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| 1 | Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution:A prospective randomized double-blind study显示文摘AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study period.RESULTS: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P < 0.05). The median value of days in intensive care unit was also similar in both groups [6 ± 2 (5-8) d vs 6 ± 2 (5-7) d]. The median duration of EN was 8 ± 4 (6-12) d vs 10 ± 4 (6-13) d in the study and control groups, respectively (P > 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy. | Tarkan Karakan Meltem Ergun Ibrahim Dogan Mehmet Cindoruk Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，19： | 50 |
| 2 | Influence of H pylori on plasma ghrelin in patients without atrophic gastritis显示文摘AIM:To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic gastritis.METHODS:Fifty consecutive patients(24 males and 26 females)with either H pylori-positive gastritis(n = 34)or H pylori-negative gastritis(n = 16)with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this study.Thirty-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid,1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d,followed by an additional 4 wk of 30 mg lansoprazol treatment.H pylori infection was eradicated in 23 of 34(67.6%)patients.H pylori-positive patients were given eradication therapy.Gastric acidity was determined via intragastric pH catethers.Serum ghrelin was measured by radioimmunoassay(RIA).RESULTS:There was no signifficant difference in plasma ghrelin levels between H pylori-positive and H pylori-negative groups(81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L).In addition,there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication therapy.CONCLUSION:H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis. | Mehmet Cindoruk Ilhan Yetkin Serpil Muge Deger Tarkan Karakan Erdal Kan Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，10： | 13 |
| 3 | Is there an association between Helicobacter pylori in the inlet patch and globus sensation?显示文摘AIM:To determine the association between Helicobacter pylori(H.pylori)and globus sensation(GS)in the patients with cervical inlet patch. METHODS:Sixty-eight patients with esophageal inlet patches were identified from 6760 consecutive patients undergoing upper gastrointestinal endoscopy prospectively.In these 68 patients with cervical inlet patches, symptoms of globus sensation(lump in the throat), hoarseness,sore throat,frequent clearing of the throat,cough,dysphagia,odynophagia of at least 3 mo duration was questioned prior to endoscopy. RESULTS:Cervical heterotopic gastric mucosa(CHGM) was found in 68 of 6760 patients.The endoscopic prevalence of CHGM was determined to be 1%.H.pylori was identified in 16(23.5%)of 68 patients with inlet patch.53 patients were classified as CHGMⅡ.This group included 48 patients with globus sensation,4 patients with chronic cough and 1 patient with hoarseness.All the patients who were H.pylori(+)in cervical inlet patches had globus sensation.CONCLUSION:Often patients with CHGM have a long history of troublesome throat symptoms.We speculate that disturbances in globus sensation are like non-ulcer dyspepsia. | Hakan Alagozlu Zahide Simsek Selahattin Unal Mehmet Cindoruk Sukru Dumlu Ayse Dursun | 2010 | World Journal of Gastroenterology2010，16，1： | 8 |
| 4 | Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases显示文摘 | Mehmet Cindoruk Meltem Yalinay Cirak Selahattin Unal Tarkan Karakan Gulbanu Erkan Doruk Engin Sukru Dumlu Sevgi Turet | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 2 |
| 5 | Concentration and gas/particle partitioning of polychlorinated biphenyls (PCBs) at an industrial site at Bursa, Turkey 显示文摘 | Cindoruk S S Esen F Tasdemir Y | 2007 | Atmospheric Research2007，85，34： | 1 |
| 6 | Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases显示文摘 | CINDORUK M CIRAK MY UNAL S | 2008 | Eur J Gastroenteml Hepatol2008，20，1： | 1 |
| 7 | Hepatic steatosis has no impact on the outcome of treatment in patients with chronic hepatitis B infection显示文摘 | Cindoruk M Karakan T Unal S | | 0，，： | 1 |
| 8 | Concentration and gas/particle partitioning of polychlorinated biphenyls(PCBs) at an industrial site at Bursa, Turkey 显示文摘 | CINDORUK S S ESEN F TASDEMIR Y | 2007 | Atmos Res2007，85，34： | 1 |
| 9 | Characterization of gas/particle concentrations and partitioning of polychlorinated biphenyls (PCBs) measured in an urban site of Turkey显示文摘 | Cindoruk S S Tasdemir Y | 2007 | Environmental Pollution2007，148，1： | 1 |
| 10 | EUS versus endoscopic retrograde cholangiography for patients with intermediate probabili- ty of bile duct stones: a prospective randomized trial 显示文摘 | Karakan T Cindoruk M Alagozlu H | 2009 | Gastroin- test Endosc2009，69，2： | 1 |
| 11 | Dynamics of atmospheric polychlorinated biphenyls(PCBs):concentrations,patterns,partitioning and dry deposition level estimations in a residential site of Turkey显示文摘 | Cindoruk S S Tasdemir Y | 2010 | Environmental Monitoring Assessment2010，162，14： | 1 |
| 12 | Efficacy and safety ofSaccharomyces boulardii in the 14-day triple anti-Helicobacter pyloritherapy:a prospective randomized placebo-controlled double-blindstudy显示文摘 | CINDORUK M ERKAN G KARAKAN T | 2007 | Helicobacter2007，12，4： | 1 |
| 13 | Severe INR elevation in a patient with choledocholithiasis receiving cefoperazone 显示文摘 | Alagozlu H Cindoruk M Unal S | 2006 | Clin Drug Investig2006，26，8： | 1 |
| 14 | Hepatic steatosis has no impact on the outcome of treatment in patients with chronic hepatitis B in- fection显示文摘 | Cindoruk M Karakan T Unal S | 2007 | J Clin Gastroenterol2007，41，5： | 1 |
| 15 | PPARalpha agonist treatment increases trefoil factor family-3 expression and attenuates apoptosis in the liver tissue of bile duct-ligated rats显示文摘 | KARAKAN T KEREM M CINDORUK M | 2013 | Turk J Gastroenterol2013，24，2： | 1 |
| 16 | Severe INR elevation in a patient with choledocholithiasis receiving cefoperazone 显示文摘 | Alagozlu H Cindoruk M Unal S | 2006 | Clin Drug Investig2006，26，8： | 1 |
| 17 | Hepatic steatosish has no im- pact on the outcome of treatment in patients with chronic hepatitis B infection显示文摘 | Cindoruk M Karakan T Unal S | 2007 | J Clin Gastroenterol2007，41，： | 1 |
| 18 | Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases显示文摘 | Mehmet Cindoruk Meltem Yalinay Cirak Selahattin Unal Tarkan Karakan Gulbanu Erkan Doruk Engin Sukru Dumlu Sevgi Turet | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 1 |
| 19 | Increased Colonic Intraepithelial Lymphocytes in Patients With Hashimoto’s Thyroiditis显示文摘 | Mehmet Cindoruk Candan Tuncer Ay?e Dursun Ilhan Yetkin Taner Karakan Nuri ?akir Irfan Soykan | 2002 | Journal of Clinical Gastroenterology2002，，3： | 1 |
| 20 | Characterization of gas/particle concentrations and partitioning of polychlorinated biphenyls (PCBs) measured in an urban site of Turkey 显示文摘 | Cindoruk S S Tasdemir Y | 2007 | Environmental Pollution2007，148，1： | 1 |
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