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| 1 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 2 | Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model显示文摘Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer. | Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，12： | 2 |
| 3 | Tandem Synthesis of Photoactive Benzodifuran Moieties in the Formation of Microporous Organic Networks显示文摘 | Narae Kang Ji Hoon Park Kyoung Chul Ko Jiseul Chun Eunchul Kim Hee‐Won Shin Sang Moon Lee Hae Jin Kim Tae Kyu Ahn Jin Yong Lee Seung Uk Son | 2013 | Angew. Chem. Int. Ed2013，，24： | 1 |
| 4 | A novel startup scheme of stator-flux-oriented vector-contr-olled induction motor drive without torque jerk显示文摘 | Chun Tae Won Choi Meong Kyu Bose B K | 2003 | Industry Applications IEEE Transactions2003，，： | 1 |
| 5 | Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation显示文摘 | In Duk Jung Jun Sik Lee Chang-Min Lee Kyung Tae Noh Yeong-Il Jeong Won Sun Park Sung Hak Chun Soo Kyung Jeong Jin Wook Park Kwang Hee Son Deok Rim Heo Min-Goo Lee Yong Kyoo Shin Han Wool Kim Cheol-Heui Yun Yeong-Min Park | 2010 | Biochemical Pharmacology2010，，： | 1 |
| 6 | Microstructural Behavior of Rapidly Solidified and Extruded A1 -- 14wt%Ni -- 14wt%Mm (Mm,Misch Metal) Alloy Powders显示文摘 | Soon Jik Hong Taek - Soo Kim Hyoung Seop Kim Won Tae Kim Byong Sun Chun | 1999 | Materials Science and Engineering A1999，271，： | 1 |
| 7 | Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus显示文摘Oenanthe javanica is an aquatic perennial herb that belongs to the Oenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glutamate-induced neurotoxicity. However, few studies regarding effects of Oenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract of Oenanthe javanica on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67(an endogenous marker for cell proliferation) and doublecortin(a marker for neuroblast). Our results showed that Oenanthe javanica extract significantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was significantly increased in the dentate gyrus of the Oenanthe javanica extract-treated group compared with the control group. However, we did not find that vascular endothelial growth factor expression was increased in the Oenanthe javanica extract-treated group compared with the control group. These results indicate that Oenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-derived neurotrophic factor immunoreactivity in the rat dentate gyrus. | Bai Hui Chen Joon Ha Park Jeong Hwi Cho In Hye Kim Bich Na Shin Ji Hyeon Ahn Seok Joon Hwang Bing Chun Yan Hyun Jin Tae Jae Chul Lee Eun Joo Bae Yun Lyul Lee Jong Dai Kim Moo-Ho Won Il Jun Kang | 2015 | Neural Regeneration Research2015，10，2： | 1 |
| 8 | A novel start-up scheme of stator flux oriented vector controlled induction motor drive without torque jerk显示文摘 | Chun Tae Won Choi Meong kyu | 2003 | IEEE Transactions on Industry Applications2003，39，3： | 1 |
| 9 | A novel strategy of efficiency control for a linear compressor system driven by a PWM inverter显示文摘 | Chun Tae - Won Ahn Jung - Ryol | 2008 | IEEE Transactions on Industri- al Electronics2008，55，1： | 1 |
| 10 | Corrigendum to “Development and characterization of a colon PDX model that reproduces drug responsiveness and the mutation profiles of its original tumor” [Cancer Lett. 345 (1) (2014) 56–64]显示文摘 | Hyang Sook Seol Hyo Jeong Kang Seul-I. Lee Na Eun Kim Tae Im Kim Sung Min Chun Tae Won Kim Chang Sik Yu Young-Ah Suh Shree Ram Singh Suhwan Chang Se Jin Jang | 2014 | Cancer Letters2014，，： | 1 |
| 11 | Reconstruction of inferior right hepatic veins in living donor liver transplantation using right liver grafts显示文摘 | Shin Hwang Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Ki‐Hun Kim Gi‐Won Song Dong‐Hwan Jung Gil‐Chun Park Jung‐Man Namgoong Sung‐Won Jung Sam‐Youl Yoon Kyu‐Bo Sung Gi‐Young Ko Byungchul Cho Kyoung Won Kim Sung‐Gyu Lee | 2012 | Liver Transpl2012，，2： | 1 |
| 12 | Hemodynamics‐compliant reconstruction of the right hepatic vein for adult living donor liver transplantation with a right liver graft显示文摘 | Shin Hwang Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Gi‐Won Song Ki‐Hun Kim Dong‐Hwan Jung Gil‐Chun Park Kyu‐Bo Sung Gi‐Young Ko Kyoung Won Kim Byungchul Cho Jung‐Man Namgoong Sung‐Won Jung Sam‐Youl Yoon Chun‐Soo Park Yo‐Han Park Hyeong‐Woo Park Hyo‐Jun Lee | 2012 | Liver Transpl2012，，7： | 1 |
| 13 | A novel start-up scheme of stator flux oriented vector controlled induction motor drive without torque jerk显示文摘 | Tae Won Chun Meong Kyu Choi | 2003 | IEEE Transactions on Industry Applications2003，39，3： | 1 |
| 14 | Usability of ringed polytetrafluoroethylene grafts for middle hepatic vein reconstruction during living donor liver transplantation显示文摘 | Shin Hwang Dong‐Hwan Jung Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Ki‐Hun Kim Gi‐Won Song Gil‐Chun Park Sung‐Won Jung Sam‐Youl Yoon Jung‐Man Namgoong Chun‐Soo Park Yo‐Han Park Hyeong‐Woo Park Hyo‐Jun Lee Sung‐Gyu Lee | 2012 | Liver Transpl2012，，8： | 1 |
| 15 | An improved control strategy using a PI-resonant controller for an unbal-anced stand-alone doubly-fed induction generator显示文摘 | Van Tung Phan Hong Hee Lee Tae Won Chun | 2010 | Journal of Power Electronics2010，10，2： | 1 |
| 16 | Comparison of the characteristics of submucosal injection solutions used in endoscopic mucosal resection显示文摘 | Jong Jin Hyun Hwang Rae Chun Hoon Jai Chun Yoon Tae Jeen Chang Won Baeck Sang Kyun Yu Yong Sik Kim Hong Sik Lee Soon Ho Um Sang Woo Lee Jai Hyun Choi Chang Duck Kim Ho Sang Ryu Jin Hai Hyun | 2006 | Scandinavian Journal of Gastroenterology2006，，4： | 1 |
| 17 | Biological activities of the polysaccharides produced from submerged culture of the edible Basidiomycete Grifola frondosa显示文摘 | Bum Chun Lee Jun Tae Bae Hyeong Bae Pyo Tae Boo Choe Sang Woo Kim Hye Jin Hwang Jong Won Yun | 2003 | Enzyme and Microbial Technology2003，，5： | 1 |
| 18 | Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus显示文摘The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions(CA1–3) between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia. p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group. p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults. | Eun Joo Bae Bai Hui Chen Bing Chun Yan Bich Na Shin Jeong Hwi Cho In Hye Kim Ji Hyeon Ahn Jae Chul Lee Hyun-Jin Tae Seongkweon Hong Dong Won Kim Jun Hwi Cho Yun Lyul Lee Moo-Ho Won Joon Ha Park | 2015 | Neural Regeneration Research2015，10，6： | 0 |
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