) and astroglial cells (AC) isolated from rat brain, was exposed to EMP at 100 kV/m and 400 kV/m, respectively. Permeability of the model was assayed by measuring the transendothelial electrical resistance (TEER) and the horseradish peroxidase (HRP) transmission at different time points. Levels of BBB tight junction-related proteins were measured at 0, 1, 2, 4, 8, 12, 16, 20, 24 h after EMP exposure by Western blotting. Results The TEER level was lower in BBB model group than in control group at 12 h after EMP, exposure which returned to its normal level at 24 h. The 24 h recovery process was triphasic and biphasic respectively after EMP exposure at 100 kV/m and 400 kV/m. Following exposure to 400 kV/m EMP, the HRP permeability increased at 1-12 h and returned to its normal level at 24 h. Western blotting showed that the claudin-5 and ZO-1 protein levels were changed after EMP exposure. Conclusion EMP exposure at 100 kV/m and 400 kV/m can increase the permeability of in vitro BBB model and BBB tight junction-related proteins such as ZO-1 and claudin-5 may change EMP-induced BBB permeability. | ZHOU Jia Xing DING Gui Rong ZHANG Jie ZHOU Yong Chun ZHANG Yan Jun GUO Guo Zhen | 2013 | Biomedical and Environmental Sciences2013，26，2： | 10 |
| 7 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 8 | Protective paracrine effect of mesenchymal stem cells on cardiomyocytes显示文摘Objective:The aim of this study was to test the protective effect of mesenchymal stem cells(MSCs) on cardiomyocytes in vitro and to investigate the anti-apoptotic signaling pathway.Methods:MSCs from Sprague-Dawley(SD) rats were separated and cultured.MSC medium was collected from MSCs cultured in serum-free Dulbecco's modified eagle medium(DMEM) under hypoxia.Cultured cardiomyocytes from neonatal SD rats were exposed to hypoxia/reoxygenation(H/R) and treated with MSC medium.The apoptotic cardiomyocytes were stained with Annexin-V-fluorescein isothiocyanate(FITC),Hoechst 33342 and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL).The mitochondrial transmembrane potential of cardiomyocytes was assessed using a fluorescence microscope.The expression of Bcl-2,Bax,cytochrome C,apoptosis-induced factor(AIF),and caspase-3 was tested by Western blot analysis.Results:Our data demonstrated that MSC medium reduced H/R-induced cardiomyocyte apoptosis,increased the Bcl-2/Bax ratio,and reduced the release of cyto-chrome C and AIF from mitochondria into the cytosol.Conclusion:MSCs protected the cardiomyocytes from H/R-induced apoptosis through a mitochondrial pathway in a paracrine manner. | Mei-xiang XIANG Ai-na HE Jian-an WANG Chun GUI | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，8： | 7 |
| 9 | A WRKY transcription factor confers aluminum tolerance via regulation of cell wall modifying genes显示文摘Modification of cell wall properties has been considered as one of the determinants that confer aluminum(Al)tolerance in plants,while how cell wall modifying processes are regulated remains elusive.Here,we present a WRKY transcription factor WRKY47 involved in Al tolerance and root growth.Lack of WRKY47 significantly reduces,while overexpression of it increases Al tolerance.We show that lack of WRKY47 substantially affects subcellular Al distribution in the root,with Al content decreased in apoplast and increased in symplast,which is attributed to the reduced cell wall Al-binding capacity conferred by the decreased content of hemicellulose I in the wrky47-1 mutant.Based on microarray,real time-quantitative polymerase chain reaction and chromatin immunoprecipitation assays,we further show that WRKY47 directly regulates the expression of EXTENSIN-LIKE PROTEIN(ELP)and XYLOGLUCAN ENDOTRANSGLUCOSYLASE-HYDROLASES17(XTH17)responsible for cell wall modification.Increasing the expression of ELP and XTH17 rescued Al tolerance as well as root growth in wrky47-1 mutant.In summary,our results demonstrate that WRKY47 is required for root growth under both normal and Al stress conditions via direct regulation of cell wall modification genes,and that the balance of Al distribution between root apoplast and symplast conferred by WRKY47 is important for Al tolerance. | Chun Xiao Li Jing Ying Yan Jiang Yuan Ren Li Sun Chen Xu Gui Xin Li Zhong Jie Ding Shao Jian Zheng | 2020 | Journal of Integrative Plant Biology2020，62，8： | 7 |
| 10 | Preparation and characterization of hexadecane microcapsule with polyurea-melamine formaldehyde resin shell materials显示文摘This paper gives a brief report of the preparation of hexadecane microcapsule with polyurea-melamine formaldehyde resin shell materials(HMPM).The sealing performance and thermal stability of HMPM was enhanced much more effectively than that of microcapsule with polyurea shell material(HPM).The results of microscopical imaging analysis system,DSC,TG,and laser particle analyzer were briefly introduced. | Gao, Gui Bo Qian, Chun Xiang Gao, Min Jie | 2010 | Chinese Chemical Letters2010，21，5： | 5 |
| 11 | A novel approach for synthesis of 3-amino-5-aryl-2,5-dihydropyridazines using onium salt as soluble support显示文摘在这个工作,它被介绍任务的应用象对 3-amino-5-aryl-2,5-dihydropyridazines 的合成的可溶的支持咸的特定的 onium。这可溶的支持具有宽适用性并且没有它的限制,溶液阶段化学把稳固的阶段合成的优点与那些相结合。在一个简单的洗步骤以后,产品从支持被劈开并且在好收益获得了。 | Meng Gao Cui Fen Lu Gui Chun Yang Zu Xing Chen | 2011 | Chinese Chemical Letters2011，22，7： | 4 |
| 12 | The Besov Space B_1^(0.1) on Domains | Yi Qing GUI Shan Zhen LU Da Chun YANG Department of Mathematics. Beijing Normal University. Beijing 100875. P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，2： | 2 |
| 13 | SYNTHESIS OF NEW BENZOXEPINOQUINOLINOES显示文摘SYNTHESIS OF NEW BENZOXEPINOQUINOLINOESSYNTHESISOFNEWBENZOXEPINOQUINOLINOESYongJunGAO;ChunJieLI;BiShanJIANG;GuiJiJIANG(Depart... | Yong Jun GAO Chun Jie LI Bi Shan JIANG Gui Ji JIANG(Department of Chemistry,Yanbian university, Yanji, 133002) | 1994 | Chinese Chemical Letters1994，5，9： | 2 |
| 14 | Expression of heregulin and ErbB receptors in mesenchymal stem cells显示文摘背景:间充质的干细胞是为在心肌的梗塞的房间移植的一种有希望的房间类型。类型我 neuregulins-1,也作为 heregulin 知道,能支持 cardiomyocytes 和 stimulate 血管生成的幸存。这研究的目的是在间充质的干细胞调查 heregulin 和 ErbB 受体的表示,然后进一步在浆液剥夺和组织缺氧的条件下面在 heregulin 和 ErbB 受体的表示检测 heregulin 和变化的分泌物。方法:从 180 只 g 男性 Sprague-Dawley 老鼠的骨髓孤立的间充质的干细胞是有教养的。经过 3 房间被常规反向的 transcriptase 聚合酶链反应(RT-PCR ) 试验性地检测,量的实时 PCR 并且西方的弄污。结果:Heregulin 和 ErbB 受体在间充质的干细胞,和所有三 ErbB 受体 mRNA 表情被表示由浆液剥夺和组织缺氧是显著地下面调整的,但是浆液剥夺和组织缺氧显著地增加了 heregulin 的蛋白质表示。浆液剥夺和组织缺氧超过 12 个小时能导致 heregulin 的分泌物。结论:间充质的干细胞能表示所有三 ErbB 受体和 heregulin。浆液剥夺和组织缺氧减少 ErbB 受体的 mRNA 表示,增加 heregulin,和 activate 的表示 heregulin 的分泌物。 | GUI Chun WANG Jian-an HE Ai-na CHEN Tie-long LIU Xian-bao LUO Rong-hua JIANG Jun | 2008 | Chinese Medical Journal2008，，2： | 2 |
| 15 | Interference study on the free calcium in the human peripheral lymphocyte by acrylamide显示文摘人的外部淋巴细胞上的 acrylamide 的角色被扫描共焦的显微镜学技术和 fluo-3 的激光学习。fluo-3-Ca2+ 建筑群的明显的分离常数(Kd ) 的刻度价值作为 4.83 脳被获得 10 ? 7 mol/L。Acrylamide (< 54 渭 g /mL ) 在免费的细胞内部的钙集中唤起了上升[Ca2+] 我,以一种剂量依赖者方式。Acrylamide 导致了增加[Ca2+] 我详细被讨论。 | Hai Yan Wang Chun Gui Zhao Ye Hong Zhou Shao Min Shuang Chuan Dong | 2008 | Chinese Chemical Letters2008，19，6： | 1 |
| 16 | Operando Converting BiOCl into Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) for Efficient Electrocatalytic Reduction of Carbon Dioxide to Formate显示文摘Bismuth-based materials(e.g., metallic, oxides and subcarbonate) are emerged as promising electrocatalysts for converting CO_(2) to formate. However, Bio-based electrocatalysts possess high overpotentials, while bismuth oxides and subcarbonate encounter stability issues. This work is designated to exemplify that the operando synthesis can be an effective means to enhance the stability of electrocatalysts under operando CO_(2)RR conditions. A synthetic approach is developed to electrochemically convert Bi^(O)Cl into Cl-containing subcarbonate(Bi_(2)O_(2)(CO_(3))_(x)Cl_(y)) under operando CO_(2)RR conditions. The systematic operando spectroscopic studies depict that BiOCl is converted to Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) via a cathodic potential-promoted anion-exchange process. The operando synthesizedBi_(2)O_(2)(CO_(3))_(x)Cl_(y) can tolerate-1.0 V versus RHE, while for the wet-chemistry synthesized pure Bi_(2)O_(2)CO_(3),the formation of metallic Bio occurs at-0.6 V versus RHE. At-0.8 V versus RHE, Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) can readily attain a FEHCOO-of 97.9%,much higher than that of the pure Bi_(2)O_(2)CO_(3)(81.3%). DFT calculations indicate that differing from the pure Bi_(2)O_(2)CO_(3)-catalyzed CO_(2)RR, where formate is formed via a *OCHO intermediate step that requires a high energy input energy of 2.69 eV to proceed, the formation of H COO-over Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) has proceeded via a *COOH intermediate step that only requires low energy input of 2.56 eV. | Huai Qin Fu Junxian Liu Nicholas M.Bedford Yun Wang Joshua Wright Peng Fei Liu Chun Fang Wen Liang Wang Huajie Yin Dongchen Qi Porun Liu Hua Gui Yang Huijun Zhao | 2022 | Nano-Micro Letters2022，14，7： | 1 |
| 17 | Error Analysis and Compensation for Inductosyn based Position Measuring System显示文摘 | Du Chun yang Yang Gui jie | 2003 | IEEE2003，，： | 1 |
| 18 | Compari-son of proximal femoral nail antirotation blade and reverse lessinvasive stabilization system-distal femur systems in the treat-ment of proximal femoral fractures显示文摘 | NING HAN GUI XIN SUN ZENG CHUN LI | 2011 | Orthopaedic Surgery2011，3，1： | 1 |
| 19 | Thermal properties of poly(vinyl chloride)/montmorillonite nanocomposites 显示文摘 | GONG Fang Ling FENG Meng ZHAO Chun Gui | 2004 | Polym Degrad Stab2004，84，： | 1 |
| 20 | Study on the effects of cefotaxime on intracellular Ca^(2+) in human peripheral lymphocytes by fluoremetry显示文摘Characteristic of Fura-2-Ca^(2+)interaction was studied based on the fluorescence technique.The apparent dissociation constants(K_d)of the Fura-2-Ca^(2+)complex were determined at different temperature.The effect of cefotaxime(CEFA)on intracellular Ca^(2+)concentration([Ca^(2+)]_i)was discussed by using a ratiometric fluorescence dye Fura-2 as a probe.The basal[Ca^(2+)]_i in resting humanperipheral lymphocytes was 100 7 nmol/L but after treatment with cefotaxime,the changes of[Ca^(2+)]_i were observed in differentconditions.In the concentration range of 1-30 μmol/L of cefotaxime[Ca^(2+)]_i increased,as a result of releasing intracellular Ca2+stores.Higher concentration of cefotaxime(50-500 μmol/L)stimulated to decrease of[Ca^(2+)]_i. | Dan Dan Wang Hai Yan Wang Ye Hong Zhou Chun Gui Zhao Chuan Dong Shao Min Shuang | 2007 | Chinese Chemical Letters2007，18，4： | 1 |
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