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| 1 | Energy Metabolism Disorder and Myocardial Injury in Chronic Myocardial Ischemia with Qi Deficiency and Blood Stasis Syndrome Based on 2-DE Proteomics显示文摘目的将询问在由严峻的 twodimensional 电气泳动(2-DE ) 的长期的心肌的局部缺血的蛋白质印射探索可能的固有的病理学的机制和 qi 缺乏和血壅滞症候群的治疗学的干预的特征。方法 Ameroid 缩窄器戒指被放在左前面的下降冠的动脉的第一间隔上在中国缩小的猪上准备长期的心肌的局部缺血模型。动物随机分别地在每个组带着 10 个动物被划分成假冒的组和模型组。四个诊断信息的动态症状观察从 0 ~ 12 个星期被收集。Echocardiography 被采用评估心脏的功能和心肌的局部缺血, 2-DE 和飞行团 spectrometry (MALDI-TOF-MS ) 的帮助矩阵的激光 desorption/ionization-time 的度被用来在动物上执行 proteomics 研究。连接酶的 immunosorbent 试金被使用与 qi 缺乏和血壅滞症候群在长期的心肌的局部缺血上识别相关微分蛋白质。初步的学习在第 12 星期,有 qi 缺乏的长期的心肌的局部缺血和血壅滞症候群模型发现了那的结果稳定地被建立。与假冒的组相比,有 8 不同蛋白质下面调整, 22 蛋白质起来调整显著地。在由 MALDITOF-MS/MS 验证了以后, 11 个蛋白质点被识别。不同蛋白质主要与精力新陈代谢和心肌的结构的损害被联系,包括 isocitrate 脱氢酶 3 (NAD+) alpha , NADH 脱氢酶( NAD ) Fe-S 蛋白质 1 ,链 A (由有约束力的领域的 aldose reductase 的水晶结构揭示新 Nadph ),热吃惊蛋白质 27 ( HSP27 ), oxidoreductase (NAD有约束力的蛋白质),抗氧化剂蛋白质 isoform ,心脏的 troponin T ( cTnT ),肌浆球蛋白(肌浆球蛋白光多肽),心脏的 alpha tropomyosin , apolipoprotein A-I 和白朊。结论下面调整的精力新陈代谢混乱由 NADH 呼吸的链和心肌的损害调停了可以是有 qi 的心肌的局部缺血的致病缺乏和血壅滞症候群。这些蛋白质可以是为 qi 缺乏和血壅滞症候群的潜在的诊断标记。 | Yong Wang 王 勇 (11230) Wen-jing Chuo 啜文静 (11230) Chun Li 李 春 (11230) Shu-zhen Guo 郭淑贞 (11230) Jian-xin Chen 陈建新 (11230) Jun-da Yu 余俊达 (11230) Wei Wang 王 伟 (11230) | 2013 | Chinese Journal of Integrative Medicine2013，19，8： | 4 |
| 2 | EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis ingastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways显示文摘 | Xiao-Guang Lv Meng-Yao Ji Wei-Guo Dong Xiao-Fei Lei Meng Liu Xu-Feng Guo Jing Wang Chuo Fang | 2012 | Molecular Medicine Reports2012，，5： | 1 |
| 3 | Clinical Efficacy of the Integrated Medical Care Model Combined with Psychological Intervention in Tuberculosis Patients with Lung Cancer显示文摘Objective:To explore the clinical efficacy of the integrated medical care model combined with psychological intervention in pulmonary tuberculosis patients with lung cancer.Methods:From January to December 2022,60 pulmonary tuberculosis patients with lung cancer admitted to our hospital were selected as the research subjects.Using the random number table method,the patients were divided into two groups,a control group and a study group,with 30 cases in each group.The chest computed tomography(CT)examination results,mental state assessment(including depression scale and anxiety scale)scores,incidence of adverse reactions,treatment effect,and length of hospital stay were compared between the two groups.Results:The treatment effect of the patients in the study group was better than that of the patients in the control group(P<0.05);the duration of hospitalization,chest CT examination results,mental state assessment scores,and incidence of adverse reactions of the study group and the control group,were significantly different(P<0.05).Conclusion:The integrated medical care model combined with psychological intervention can effectively improve the treatment effect of pulmonary tuberculosis patients with lung cancer and prevent the occurrence of adverse reactions;thus,it should be promoted in clinical practice. | Wei Yuan Dandan Yang Xinyi Ye Zhangying Li Xing Luan Min Zheng Yanling Feng Mi Zhang Chuo Guo | 2023 | Journal of Clinical and Nursing Research2023，7，2： | 0 |
| 4 | Application Research of Detailed Nursing of Tuberculous Meningitis Patients显示文摘Objective:To explore the application effect of detailed nursing in tuberculous meningitis nursing.Methods:A total of 52 patients with tuberculous meningitis who were admitted to our hospital from May 2019 to February 2022 were selected as the research objects,and divided into 25 patients in the control group and 27 patients in the study group according to the random table method,and the compliance,quality of life,recurrence,nursing satisfaction,depression,anxiety and PSQI scores of the two groups were observed and analyzed.Results:In the study group,the number of patients with complete compliance,partial compliance and non-compliance were 13,11 and 3,respectively,and the compliance rate was 88.89%.In the control group,the number of patients with complete compliance,partial compliance and non-compliance were 11,5 and 9,respectively,and the compliance rate was 67.86%,and P<0.05 was considered statistically significant.The quality-of-life score of the control group was 48.36±2.24,which was lower than that of the study group,50.23±2.12,(P<0.05).The rate of recurrence of the control group was 36.00%,which was significantly higher than 7.41%in the study group(P<0.05).There was no significant statistical difference between the SAS,SDS,and PSQI scores of the two groups before nursing,(P>0.05).After nursing,both groups showed a decrease in SDS and SAS scores,with the study group showing significantly lower scores than the control group(P<0.001).Besides,the PSQI dimension scores and total score in the study group were lower than those in the control group(P<0.001).Moreover,the nursing satisfaction of the patients in the study group was significantly higher than that in the control group(93.02%>71.79%),(P<0.05).Conclusion:A full range of detailed care is not only helpful for accurate diagnosis and treatment of patients,but also helps to create a satisfactory hospital environment for patients.Results from this study showed that detailed nursing care for patients with tuberculous meningitis shows a significant positive effect and should be applied in clinical practices. | Wei Yuan Dandan Yang Zhangying Li Chuo Guo Xinyi Ye Min Zheng | 2022 | Journal of Clinical and Nursing Research2022，6，5： | 0 |
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