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| 1 | Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution:A prospective randomized double-blind study显示文摘AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study period.RESULTS: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P < 0.05). The median value of days in intensive care unit was also similar in both groups [6 ± 2 (5-8) d vs 6 ± 2 (5-7) d]. The median duration of EN was 8 ± 4 (6-12) d vs 10 ± 4 (6-13) d in the study and control groups, respectively (P > 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy. | Tarkan Karakan Meltem Ergun Ibrahim Dogan Mehmet Cindoruk Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，19： | 50 |
| 2 | Influence of H pylori on plasma ghrelin in patients without atrophic gastritis显示文摘AIM:To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic gastritis.METHODS:Fifty consecutive patients(24 males and 26 females)with either H pylori-positive gastritis(n = 34)or H pylori-negative gastritis(n = 16)with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this study.Thirty-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid,1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d,followed by an additional 4 wk of 30 mg lansoprazol treatment.H pylori infection was eradicated in 23 of 34(67.6%)patients.H pylori-positive patients were given eradication therapy.Gastric acidity was determined via intragastric pH catethers.Serum ghrelin was measured by radioimmunoassay(RIA).RESULTS:There was no signifficant difference in plasma ghrelin levels between H pylori-positive and H pylori-negative groups(81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L).In addition,there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication therapy.CONCLUSION:H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis. | Mehmet Cindoruk Ilhan Yetkin Serpil Muge Deger Tarkan Karakan Erdal Kan Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，10： | 13 |
| 3 | Comparison of double balloon enteroscopy in adults and children显示文摘AIM: To compare results of double balloon enteroscopy (DBE) procedures in pediatric and adult patients. METHODS: The medical files of patients who underwent DBE at Gazi University School of Medicine, Ankara, Turkey between 2009 and 2011 were examined retrospectively. Adult and pediatric patients were compared according to DBE indications, procedure duration, final diagnosis, and complications. DBE procedures were performed in an operating room under general anesthesia by two endoscopists. An oral or anal approach was preferred according to estimated lesion sites. Overnight fasting of at least 6 h prior to the start of the procedure was adequate for preprocedural preparation of oral DBE procedures. Bowel cleansing was performed by oral administration of sennosides A and B solution, 2 mL/kg, and anal saline laxative en-ema. The patients were followed up for 2 h after the procedure in terms of possible complications. RESULTS: DBE was performed in 35 patients (5 pediatric and 30 adult). DBE procedures were performed for abdominal pain, chronic diarrhea, bleeding, chronic vomiting, anemia, and postoperative evaluation of anastomosis. Final diagnosis was diffuse gastric angiodysplasia (n = 1); diffuse jejunal angiodysplasia (n = 1); ulceration in the bulbus (n = 1); celiac disease (n = 1); low differentiated metastatic carcinoma (n = 1); PeutzJeghers syndrome (n = 1); adenomatous polyp (n = 1) and stricture formation in anastomosis line (n = 1). During postprocedural follow-up, abdominal pain and elevated amylase levels were noted in three patients and one patient developed abdominal perforation. CONCLUSION: With the help of technological improvements, we may use enteroscopy as a safe modality more frequently in younger and smaller children. | Odul Egritas Gurkan Tarkan Karakan Ibrahim Dogan Buket Dalgic Selahattin Unal | 2013 | World Journal of Gastroenterology2013，19，29： | 11 |
| 4 | Coexistence of Mirizzi syndrome with adenomyomatosis in the gallbladder:report of a case显示文摘BACKGROUND:Mirizzi syndrome is a rare complication of cholelithiasis. Adenomyomatosis is a common tumor-like lesion of the gallbladder. METHODS:A 52-year-old man was admitted to our hospital complaining of right hypochondriac pain and jaundice. Ultrasonography and computed tomography revealed stones in the gallbladder and dilation of the intrahepatic bile ducts. Magnetic resonance cholangiopancreatography revealed narrowing of the common bile duct caused by compression of the gallbladder. Laparotomy revealed type Ⅱ Mirizzi syndrome. RESULTS:Partial cholecystectomy with a Roux-en-Y hepaticojejunostomy reconstruction was performed. Histologically,Rokitansky-Aschoff sinus proliferation,hypertrophy of smooth muscles,and fibrosis were seen in the gallbladder. A segmental type of adenomyomatosis of the gallbladder was diagnosed. CONCLUSIONS:The pathogenic link between the two peculiar entities is unclear. A possible explanation is considered that the pathogenesis of Mirizzi syndrome is resulted from chronic inflammation due to adenomyomatosis. | Abdulkadir Bedirli Mustafa Kerem Hasan Bostanci Tarkan Karakan T. Tolga Sahin Nalan Akyurek | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，4： | 10 |
| 5 | Current endoscopic approach to indeterminate biliary strictures显示文摘Biliary strictures are considered indeterminate when basic work-up, including transabdominal imaging and endoscopic retrograde cholangiopancreatography with routine cytologic brushing, are non-diagnostic. Indeterminate biliary strictures can easily be mischaracterized which may dramatically affect patient's outcome. Early and accurate diagnosis of malignancy impacts not only a patient's candidacy for surgery, but also potential timely targeted chemotherapies. A significant portion of patients with indeterminate biliary strictures have benign disease and accurate diagnosis is, thus, paramount to avoid unnecessary surgery. Current sampling strategies have suboptimal accuracy for the diagnosis of malignancy. Emerging data on other diagnostic modalities, such as ancillary cytology techniques, single operator cholangioscopy, and endoscopic ultrasonography-guided fine needle aspiration, revealed promising results with much improved sensitivity. | David W Victor Stuart Sherman Tarkan Karakan Mouen A Khashab | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 6 | Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases显示文摘 | Mehmet Cindoruk Meltem Yalinay Cirak Selahattin Unal Tarkan Karakan Gulbanu Erkan Doruk Engin Sukru Dumlu Sevgi Turet | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 2 |
| 7 | Metabolic syndrome is related to long-term graft function in renal transplant recipients显示文摘 | Ozdemir FN Karakan S Akgul A | 2009 | Transplant Proc2009，41，7： | 1 |
| 8 | Effect of Post-Oxidizing on Tribological and Corrosion Behaviour of Plasma Nitrided AISI 5140 Steel显示文摘 | Akgun Alsaran Hikmet Altun Mehmet Karakan | 2004 | Surface and Coatings Technology2004，176，： | 1 |
| 9 | Hepatic steatosis has no impact on the outcome of treatment in patients with chronic hepatitis B infection显示文摘 | Cindoruk M Karakan T Unal S | | 0，，： | 1 |
| 10 | Factors related to fatigue and subgroups of fatigue in patients with end-stage renal disease显示文摘 | Karakan S Sezer S Ozdemir FN | 2011 | Clin Nephrol2011，76，5： | 1 |
| 11 | Risk factors for kidney impairment and differential impact of liver transplantation on renal function显示文摘 | Sezer S Karakan S Erismis B | 2011 | Minerva Transplant Proc2011，43，2： | 1 |
| 12 | Factors related to fatigue and subgroups of fatigue in patients with end-stage renal dis- ease 显示文摘 | Karakan S Sezer S Ozdemir FN | 2011 | Clin Nephro12011，76，5： | 1 |
| 13 | Prevalence of IgA-antiendomysial antibody in a patient cohort with idiopathic low bone mineral density显示文摘AIM:To investigate the frequency of serum IgA-antiendomysial antibody positivity in patients with low bone mineral density and to assess the risk group for screening of celiac disease. METHODS:One hundred and thirty-five patients (14 male,121 female) with idiopathic low bone mineral density were evaluated. The median age was 57.2 years (24-81). Antiendomysial antibody was determined by the immunofluorescence method using a commercial kit (INOVA Diagnostics Inc.,CA,USA),which employs a 5 μm thin cryostat section of monkey esophagus as a substrate. RESULTS:Of the 135 patients evaluated,13 were found to have positive IgA antiendomysial antibody test (9.6%) response. None of the patients had IgA deficiency. Endoscopic appearance and histological examination were normal in all of these patients. Seropositive patients had significantly lower age (48.9 ± 4.3 vs 59.2 ± 6.2,P < 0.05),higher ratio of male gender (61.5% vs 4.9%,P < 0.01) and pre-menopausal status (8.7% vs 1.3%,P < 0.01). Lumbar spine and femoral neck z-scores,but not t-scores were significantly lower in seropositive patients. Seropositive patients had lower serum 25 (OH) vitamin D,calcium and higher serum parathormone levels than seronegative patients. CONCLUSION:The screening of celiac disease in idiopathic osteoporosis should be restricted to patients without classical risk factors (younger,pre-menopausal,male gender) for osteoporosis. Bone mineral density measurements using z-scores should be considered for identifying risk groups for celiac disease. | T Karakan O Ozyemisci-Taskiran Z Gunendi F Atalay C Tuncer | 2007 | World Journal of Gastroenterology2007，13，21： | 1 |
| 14 | EUS versus endoscopic retrograde cholangiography for patients with intermediate probabili- ty of bile duct stones: a prospective randomized trial 显示文摘 | Karakan T Cindoruk M Alagozlu H | 2009 | Gastroin- test Endosc2009，69，2： | 1 |
| 15 | Factors related to fa- tigue and subgroups of fatigue in patients with end-stage renal disease显示文摘 | KARAKAN S SEZER S OZDEMIR FN | 2011 | Clin Nephrol2011，76，5： | 1 |
| 16 | Efficacy and safety ofSaccharomyces boulardii in the 14-day triple anti-Helicobacter pyloritherapy:a prospective randomized placebo-controlled double-blindstudy显示文摘 | CINDORUK M ERKAN G KARAKAN T | 2007 | Helicobacter2007，12，4： | 1 |
| 17 | Hepatic steatosis has no impact on the outcome of treatment in patients with chronic hepatitis B in- fection显示文摘 | Cindoruk M Karakan T Unal S | 2007 | J Clin Gastroenterol2007，41，5： | 1 |
| 18 | PPARalpha agonist treatment increases trefoil factor family-3 expression and attenuates apoptosis in the liver tissue of bile duct-ligated rats显示文摘 | KARAKAN T KEREM M CINDORUK M | 2013 | Turk J Gastroenterol2013，24，2： | 1 |
| 19 | Hepatic steatosish has no im- pact on the outcome of treatment in patients with chronic hepatitis B infection显示文摘 | Cindoruk M Karakan T Unal S | 2007 | J Clin Gastroenterol2007，41，： | 1 |
| 20 | Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases显示文摘 | Mehmet Cindoruk Meltem Yalinay Cirak Selahattin Unal Tarkan Karakan Gulbanu Erkan Doruk Engin Sukru Dumlu Sevgi Turet | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 1 |
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