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| 1 | An efficient method to synthesize HMX by nitrolysis of DPT with N_2O_5 and a novel ionic liquid显示文摘A novel polyethylene glycol(PEG)-200-based dicationic acidic ionic liquid(PEG_(200)-DAIL) was used to synthesize HMX from DPT by nitrolysis with N_2O_5.It was found that either N_2O_5 or PEG_(200)-DAIL could improve the yield.Furthermore,the combined use of PEG_(200)-DAIL and N_2O_5 could increase the yield of HMX to 64%with the used quantity of HNO_3 decreased dramatically. | Hui Zhen Zhi Jun Luo Guang An Feng Chun Xu Lv | 2009 | Chinese Chemical Letters2009，20，4： | 15 |
| 2 | Icariside Ⅱ inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway显示文摘β-amyloid(Aβ)is one of the inducing factors of astrocytes activation and neuroinflammation,and it is also a crucial factor for the development of Alzheimer’s disease(AD).Icariside II(ICS II)is an active component isolated from a traditional Chinese herb Epimedium,which has shown to attnuate lipopolysaccharide(LPS)-induced neuroinflammation through regulation of NF-κB signaling pathway.In this study we investigated the effects of ICS II on LPS-induced astrocytes activation and Aβaccumulation.Primary rat astrocytes were pretreated with ICS II(5,10,and 20μM)or dexamethasone(DXMS,1μM)for 1 h,thereafter,treated with LPS for another 24 h.We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),inducible nitric oxide synthase(iNOS),cyclooxygenase-2(COX-2)in the astrocytes.Moreover,ICS II not only exerted the inhibitory effect on LPS-induced IκB-αdegradation and NF-κB activation,but also decreased the levels of Aβ1–40,Aβ1–42,amyloid precursor protein(APP)and beta secretase 1(BACE1)in the astrocytes.Interestingly,molecular docking revealed that ICS II might directly bind to BACE1.It is concluded that ICS II has potential value as a new therapeutic agent to treat neuroinflammation-related diseases,such as AD. | Yong Zheng Yan Deng Jian-mei Gao Chun Lv Ling-hu Lang Jing-shan Shi Chang-yin Yu Qi-hai Gong | 2020 | Acta Pharmacologica Sinica2020，41，2： | 8 |
| 3 | Rare earth metal triflates catalyzed electrophilic nitration using N_2O_5显示文摘为 electrophilic 硝代的一个温和、有效、 eco 友好的过程面对稀土元素金属 triflates 用 N2O5 被描述为一个绿 nitrating 代理人[RE (OTf ) 3 ] 在温和条件下面。 | Xiao Ming Ma Bin Dong Li Ming Lu Chun Xu Lv | 2012 | Chinese Chemical Letters2012，23，1： | 7 |
| 4 | Selective nitration of aromatic compounds catalyzed by Hβ zeolite using N_2O_5显示文摘为 electrophilic 硝代的一个选择、有效的过程用 N2O5 被描述为一个绿 nitrating 代理人,是的 H 沸石在温和条件下面的稳固的酸催化剂和形状控制代理人。 | Xiao Ming Ma Bin Dong Li Lei Chen Ming Lu Chun Xu Lv | 2012 | Chinese Chemical Letters2012，23，7： | 7 |
| 5 | Towards context consistency by concurrent checking for Internetware applications显示文摘Internetware applications are emerging and being widely used.They can adapt their behavior based on environmental contexts and deliver smart services.These contexts can be subject to various noises,which cause them to be inaccurate,incomplete,or even to conflict with each other.This is known as context inconsistency problem.Context inconsistency can trigger unexpected behavior to applications,and therefore should be prevented.One promising approach is to check contexts against consistency constraints so as to detect the occurrences of context inconsistency at runtime.Existing techniques have attempted different ways to improve the checking efficiency or effectiveness with different trade-offs in space overhead or communication cost.However,none of them has exploited multi-core computing capability to systematically improve the checking efficiency.In this paper,we propose a novel concurrent checking technique Con-C to efficiently detect inconsistencies in huge volumes of dynamic contexts.Con-C derives checking subtasks for each consistency constraint based on its structure and semantics.It achieves this in a fully automated way,and at the same time can guarantee its derived checking subtasks to be persistently balanced.We evaluated Con-C by controlled experiments through a large-scale real-world application.It reported promising results that Con-C improved the checking efficiency by extra 57.0%,in addition to what had been gained by incremental checking. | XU Chang LIU YePang CHEUNG S.C. CAO Chun LV Jian | 2013 | Science China(Information Sciences)2013，56，8： | 5 |
| 6 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 7 | Acrosin structure-based design,synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors显示文摘一系列 7-azaindol 衍生物基于人的精子酵素的相应 3D 模型被设计。这些混合物被综合并且在 vitro 为他们的人的精子酵素评估了禁止的活动。混合物 7a, 7i, 7j, 7k 和 7n 对人的精子酵素显示出高度禁止的活动。三维的 structureactivity 关系通过一个 CoMFA 模型被调查,它提供了珍贵信息推进潜在的人的精子酵素禁止者的学习。 | Jun Hang Jiang Xue Fei Liu Can Hui Zhen You Jun Zhou Ju Zhu Jia Guo Lv Chun Quan Sheng | 2011 | Chinese Chemical Letters2011，22，3： | 3 |
| 8 | Catalytic ozonation performance and surface property of supported Fe304 catalysts dispersions显示文摘 | Zhendong YANG Aihua LV Yulun NIE Chun HU | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 3 |
| 9 | O-glycosyltransferases from Homo sapiens contributes to the biosynthesis of Glycyrrhetic Acid 3-O-mono-β-D-glucuronide and Glycyrrhizin in Saccharomyces cerevisiae显示文摘Glycyrrhizin(GL)and Glycyrrhetic Acid 3-O-mono-β-D-glucuronide(GAMG)are the typical triterpenoid glycosides found in the root of licorice,a popular medicinal plant that exhibits diverse physiological effects and pharmacological manifestations.However,only few reports are available on the glycosylation enzymes involved in the biosynthesis of these valuable compounds with low conversion yield so far.In mammals,glycosyltransferases are involved in the phase II metabolism and may provide new solutions for us to engineer microbial strains to produce high valued compounds due to the substrate promiscuity of these glycosyltransferases.In this study,we mined the genomic databases of mammals and evaluated 22 candidate genes of O-glycosyltransferases by analyzing their catalytic potential for O-glycosylation of the native substrate,glycyrrhetinic acid(GA)for its glycodiversification.Out of 22 selected glycosyltransferases,only UGT1A1 exhibited high catalytic performance for biosynthesis of the key licorice compounds GL and GAMG.Molecular docking results proposed that the enzymatic activity of UGT1A1 was likely owing to the stable hydrogen bonding interactions and favorite conformations between the amino acid residues around substrate channels(P82~R85)and substrates.Furthermore,the complete biosynthesis pathway of GL was reconstructed in Saccharomyces cerevisiae for the first time,resulting in the production of 5.98±0.47 mg/L and 2.31±0.21 mg/L of GL and GAMG,respectively. | Ke Xu Yu-jia Zhao Nadeem Ahmad Jing-nan Wang Bo Lv Ying Wang Jun Ge Chun Li | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 3 |
| 10 | Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China显示文摘Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.Methods: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.Results: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of < 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of < 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced.Conclusions: Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. | Xiao‑Lei Ye Ke Dai Qing‑Bin Lu Yan‑Qin Huang Shou‑Ming Lv Pan‑He Zhang Jia‑Chen Li Hai‑Yang Zhang Zhen‑Dong Yang Ning Cui Chun Yuan Kun Liu Xiao‑Ai Zhang Jiu‑Song Zhang Hao Li Yang Yang Li‑Qun Fang Wei Liu | 2021 | Infectious Diseases of Poverty2021，10，6： | 3 |
| 11 | Converting Co^(2+)-impregnated g-C_(3)N_(4) into N-doped CNTs-confined Co nanoparticles for efficient hydrogenation rearrangement reactions of furanic aldehydes显示文摘The cyclopentanone and derivatives are a class of crucial fine chemicals for various industries and currently produced by conventional petrochemical synthetic routes.Here,we demonstrated a new synthetic approach to directly fabricate N-doped carbon nanotube(N-CNTs)networks with confined Co nanoparticles from Co^(2+)-impregnated bulk g-C_(3)N_(4) as high performance hydrogenation rearrangement(HR)catalyst to efficiently convert a wide spectrum of biomass-derived furanic aldehydes to the corresponding cyclopentanones in water under a record-low H2 pressure of 0.5 MPa and mild temperature.We unveiled a Co-catalysed bulk g-C_(3)N_(4) decomposition/carbonisation CNTs formation mechanism.A new HR pathway was also unveiled. | Dongdong Wang Mohammad Al-Mamun Wanbing Gong Yang Lv Chun Chen Yue Lin Guozhong Wang Haimin Zhang Huijun Zhao | 2021 | Nano Research2021，14，8： | 2 |
| 12 | Characteristics of the quasi-16-day wave in the mesosphere and lower thermosphere region as revealed by meteor radar,Aura satellite,and MERRA2 reanalysis data from 2008 to 2017显示文摘This study presents an analysis of the quasi-16-day wave(Q16DW)at three stations in the middle latitudes by using a meteor radar chain in conjunction with Aura Microwave Limb Sounder temperature data and MERRA2(Modern-Era Retrospective Analysis for Research and Applications,Version 2)reanalysis data from 2008 to 2017.The radar chain consists of three meteor radar stations located at Mohe(MH,53.5°N,122.3°E),Beijing(BJ,40.3°N,116.2°E),and Wuhan(WH,30.5°N,114.6°E).The Q16DW wave exhibits similar seasonal variation in the neutral wind and temperature,and the Q16DW amplitude is generally strong during winter and weak around summer.The Q16DW at BJ was found to have secondary enhancement around September in the zonal wind,which is rarely reported at similar latitudes.The latitudinal variations of the Q16DW in the neutral wind and temperature are quite different.The Q16DW at BJ is the most prominent in both neutral wind components among the three stations and the Q16DW amplitudes at MH and WH are comparable,whereas the wave amplitude in temperature decreases with decreasing latitude.The quasi-geostrophic refractive index squared at the three stations in the period from 2008 to 2017 was revealed.The results indicate that the Q16DW in the mesosphere and lower thermosphere(MLT)at MH has a limited contribution from the lower atmosphere.Around March and October,the Q16DW in the troposphere at BJ can propagate upward into the MLT region,whereas at WH,the contribution to the Q16DW in the MLT region is largely from the mesosphere. | Yun Gong Zheng Ma Chun Li XieDong Lv ShaoDong Zhang QiHou Zhou ChunMing Huang KaiMing Huang You Yu GuoZhu Li | 2020 | Earth and Planetary Physics2020，4，3： | 2 |
| 13 | Density Functional Theoretical Studies on the Methanol Adsorption and Decomposition on Ru(0001) Surfaces显示文摘 | LIU Jianhong LV Cunqin JIN Chun GUO Yong WANG Guichang | 2016 | Chemical Research in Chinese Universities2016，32，2： | 2 |
| 14 | Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives显示文摘Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions.The structures of these novelly synthesized compounds were verified by ~1H NMR,ESI-MS and single crystal X-ray diffraction.Furthermore,all four compounds(most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG2 2.2.15 cell,making them promising drug candidates for potential bioactive molecule against hepatitis B. | Zhang, Yi Kai Lv, Zhi Liang Niu, Chun Juan Li, Ke | 2010 | Chinese Chemical Letters2010，21，3： | 2 |
| 15 | Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death显示文摘AIM To describe the prevalence of posttransplant metabolic syndrome(PTMS) after donation after cardiac death(DCD) liver transplantation(LT) and the pre-and postoperative risk factors.METHODS One hundred and forty-seven subjects who underwent DCD LT from January 2012 to February 2016 were enrolled in this study. The demographics and the clinical characteristics of pre-and post-transplantation were collected for both recipients and donors. PTMS was defined according to the 2004 Adult Treatment Panel-Ⅲ criteria. All subjects were followed monthly for the initial 6 mo after discharge, and then, every 3 mo for 2 years. The subjects were followed every 6 mo or as required after 2 years post-LT.RESULTS The prevalence of PTMS after DCD donor orthotopic LT was 20/147(13.6%). Recipient's body mass index(P = 0.024), warm ischemia time(WIT)(P = 0.045), and posttransplant hyperuricemia(P = 0.001) were significantly associated with PTMS. The change in serum uric acid levels in PTMS patients was significantly higher than that in non-PTMS patients(P < 0.001). After the 1 s t mo, the level of serum uric acid of PTMS patients rose continually over a period, while it was unaltered in non-PTMS patients. After transplantation, the level of serum uric acid in PTMS patients was not associated with renal function.CONCLUSION PTMS could occur at early stage after DCD LT with growing morbidity with the passage of time. WIT and post-LT hyperuricemia are associated with the prevalence of PTMS. An increased serum uric acid level is highly associated with PTMS and could act as a serum marker in this disease. | Liang-Shuo Hu Yi-Chao Chai Jie Zheng Jian-Hua Shi Chun Zhang Min Tian Yi Lv Bo Wang Ai Jia | 2018 | World Journal of Gastroenterology2018，24，43： | 2 |
| 16 | Combination Use of PFGE and Drug-resistant Analysis in the Epidemiological Investigation of Listeria Monocytogenes显示文摘Listeria monocytogenes is the pathogen of listeriosis and it causes severe infections like septicemia,encephalitis,and meningitis,especially in immunocompromised individuals,newborns,and pregnant women.Its wide distribution in the environment and ability to survive or even | LV Jun ZHENG Xiang Mei CHENG Shi Xiu ZHENG Hua Ying ZENG Ying Chun | 2013 | Biomedical and Environmental Sciences2013，26，4： | 2 |
| 17 | High-speed countercurrent chromatography for purification of single-walled carbon nanotubes显示文摘用高速度的逆流层析的围单人赛的碳 nanotubes 的新色析法的纯化被报导。纯化根据与钠 dodecyl 硫酸盐驱散围单人赛的碳 nanotubes 的实验被完成,并且结果混合用由 n-butanol/water = 1/1 (v/v ) 组成的二个阶段系统被分开。分开的 SWNT 的尺寸被扫描电子显微镜学观察。结果证明高速度的逆流层析为围单人赛的碳 nanotubes 的纯化拥有了好 efficency。 | Ying Cai Zhi Hong Yan Ying Chun Lv Min Zi Li Ming Yuan | 2008 | Chinese Chemical Letters2008，19，11： | 2 |
| 18 | Highly selective hydrogenation of halonitroaromatics to aromatic haloamines by ligand modified Ni-based catalysts显示文摘由到 Ni 金属的 dicyandiamide 的协作的基于 Ni 的催化剂的 Ligand 修正为 halonitroaromatics 的选择加氢导致提高的选择。选择超过 99.9% ,到芳香的 haloamines,罐头在 100% 的变换被完成。H2TPD 和英尺红外实验的结果证明在 Raney Ni 的表面上拥有路易斯酸地点的性质的 NiH+ 种类能为 hydrodehalogenation 负责。当 Raney Ni 被 dicyandiamide 对待时, NiH+ 种类从 dicyandiamide 与 N 原子交往了。这个相互作用甚至在反应温度是稳定的,它减少了可能性形成 ArClH+Ni 的中间的状态。然后 CCl 债券不能被极化并且激活。hydrodechlorination 过程有效地被压制。 | Chun Shan Lu Jing Hui Lv Lei Ma Qun Feng Zhang Feng Feng Xiao Nian Li | 2012 | Chinese Chemical Letters2012，23，5： | 2 |
| 19 | Topographies of Organized Monolayer of α-Amylase Observed by Atomic Force Microscopy显示文摘In this paper, (-amylase organized monolayer was assembled on the surface of the PET-CO2- substrate in different conditions. The different topography of the (-amylase/PET monolayer was obtained by AFM in tapping mode. | Lin HE, Xian Fu LIN*, De Shui LV, Zhi Chun CHEN Institute of Applied Chemistry of Zhejiang University, Hangzhou 310027 | 2001 | Chinese Chemical Letters2001，12，1： | 1 |
| 20 | Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine‑resistant treatment‑refractory schizophrenia:a 12‑week randomized,double‑blind,placebo‑controlled trial显示文摘Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine.The main purpose of this randomized,double-blind,placebocontrolled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of clozapine-resistant treatment-refractory schizophrenia(CTRS)patients.Methods:A total of 80 patients were recruited and randomly assigned to receive initial clozapine plus amisulpride(amisulpride group)or clozapine plus placebo(placebo group).Positive and Negative Syndrome Scale(PANSS),Scale for the Assessment of Negative Symptoms(SANS),Clinical Global Impression(CGI)scale scores,Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Treatment Emergent Symptom Scale(TESS),laboratory measurements,and electrocardiograms(ECG)were performed at baseline,week 6,and week 12.Results:Compared with the placebo group,amisulpride group had a lower PANSS total score,positive subscore,and general psychopathology subscore at week 6 and week 12(PBonferroni<0.01).Furthermore,compared with the placebo group,the amisulpride group showed an improved RBANS language score at week 12(PBonferroni<0.001).Amisulpride group had a higher treatment response rate(P=0.04),lower scores of CGI severity and CGI efficacy at week 6 and week 12 than placebo group(PBonferroni<0.05).There were no differences between the groups in body mass index(BMI),corrected QT(QTc)intervals,and laboratory measurements.This study demonstrates that amisulpride augmentation therapy can safely improve the psychiatric symptoms and cognitive performance of CTRS patients. | Ming‑Huan Zhu Zhen‑Jing Liu Qiong‑Yue Hu Jia‑Yu Yang Ying Jin Na Zhu Ying Huang Dian‑Hong Shi Min‑Jia Liu Hong‑Yang Tan Lei Zhao Qin‑Yu Lv Zheng‑Hui Yi Feng‑Chun Wu Ze‑Zhi Li | 2023 | Military Medical Research2023，10，4： | 1 |
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