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| 1 | Neuroendocrine and squamous colonic composite carcinoma:Case report with molecular analysis显示文摘Composite colorectal carcinomas are rare. There are amodest number of cases in the medical literature,with even fewer cases describing composite carcinoma with neuroendocrine and squamous components. There areto our knowledge no reports of composite carcinomamolecular alterations. We present a case of composite carcinoma of the splenic flexure in a 33 year-old Cau-casian male to investigate the presence and prognos-tic significance of molecular alterations in rare coloniccarcinoma subtypes. Formalin-fixed paraffin-embedded(FFPE) tissue was hematoxylin and eosin- and mucicar-mine-stained according to protocol,and immuno-stained with cytokeratin(CK) 7,CK20,CDX2,AE1/AE3,chromo-granin-A and synaptophysin. DNA was extracted from FFPE tissues and molecular analyses were performed according to lab-developed methods,followed by capil-lary electrophoresis. Hematoxylin and eosin staining showed admixed neuroendocrine and keratinized squamous cells. Positive nuclear CDX2 expression confirme dintestinal derivation. CK7 and CK20 were negative.Neuroendocrine cells stained positively for synaptophysin and AE1/AE3 and negatively for chromogranin and mucicarmine. Hepatic metastases showed a similar immunohistochemical profile. Molecular analysis revealeda G13D KRAS mutation. BRAF mutational testing wasnegative and microsatellite instability was not detected.The patient had rapid disease progression on chemotherapy and died 60 d after presentation. Although theG13D KRAS mutation normally predicts an intermed iateoutcome,the aggressive tumor behavior suggests other modifying factors in rare types of colonic carcinomas. | Sabrina C Wentz Cindy Vnencak-Jones William V Chopp | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 2 | (2008) It's time for a change in practice:reducing antibiotic use can alter antibiotic resistance 显示文摘 | Cindy R Friedman Cynthia C Whitney | 2008 | The Journal of Infectious Diseases2008，197，8： | 1 |
| 3 | A broader View of Cells Via High-Content Screening显示文摘 | Cindy C | 2003 | Drug Discovery & Development2003，6，3： | 1 |
| 4 | Regional inequality in China:a case study of Jiangsu province显示文摘 | WEI YEHUA FAN C CINDY | 2000 | Professional Geography2000，52，3： | 1 |
| 5 | Electron transfer at electrodes through conjugated 'Molecular Wire' bridges显示文摘 | Stephen C Yu C J Cindy B etal | 1999 | J Am Chem Soc1999，121，： | 1 |
| 6 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 7 | Regional Inequality in China: A Case Study of Jiangsu Province显示文摘 | Wei Yehua Fan C Cindy | 2000 | Professional Geography2000，，3： | 1 |
| 8 | The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury显示文摘 | IADECOLA C CINDY A | 1999 | J Exp Med1999，189，4： | 1 |
| 9 | Interprovincial migration,population redistribution and regional development in China:1990 and 2000 census comparisons显示文摘 | C Cindy Fan | 2005 | The professional Geographer2005，52，2： | 1 |
| 10 | Grouth and Decline of Muslim Hui Enclaves in Beijing 显示文摘 | Wang wenfei Zhou Shangyi Fan Cindy C | 2002 | Eurasian Geography and Economics2002，43，2： | 1 |
| 11 | Interprovincial migration population redistribution and regional development in China:1990 and 2000 census comparisons显示文摘 | Fan Cindy C | 2005 | The Professional Geographer2005，57，2： | 1 |
| 12 | Comparison of primary and facilitated percutaneous coronary interventions for ST-elevation myocardial infaretion: quantitative review of randomised trials 显示文摘 | Ellen C Keeley Judith A Boura Cindy L Grines | 2006 | Laneet2006，367，9510： | 1 |
| 13 | PA-RISC to IA-64: Transparent Execution, No Recompilation显示文摘 | Zheng Cindy Thompson C | 2000 | IEEE Computer2000，33，3： | 1 |
| 14 | Predicting the level of B2B ecommerce in in- dustrial organizations 显示文摘 | Cindy C | 2005 | Industrial Marketing Management2005，，3： | 1 |
| 15 | Treatment of 1, 2-dibromo-3-chloropropane and niprate-containated water with zero-valent iron or hydrogen,/palladium catalysts显示文摘 | Darsa P S Cindy G S Chou C S | 1996 | Water Res1996，30，10： | 1 |
| 16 | Regional Inequality in China: A Case Study of Jiangsu Province显示文摘 | WEI Yehua FAN C Cindy | 2000 | Professional Geography2000，52，3： | 1 |
| 17 | Interprovincial migration, population redistribution and regional development in China:1990 and 2000 census comparisons显示文摘 | C Cindy Fan | 2005 | The professional Geographer2005，52，2： | 1 |
| 18 | Grouth and Decline of Muslim Hui Enclaves in Beijing显示文摘 | WANG WENFEI ZHOU SHANGYI C CINDY FAN | 2002 | Eurasian Geography and Economics2002，，2： | 1 |
| 19 | Is This Review Believable? A Study of Factors Affecting the Credibility of Online Consumer Reviews from an ELM Perspective显示文摘 | Cheung M Y Cindy M Y Sia C L | 2012 | Journal of the Association for Information Systems2012，13，8： | 1 |
| 20 | What works in prevention:Principles of effective prevention programs显示文摘 | Maury N Cindy C | 2003 | Am Psycol2003，58，67： | 1 |
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