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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Analyses of trends and causes for variations in runoff and sediment load of the Yellow River显示文摘Due to the impacts of globe climate change and human activities,dramatic variations in runoff and sediment load were observed for the Yellow River.Analyses of nearly 65 years' data measured at main hydrologic-stations on the Yellow River from 1950 to 2014 indicated that,except for the Tangnaihai station in the head region,sharp downward trends existed in both the annual runoff and annual sediment load according to the Mann-Kendal trend test;and their abrupt changes occurred in 1986 and in1980,respectively,according to the rank sum test.Factors affecting the changes in the runoff and sediment load were very complicated.Results indicated that the reducing precipitation and the increasing water consumption were the main causes for the runoff decline,while the impoundment of the Longyangxia Reservoir and its combined operation with the Liujiaxia Reservoir exerted a direct bearing on the abrupt change in the annual runoff.In addition to the sediment load decrease associated with the runoff reduction,the reduced storm intensity,the conducted soil erosion control,and the constructed dam buildings all played an important role in the trends and abrupt changes of sediment load decline. | Hongling Shi Chunhong Hu Yangui Wang Cheng Liu Huimei Li | 2017 | International Journal of Sediment Research2017，32，2： | 11 |
| 3 | Shrinking of Dongting Lake and its weakening connection with the Yangtze River:Analysis of the impact on flooding显示文摘In this article,the shrinking of Dongting Lake and its progressively weakening connection with the Yangtze River and their impact on flooding before and after the implementation of the Three Gorges Project are analyzed.In recent decades,human activity combined with natural processes has altered the flow of the middle reach channel of the Yangtze River and interfered with its connection with Dongting Lake.This has resulted in progressively more frequent flooding in the area.This study uses hydrological data to analyze the annual maximum discharge and annual maximum stage development of the middle reach of the Yangtze River and Dongting Lake.In recent decades before the Three Gorges Project became operational in 2003,the annual maximum discharge and the maximum stage recorded in the middle reach of the river downstream of Dongting Lake had increased,a result of the weakening of the flood regulation function of Dongting Lake;the annual maximum stage at Luoshan station(downstream,close to the confluence of the Yangtze River and Dongting Lake) had risen by about 2.0 m during 1955-2005,(1.5 m attributed to annual maximum discharge and 0.5 m to river channel deposition).Observational data recorded after the Three Gorges Project was put into operation in 2003,it can be seen that deposition in the Dongting Lake has nearly ceased and the lake's connection with the Yangtze River is stable.It is evident that the flood regulation function of Dongting Lake will continue,and that during the lifetime of the Three Gorges Project,the flood situation in the middle reach of the Yangtze River and Dongting Lake will remain stable. | Chunhong Hu Chunming Fang Wenhong Cao | 2015 | International Journal of Sediment Research2015，30，3： | 9 |
| 4 | Effect of suspended sediment grain size on channel sedimentation in the lower Yellow River and some implications显示文摘Based on the data of suspended sediment transport and channel sedimentation in various grain size fractions in the period of 1962―1985, the relationship between channel sedimentation in the lower Yellow River and sediment input has been plotted with respect to each grain size fraction. Several fill-scour thresholds in sediment input have been identified from these graphs. It was found that the fill-scour threshold in sediment input decreases with the increase in fraction grain size. The correlation coefficient between channel sedimentation and sediment input becomes larger with the increasing fraction grain size, indicating that channel sedimentation depends more on coarser grain size fractions than on smaller ones. The fraction channel sedimentation induced by unit change of fraction sediment input increases with grain size. Of the input of sediment larger than 0.025 mm, 43.73% was deposited on the channel, and for inputs of sediments larger than 0.05 mm and larger than 0.10 mm, 76.61% and 97.68% were deposited on the channel, respectively. Thus, for reduction of each ton of sediment larger than 0.10 mm from the drainage basin, the resultant reduction in channel sedimentation in the lower Yellow River would be 1.275 times that for the sediment larger than 0.10 mm, and 2.234 times that for the sediment larger than 0.025 mm. Therefore, if the erosion and sediment control measures are enforced in the areas where >0.05 or >0.10 mm sediment is produced, then the best beneficial will be achieved in reducing sedimentation in the lower Yellow River. | XU JiongXin HU ChunHong CHEN JianGuo | 2009 | Science China(Technological Sciences)2009，52，8： | 9 |
| 5 | Strategies for managing reservoir sedimentation显示文摘Sediment deposition in reservoirs has caused the loss of 66% of the reservoir capacity in China. The main sedimentation control strategies are: 1) storing the clear water and releasing the turbid water; 2) releasing turbidity currents; 3) Draw-down flushing and empty flushing; and 4) dredging. The paper summarizes these strategies with examples. Sediment transport in many Chinese rivers occurs mostly during the 2-4 month flood season, that is, 80-90% of the annual sediment load is transported with 50-60% of the annual runoff. By storing the clear water after the flood season and releasing the turbid water during the flood season, less sediment deposits in the reservoir while the reservoir is still able to store enough water for power generation in the low flow season. The Three Gorges and Sanmenxia reservoirs apply this strategy and control sedimentation effectively. Turbidity currents have become the main sedimentation control strategy for the Xiaolangdi Reservoir. Empty flushing involves reservoir draw-down to temporarily establish riverine flow along the impound reach, flushing the eroded sediment through the outlets. Case studies with the Hengshan Reservoir and Zhuwo Reservoir are presented. Jet dredgers have been used to agitate the reservoir deposit so that the deposit is released from the reservoir with currents. The sediment releasing efficiency is 30-100% for storing the clear and releasing the turbid; 6-40 % for turbidity current; and 2,400-5,500% for empty flushing. Empty flushing causes high ecological stress on the ecosystem to the downstream reaches. Storing the clear and releasing the turbid is the best strategy to control reservoir sedimentation while achieving hydro-power benefit and maintain ecological stability. | Zhao-yin WANG Chunhong HU | 2009 | International Journal of Sediment Research2009，24，4： | 8 |
| 6 | White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness显示文摘In this study, we aimed to(1) identify white matter(WM) deficits underlying the consciousness level in patients with disorders of consciousness(DOCs) using diffusion tensor imaging(DTI), and(2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest(ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients. | Xuehai Wu Jiaying Zhang Zaixu Cui Weijun Tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong Ying Mao Yong He | 2018 | Neuroscience Bulletin2018，34，4： | 8 |
| 7 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 8 | Sediment delivery ratio and its uncertainties on flood event scale:Quantification for the Lower Yellow River显示文摘Sediment delivery ratio(SDR)for fluvial rivers was formulated with sediment rating curve.The observed data of SDR on flood event scale of the Lower Yellow River(LYR)were adopted to examine the formulation and to calibrate the model parameters.A regression formula of SDR was then established and its 95%prediction interval was accordingly quantified to represent its overall uncertainties.Three types of factors including diversity of the incoming flow conditions,river self-regulation processes,and human activities were ascribed to the uncertainties.The following were shown:(1)With the incoming sediment coefficient(ISC)being a variable,it was not necessary to adopt the incoming flow discharge as the second variable in the formulation of SDR;and(2)ISC=0.003 and therefore SDR=2 might be a threshold for distinguishing the characteristics of sediment transport within the LYR.These findings would highlight sediment transport characteristics on the scale of flood event and contribute to uncertainty based analysis of water volume required for sediment transport and channel maintenance of the LYR. | FU XuDong 1,JIANG LiWei 1,WU BaoSheng 1,HU ChunHong 2,WANG GuangQian 1 &FEI XiangJun 1 1State Key Laboratory of Hydroscience and Engineering,Tsinghua University,Beijing 100084,China 2China Institute of Hydropower and Water Resources Research,Beijing 100044,China | 2010 | Science China(Technological Sciences)2010，53，3： | 7 |
| 9 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 10 | Three-dimensional multi-phase simulation of the mixing and segregation of binary particle mixtures in a two-jet spout fluidized bed显示文摘This study presents a three-dimensional numerical study of the mixing and segregation of binary particle mixtures in a two-jet spout fluidized bed based on an Eulerian-Eulerian three-fluid model.Initially,the particle mixtures were premixed and packed in a rectangular fluidized bed.As the calculation began,the gas stream was injected into the bed from the distributor and jet nozzles.The model was validated by comparing the simulated jet penetration depths with corresponding experimental data.The main features of the complex gas-solid flow behaviors and the mechanism of mixing and segregation of the binary mixtures were analyzed.Moreover,further simulations were carried out to evaluate the effects of operating conditions on the mixing and segregation of binary particle mixtures.The results illustrate that mixing can be enhanced by increasing the jet velocity or enlarging the difference of initial proportions of binary particle mixtures. | Xiaojia Wang Baosheng Jin Yanyan Wang Chunhong Hu | 2015 | Particuology2015，13，5： | 6 |
| 11 | Modeling sediment transport in the lower Yellow River and dynamic equilibrium threshold value显示文摘A major problem in the lower Yellow River is the insufficient incoming water and excessive sediment supply, which results in serious deposition, continuous rise of the river bed, and austere flood control situation. To understand the sediment transport regularity of the lower Yellow River and determine the relationship between sedimentation, incoming water and sediment, and zone water diversion, a mathematical model of the sediment suitable for the characteristics of the lower Yellow River has been developed. This model is first rated and verified by large quantity of observed data, and it is then used to analyze silting reduction for the lower Yellow River by Xiaolangdi Reservoir’s operation, the relationship between zone water diversion and channel sedimentation, and critical equilibrium of sedimentation in the lower Yellow River. The threshold values of equilibrium of sedimentation in the lower Yellow River are estimated and they suggest that deposition in the lower Yellow River can be effectively reduced by the operation of regulating flow and sediment from Xiaolangdi Reservoir, water-soil conservation, and controlling water diversion along the lower Yellow River. | HU Chunhong GUO Qingchao | 2004 | Science China(Technological Sciences)2004，47，z1： | 6 |
| 12 | Knowledge Graph Embedding for Hyper-Relational Data显示文摘Knowledge graph representation has been a long standing goal of artificial intelligence. In this paper,we consider a method for knowledge graph embedding of hyper-relational data, which are commonly found in knowledge graphs. Previous models such as Trans(E, H, R) and CTrans R are either insufficient for embedding hyper-relational data or focus on projecting an entity into multiple embeddings, which might not be effective for generalization nor accurately reflect real knowledge. To overcome these issues, we propose the novel model Trans HR, which transforms the hyper-relations in a pair of entities into an individual vector, serving as a translation between them. We experimentally evaluate our model on two typical tasks—link prediction and triple classification.The results demonstrate that Trans HR significantly outperforms Trans(E, H, R) and CTrans R, especially for hyperrelational data. | Chunhong Zhang Miao Zhou Xiao Han Zheng Hu Yang Ji | 2017 | Tsinghua Science and Technology2017，22，2： | 5 |
| 13 | DYNAMIC CHARACTERISTICS OF SEA CURRENTS AND SEDIMENT DISPERSION IN THE YELLOW RIVER ESTUARY显示文摘DYNAMICCHARACTERISTICSOFSEACURRENTSANDSEDIMENTDISPERSIONINTHEYELLOWRIVERESTUARYHUChunhong1,JIZuwen2andWANGTao3ABSTRACTDynamic... | Hu, Chunhong Ji, Zuwen Wang, Tao | 1998 | International Journal of Sediment Research1998，13，2： | 5 |
| 14 | Information extraction and CT reconstruction of liver images based on diffraction enhanced imaging显示文摘X-ray phase-contrast imaging (PCI) is a new emerging imaging technique that generates a high spatial resolution and high contrast of biological soft tissues compared to conventional radiography. Herein a biomedical application of diffraction enhanced imaging (DEI) is presented. As one of the PCI methods, DEI derives contrast from many different kinds of sample information, such as the sample’s X-ray absorption, refraction gradient and ultra-small-angle X-ray scattering (USAXS) properties, and the sample information is expressed by three parametric images. Combinedwith computed tomography (CT), DEI-CT can produce 3D volumetric images of the sample and can be used for investigating micro-structures of biomedical samples. Our DEI experiments for liver samples were implemented at the topography station of Beijing Synchrotron Radiation Facility (BSRF). The results show that by using our provided information extraction method and DEI-CT reconstruction approach, the obtained parametric images clearly display the inner structures of liver tissues and the morphology of blood vessels. Furthermore, the reconstructed 3D view of the liver blood vessels exhibits the micro blood vessels whose minimum diameter is on the order of about tens of microns, much better than its conventional CT reconstruction at a millimeter resolution. In conclusion, both the information extraction method and DEI-CT have the potential for use in biomedical micro-structures analysis. | Chunhong Hu Tao Zhao Lu Zhang Hui Li Xinyan Zhao Shuqian Luo | 2009 | Progress in Natural Science:Materials International2009，19，8： | 5 |
| 15 | Anti-aggregation dispersion of ultrafine particles by electrostatic technique显示文摘The dispersion of ultrafine particles in the air can be achieved by mechanical method or surface modification. In this work, the electrostatic technique was first employed for anti-aggregation of ultrafine particles. When the relative humidity of the air is within the region of 70%-75%, effective storage time of ultrafine particles can reach 72 h after treatment by the electrostatic technique. The experimental results showed that this technique imparted ultrafine particles much more pronounced anti-aggregation property. In the dry air, the critical diameter of ultrafine particles anti-aggregated by the electrostatic technique is the function of particle property and charging field intensity. The critical diameter is inversely proportional to the square of the charging field intensity. | REN Jun LU Shouci SHEN Jian YU Chunhong HU Boxing | 2001 | Chinese Science Bulletin2001，46，9： | 3 |
| 16 | A GPU-based numerical model coupling hydrodynamical and morphological processes显示文摘Sediment transport simulations are important in practical engineering.In this study,a graphics processing unit(GPU)-based numerical model coupling hydrodynamical and morphological processes was developed to simulate water flow,sediment transport,and morphological changes.Aiming at accurately predicting the sediment transport and sediment scouring processes,the model resolved the realistic features of sediment transport and used a GPU-based parallel computing technique to the accelerate calculation.This model was created in the framework of a Godunov-type finite volume scheme to solve the shallow water equations(SWEs).The SWEs were discretized into algebraic equations by the finite volume method.The fluxes of mass and momentum were computed by the Harten,Lax,and van Leer Contact(HLLC) approximate Riemann solver,and the friction source terms were calculated by the proposed a splitting point-implicit method.These values were evaluated using a novel 2 D edge-based MUSCL scheme.The code was programmed using C++and CUDA,which could run on GPUs to substantially accelerate the computation.The aim of the work was to develop a GPU-based numerical model to simulate hydrodynamical and morphological processes.The novelty is the application of the GPU techniques in the numerical model,making it possible to simulate the sediment transport and bed evolution in a high-resolution but efficient manner.The model was applied to two cases to evaluate bed evolution and the effects of the morphological changes on the flood patterns with high resolution.This indicated that the GPU-based high-resolution hydro-geomorphological model was capable of reproducing morphological processes.The computational times for this test case on the GPU and CPU were298.1 and 4531.2 s,respectively,indicating that the GPU could accelerate the computation 15.2 times.Compared with the traditional CPU high-grid resolution,the proposed GPU-based high-resolution numerical model improved the reconstruction speed more than 2.0-12.83 times for different grid resolutions while remaining computationally efficient. | Jingming Hou Yongde Kang Chunhong Hu Yu Tong Baozhu Pan Junqiang Xia | 2020 | International Journal of Sediment Research2020，35，4： | 3 |
| 17 | Vertical concentration profile of nonuniform sediment显示文摘A new formula for the concentration profile of nonuniform sediment is derived using the diffusion differential equation with equilibrium bed concentration.The interaction coefficient for nonuniform sediment particles as a function of both relative diameter and geometric standard deviation of nonuniform sediment is taken into account in the settling velocity.The diffusion coefficient is obtained from the logarithmic velocity profile.This new formula possesses several advantages as follows:(1)avoids theoretical defect of the Rouse formula,which states that the sediment concentration is infinite at the bottom and zero at the water surface.(2)suitable for an arbitrary fraction of nonuniform sediment,and(3)easy to apply with a simple form.The formula yields less difference among concentration profiles for various particles than that for uniform sediment and reveals the lawfor fractional concentration distribution of nonuniform sediment.The calculated concentration agrees well with the measured data from the Yangtze River. | Zhilin Sun Haolei Zheng Dan Xu Chunhong Hu Chaofan Zhang | 2021 | International Journal of Sediment Research2021，36，1： | 2 |
| 18 | CUL4B facilitates HBV replication by promoting HBx stabilization显示文摘Objective:Hepatitis B virus(HBV)infection is a major public health problem worldwide.However,the regulatory mechanisms underlying HBV replication remain unclear.Cullin 4 B-RING ubiquitin E3 ligase(CRL4 B)is involved in regulating diverse physiological and pathophysiological processes.In our study,we aimed to explain the role of CUL4 B in HBV infection.Methods:Cul4 b transgenic mice or conditional knockout mice,as well as liver cell lines with CUL4 B overexpression or knockdown,were used to assess the role of CUL4 B in HBV replication.Immunoprecipitation assays and immunofluorescence staining were performed to study the interaction between CUL4 B and HBx.Cycloheximide chase assays and in vivo ubiquitination assays were performed to evaluate the half-life and the ubiquitination status of HBx.Results:The hydrodynamics-based hepatitis B model in Cul4 b transgenic or conditional knockout mice indicated that CUL4 B promoted HBV replication(P<0.05).Moreover,the overexpression or knockdown system in human liver cell lines validated that CUL4 B increased HBV replication in an HBx-dependent manner.Importantly,immunoprecipitation assays and immunofluorescence staining showed an interaction between CUL4 B and HBx.Furthermore,CUL4 B upregulated HBx protein levels by inhibiting HBx ubiquitination and proteasomal degradation(P<0.05).Finally,a positive correlation between CUL4 B expression and HBV pg RNA level was observed in liver tissues from HBV-positive patients and HBV transgenic mice.Conclusions:CUL4 B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation.CUL4 B may therefore be a potential target for anti-HBV therapy. | Haixia Shan Bo Wang Xiaodong Zhang Hui Song Xi Li Yongxin Zou Baichun Jiang Huili Hu Hao Dou Changshun Shao Lifen Gao Chunhong Ma Xiaoyun Yang Xiaohong Liang Yaoqin Gong | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 19 | The influence of the metal net charge of non-metallocene early transition metal catalyst on the ethylene polymerization activity显示文摘The net charges on central metals of a serial non-metallocene early transition metal catalysts (FI catalyst) with similar steric hindrance were caculated with MM-QEq (molecular mechmism-charge equilibration) method and associated with ethylene polymerization activities of these FI catalyts. It was found that the activity increased with the net charge on metal if ignoring the influence of the steric hindrance. In other words, introduction of strong and/or more electron-withdrawing groups onto the ligand of FI catalyst would enhance the activity of the catalyst. This conculsion gave a direction to designing new FI catalyst with higher activity. | WU ChunHong LI HuaYi FENG YuQi HU YouLiang | 2008 | Chinese Science Bulletin2008，53，20： | 1 |
| 20 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
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