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| 1 | 克罗恩病:CT小肠成像、MR小肠成像和小肠灌肠造影的比较显示文摘目的前瞻性比较CT和MR小肠成像及小肠灌肠造影3种检查方法发现克罗恩病病人活动性小肠炎症和肠外并发症的准确性。方法机构伦理审查委员会批准本研究计划,并所有参与者知情同意。对连续31例克罗恩病或疑有克罗恩病的病人行CT和MR小肠成像、小肠灌肠造影和回肠结肠镜检查。2位独立的阅片者回顾CT和MR小肠成像及小肠灌肠造影影像以确定活动性末端回肠炎和肠道外并发症的存在。以回结肠镜检查结果作为参考标准,利用受试者工作特性曲线方法来评估CT和MR小肠成像及小肠灌肠造影确定活动性末端回肠炎的准确度。 | S.S. Lee A.Y. Kim S.K. Yang J. W. Chung S.Y. Kim S.H. Park 孙东辉(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 57 |
| 2 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 3 | Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line显示文摘瞄准:与它行动的分子的机制调查在小檗硷和 apoptotic 小径的禁止的生长(细胞毒素的活动) 之间的关系。方法:在试管内细胞毒素的技术被房间周期分析和 sub-G1 的决心在人的胃的癌 SNU-5 房间为 apoptosis 补充。可行房间,房间周期,和 sub-G1 组(apoptosis ) 的百分比被流动 cytometric 方法检验并且决定。为房间周期拘捕和 apoptosis 的联系蛋白质被西方的弄污检验。结果:为 SNU-5 房间线, IC50 被发现是小檗硷的 48 micromol/L。在与 25-200 micromol/L 小檗硷对待的 SNU-5 房间, G2/M 房间周期拘捕被观察它与 p53, Wee1 和 CDk1 蛋白质和减少的 cyclin 的表示的显著增长被联系 B。在 G0/G1 阶段的房间和 G2/M 阶段的增加的集中依赖者减少被检测。另外,当在房间周期测量的 sub-G0 房间人口被监视 apoptotic 小径在 25-200 micromol/L 证明对待 berberine 的房间, apoptosis 检测了。 Apoptosis 被 sub-G0 房间人口识别,并且在 Bcl-2 的规定下面,Ca2+在 Bax 的规定上面释放,减少 mitochondrial 膜电位然后导致了 mitochondrial 细胞色素 C 的版本进细胞质并且引起了 caspase-3 的激活,并且最后导致了 apoptosis 的出现。结论:小檗硷导致 p53 表示并且为 apoptosis 的正式就职导致 mitochondrial 膜电位,细胞色素 C 版本和 caspase-3 的激活的减少。 | Jing-Pin Lin Jai-Sing Yang Jau-Hong Lee Wen-Tsong Hsieh Jing-Gung Chung | 2006 | World Journal of Gastroenterology2006，12，1： | 34 |
| 4 | 8-Hydroxydeoxyguanosine:Not mere biomarker for oxidative stress,but remedy for oxidative stress-implicated gastrointestinal diseases显示文摘Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG),which can bind to thymidine rather than cytosine,based on which,the level of 8-OHdG is gen-erally regarded as a biomarker of mutagenesis conse-quent to oxidative stress.For example,higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer.However,we have found that exogenous 8-OHdG can paradoxically reduce ROS production,attenuate thenuclear factor-κB signaling pathway,and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1,IL-6,cyclo-oxygenase-2,and induc-ible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1,NOX organizer-1 and NOX activator-1 in vari-ous conditions of inflammation-based gastrointestinal (GI) diseases including gastritis,inflammatory bowel disease,pancreatitis,and even colitis-associated carci-nogenesis.Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases,as well as the pre-vention of inflammation-associated GI cancer.In this editorial review,the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced. | Chan-Young Ock Eun-Hee Kim Duck Joo Choi Ho Jae Lee Ki-Baik Hahm Myung Hee Chung | 2012 | World Journal of Gastroenterology2012，18，4： | 30 |
| 5 | Recent Advances in Cuticular Wax Biosynthesis and Its Regulation in Arabidopsis显示文摘The aerial parts of land plants are covered with cuticular waxes that limit non-stomatal water loss and gaseous exchanges,and protect plants from ultraviolet radiation and pathogen attacks.They are composed of very-long-chain fatty acids (VLCFAs;C20 to C34) in addition to their derivatives,aldehydes,alkanes,primary and secondary alcohols,and wax esters.Due to their physical properties,such as solidity at room temperature and a translucency ranging from transparent to opaque,plant waxes have been used as raw materials in the production of cosmetics,detergents,plastics,soaps,paints,drugs,lubricants,and high-value renewable fuels.Many genes involved in cuticular wax biosynthesis and export have been characterized by forward and reverse genetic approaches as well as by stem epidermis transcriptome analysis.The regulatory mechanisms of cuticular wax biosynthesis have been reported at the transcriptional,posttranscriptional,and translational levels.Recent advances in cuticular wax biosynthesis and its regulation are reviewed in this paper. | Saet Buyl Lee Mi Chung Suh | 2013 | Molecular Plant2013，6，2： | 24 |
| 6 | Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells显示文摘AIM: The genes were divided into seven categories according to biological function; apoptosis-reiated, immune response-related, signal transduction-related, cell cyclerelated, cell growth-related, stress response-related and transcription-related genes.METHODS: We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL,24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR. RESULTS: Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE114), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.CONCLUSION: These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells,and might be used for therapeutic anticancer drug. | Hae-Jeong Park Seo-Hyun Yoon Long-Shan Han Long-Tai Zheng Kyung-Hee Jung Yoon-Kyung Uhm Je-Hyun Lee Ji-Seon Jeong Woo-Sang Joo Sung-Vin Yim Joo-Ho Chung Seon-Pyo Hong | 2005 | World Journal of Gastroenterology2005，11，33： | 23 |
| 7 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 8 | The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis显示文摘The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly understood.Functional analysis was performed on AtCOL4,an Arabidopsis thaliana L.CONSTANS-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation domain.Analyses of an AtCOL4 promoter-b-glucuronidase(GUS) construct revealed substantial GUS activity in whole seedlings.The expression of AtCOL4 was strongly induced by abscisic acid(ABA),salt,and osmotic stress.Mutation in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening process.In contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild type.Interestingly,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 mutant.Thus,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling pathway.Taken together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress. | Ji-Hee Min Jung-Sung Chung Kyeong-Hwan Lee Cheol Soo Kim | 2015 | Journal of Integrative Plant Biology2015，57，3： | 23 |
| 9 | Chronic gastrointestinal symptoms and quality of life in the Korean population显示文摘AIM: To evaluate the prevalence of chronic gastroin-testinal symptoms and their impact on health-related quality of life (HRQOL) in the Korean population. METHODS: A cross-sectional survey, using a reliable and valid Rome Ⅱ based questionnaire, was per-formed on randomly selected residents, between 18 and 69 years in age. All respondents were interviewed at their homes or offices by a team of interviewers. The impact of chronic gastrointestinal symptoms on HRQOL was assessed using the Korean version of the 36-item Short-Form general health survey (SF-36). RESULTS: Of the 1807 eligible subjects, 1417 (78.4%: male 762; female 655) were surveyed. Out of the respondents, 18.6% exhibited at least one chronic gastrointestinal symptom. The prevalence of gastro- esophageal reflux disease (GERD), defined as heart- burn and/or acid regurgitation experienced at least weekly, was 3.5% (95% CI, 2.6-4.5). The prevalence of uninvestigated dyspepsia, irritable bowel syndrome (IBS) and chronic constipation based on Rome Ⅱ cri- teria were 11.7% (95% CI, 10.1-13.5), 2.2% (95%CI, 1.5-3.1), and 2.6% (95% CI, 1.8-3.5) respectively. Compared with subjects without chronic gastrointesti- nal symptoms (n = 1153), those with GERD (n = 50), uninvestigated dyspepsia (n = 166) and IBS (n = 31) had signifi cantly worse scores on most domains of the SF-36 scales. CONCLUSION: The prevalence of GERD, uninvesti-gated dyspepsia and IBS were 3.5%, 11.7% and 2.2% respectively, in the Korean population. The health- related quality of life was signifi cantly impaired in sub-jects with GERD, uninvestigated dyspepsia and IBS in this community. | Jeong-Jo Jeong Myung-Gyu Choi Young-Seok Cho Seung-Geun Lee Jung-Hwan Oh Jae-Myung Park Yu-Kyung Cho In-Seok Lee Sang-Woo Kim Sok-Won Han Kyu-Yong Choi In-Sik Chung | 2008 | World Journal of Gastroenterology2008，14，41： | 21 |
| 10 | Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease显示文摘Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ 25-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer's disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume,while Ellman method showed significant decrease in the activity of acetylcholinesterase in all three regions (prefrontal cortex,medial septum and hippocampus). These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer's disease. | Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-Hee Lee Soo-Wan Chae Sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung | 2013 | Neural Regeneration Research2013，8，12： | 21 |
| 11 | Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy显示文摘AIM:To investigate the efficacy of premedication with pronase,a proteolytic enzyme,in improving imagequality during magnifying endoscopy.METHODS:The study was of a blinded,randomized,prospective design.Patients were assigned to groups administered oral premedication of either pronase and simethicone(Group A)or simethicone alone(Group B).First,the gastric mucosal visibility grade(1-4)was determined during conventional endoscopy,and then a magnifying endoscopic examination was conducted.The quality of images obtained by magnifying endoscopy at the stomach and the esophagus was scored from1 to 3,with a lower score indicating better visibility.The endoscopist used water flushes as needed to obtain satisfactory magnifying endoscopic views.The main study outcomes were the visibility scores during magnifying endoscopy and the number of water flushes.RESULTS:A total of 144 patients were enrolled,and data from 143 patients(M:F=90:53,mean age 57.5 years)were analyzed.The visibility score was significantly higher in the stomach following premedication with pronase(73%with a score of 1 in Group A vs 49%in Group B,P<0.05),but there was no difference in the esophagus visibility scores(67%with a score of 1in Group A vs 58%in Group B).Fewer water flushes[mean 0.7±0.9 times(range:0-3 times)in Group A vs 1.9±1.5 times(range:0-6 times)in Group B,P<0.05]in the pronase premedication group did not affect the endoscopic procedure times[mean 766 s(range:647-866 s)for Group A vs 760 s(range:678-854 s)for Group B,P=0.88].The total gastric mucosal visibility score was also lower in Group A(4.9±1.5 vs 8.3±1.8in Group B,P<0.01).CONCLUSION:The addition of pronase to simethicone premedication resulted in clearer images during magnifying endoscopy and reduced the need for water flushes. | Gwang Ha Kim Yu Kyung Cho Jae Myung Cha Sun-Young Lee Il-Kwun Chung | 2015 | World Journal of Gastroenterology2015，21，8： | 21 |
| 12 | Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma显示文摘AIM To clarify the role of neoadjuvant concurrent chemoradiotherapy(NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma(CCA).METHODS We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows:(1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or(2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging. RESULTS The median disease-free survival(DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were26.0 and 15.1 mo, respectively(P = 0.91). The median overall survival(OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively(P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis(P = 0.01). CONCLUSION NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability. | Jang Han Jung Hyun Jik Lee Hee Seung Lee Jung Hyun Jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin Bang | 2017 | World Journal of Gastroenterology2017，23，18： | 21 |
| 13 | Role of oxygen free radicals in patients with acute pancreatitis显示文摘The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis.The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis.METHODS: The plasma levels of C-reactive protein (CRP),lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers.RESULTS: Among the patients with acute pancreatitis, there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stress no matter what the etiology was. The LPO level was especially correlated with the concentration of serum CRP and CT severity index.CONCLUSION: The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of plasma LPO is a meaningful index for determining the severity of the disease. | Byung Kyu Park Jae Bock Chung Jin Heon Lee Jeong Hun Suh Seung Woo Park Si Young Song Hyeyoung Kim Kyung Hwan Kim Jin Kyung Kang | 2003 | World Journal of Gastroenterology2003，9，10： | 18 |
| 14 | Genome-Wide Analysis and Molecular Characterization of Heat Shock Transcription Factor Family in Glycine max显示文摘Heat shock transcription factors (Hsfs) play an essential role on the increased tolerance against heat stress by regulating the expression of heat-responsive genes. In this study, a genome-wide analysis was performed to identify all of the soybean (Glycine max) GmHsf genes based on the latest soybean genome sequence. Chromosomal location, protein domain, motif organization, and phylogenetic relationships of 26 non-redundant GmHsf genes were analyzed compared with AtHsfs (Arabidopsis thaliana Hsfs). According to their structural features, the predicted members were divided into the previously defined classes A-C, as described for AtHsfs. Transcript levels and subcellular localization of five GmHsfs responsive to abiotic stresses were analyzed by real-time RT-PCR. These results provide a fundamental clue for understanding the complexity of the soybean GmHsf gene family and cloning the functional genes in future studies. | Eunsook Chung Kyoung-Mi Kim Jai-Heon Lee | 2013 | Journal of Genetics and Genomics2013，40，3： | 17 |
| 15 | Robotic surgery for rectal cancer: A systematic review of current practice显示文摘AIM: To give a comprehensive review of current litera-ture on robotic rectal cancer surgery.METHODS: A systematic review of current literature via PubMed and Embase search engines was per-formed to identify relevant articles from january 2007 to november 2013. The keywords used were: 'robotic surgery', 'surgical robotics', 'laparoscopic computer-assisted surgery', 'colectomy' and 'rectal resection'. RESULTS: After the initial screen of 380 articles, 20 pa-pers were selected for review. A total of 1062 patients(male 64.0%) with a mean age of 61.1 years and body mass index of 24.9 kg/m2 were included in the review.Out of 1062 robotic-assisted operations, 831(78.2%) anterior and low anterior resections, 132(12.4%) in-tersphincteric resection with coloanal anastomosis, 98(9.3%) abdominoperineal resections and 1(0.1%) Hart-mann's operation were included in the review. Robotic rectal surgery was associated with longer operative time but with comparable oncological results and anastomotic leak rate when compared with laparoscopic rectal surgery. CONCLUSION: Robotic colorectal surgery has con-tinued to evolve to its current state with promising re-sults; feasible surgical option with low conversion rate and comparable short-term oncological results. The challenges faced with robotic surgery are for more high quality studies to justify its cost. | Tony Wing Chung Mak Janet Fung Yee Lee Kaori Futaba Sophie Sok Fei Hon Dennis Kwok Yu Ngo Simon Siu Man Ng | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 16 |
| 16 | bcl-2 基因在良性前列腺增生中的作用显示文摘利用前列腺组织特异性的基因载体新型C3(1)和转基因技术,培植出人bcl2基因的前列腺组织特异性转基因鼠。免疫组织化学检测证实人bcl2蛋白在鼠前列腺上皮细胞中的过量表达。病理学观察发现,转基因鼠已发生良性前列腺增生。该实验为说明bcl2基因在良性前列腺增生(BPH)中的病理作用提供了最直接的证据,并繁殖出可稳定传代的BPH的动物模型。 | 张学军 Chung Lee Carl Olsson Ralph Buttyan 马腾骧 | 1997 | 中华泌尿外科杂志1997，18，2： | 15 |
| 17 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 18 | Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit显示文摘Indole-3-acetic 酸(IAA ) ,主要植物植物生长素,在色氨酸依赖者和色氨酸无关的小径被生产。在 Arabidopsis thaliana 的一条主要小径从色氨酸在二反应产生 IAA。步骤一由把国际语音学协会变换成丝兰属植物蛋白质催化的 IAA 的一个限制率的步骤跟随的色氨酸 aminotransferases 把色氨酸变换成 indole-3-pyruvic 酸(国际语音学协会) 。我们识别了推出了氨基酸序列的基因分享的八通常认为的 StYUC (茄属 tuberosum 丝兰属植物) Arabidopsis 丝兰属植物蛋白质的有那些的 50%70% 身份。都包括正规、保存丝兰属植物序列:FATGY 主题, FMO 签名顺序和 NADP 有约束力的序列。另外,五基因与 ~ 被发现 50% 氨基酸顺序身份到 Arabidopsis 色氨酸 aminotransferases。转基因的土豆(茄属 tuberosum cv。Jowon ) 组成地, overexpressing Arabidopsis AtYUC6 显示了象狭窄的向下卷的叶子,增加的高度,直立的身高,和长寿那样的高植物生长素的显型。转基因的土豆植物 overexpressing AtYUC6 基于减少的水损失显示出提高的干旱忍耐。显型在叶子与反应的氧种类的减少的层次被相关。结果在可以被利用改变植物回答到环境的土豆建议植物生长素生合成的一条功能的丝兰属植物小径。 | Jeong Im Kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-Yung Cha Woe-Yeon Kim Min Chul Kim Woo Sik Chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-Woo Lee Dae-Jin Yun | 2013 | Molecular Plant2013，6，2： | 15 |
| 19 | 果胶酶对苹果渣中多酚类物质的提取效果研究显示文摘具有多种生理活性的多酚类物质在苹果渣中主要以聚合体的形态存在。本研究利用果胶酶分解果胶质,把聚合态的多酚类物质转变为游离态,并提高多酚类物质的提取率。实验得出果胶酶释放总多酚类物质的最佳反应条件是温度为37℃,pH为3.6,酶/基质比例为12%,反应时间为11h。在此条件下,总多酚类物质(total phenolic compounds,TPC)和总黄酮类物质(total flavonoid compounds,TFC)含量分别达到9.08g/kg和1.38g/kg,比对照组的7.05g/kg和0.91g/kg分别提高1.3倍和1.5倍。果胶酶处理组比对照组多检出咖啡酸、香豆酸、阿魏酸、根皮素和未知物U3。以上结果表明,果胶酶具有较强的分解果胶质的功能,并能提高总多酚类物质的含量。 | 郑虎哲 Hye-Ryun Lee Sang-Han Lee Chang-Seob Kim Shin-Kyo Chung | 2008 | 分析化学2008，36，3： | 13 |
| 20 | Efforts to increase image quality during endoscopy:The role of pronase显示文摘Clear visualization of the gastrointestinal mucosal surface is essential for thorough endoscopy. An unobstructed assessment can reduce the need for additional timeconsuming manipulations such as frequent washing and suction,which tend to prolong total procedure time. However,mucus,foam,and bubbles often hinder clear visibility during endoscopy. Premedication with pronase,a compound of mixed proteolytic enzymes,has been studied in order to improve mucosal visibility during endoscopy. Although its effects differ according to the location in the stomach,premedication with pronase 10 to 20 min before endoscopy significantly improves mucosal visibility without affecting the accuracy of Helicobacter pylori identification. The effects of pronase as premedication also extend to chromoendoscopy,narrow-band imaging,magnifying endoscopy,and endoscopic ultrasonography. In addition,endoscopic flushing with pronase during endoscopy may improve the quantity and the quality of a biopsy to some degree. Although improved mucosal visibility does not necessarily improve clinical outcomes,premedication with pronase may be helpful for increasing the detection rate of early cancers. | Gwang Ha Kim Yu Kyung Cho Jae Myung Cha Sun-Young Lee Il-Kwun Chung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，5： | 13 |
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