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| 1 | The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding显示文摘瞄准:在成年雄的老鼠上调查粗略的大蒜的效果繁殖功能。方法:三十只雄的老鼠被划分成五个组:组 1 (未经治疗) 并且组 2, 3, 4 和 5 分别地用 5% , 10% , 15% 和 30% 粗略的大蒜被喂 30 天。睾丸和附件机关被称,一些标记被估计。光和电子显微镜学观察也被执行。结果:重要减少在组的体重被观察 4 (14% ;P <
0.01 ) 并且 5 (20% ;P <
0.01 ) ;在组 5 的前列腺重量(29.1% ;P <
0.05 ) 并且在组的精囊重量 3 (14.4% ;P <
0.01 ) , 4 (18.3% ;P <
0.01 ) 并且 5 (27.3% ;P <
0.01 ) 。相反,睾丸和附睾重量是未改变的。在附睾织物,高山哈糖甙酶活动和精子密度是未改变的。处理在组在睾丸激素浆液层次导致了重要减少 3 (77.3% ;P <
0.01 ) , 4 (77.3% ;P <
0.01 ) 并且 5 (90.9% ;P <
0.01 ) ,与 LH 浆液层次的重要增加联系了(P <
0.01 ) 。阴囊的组织学在空细精管的百分比显示出剂量依赖者增加。而且,阴囊的功能被影响;在磷酸酶酸活动的重要减少(P <
0.01 ) 并且睾丸激素(P <
0.05 ) 内容被观察。结论:在 1 个月期间,在 10% , 15% 和 30% 点的减少的睾丸激素分泌物和改变的精子发生开的粗略的大蒜消费。 | Irnen Hammami Afef Nahdi Claire Mauduit Mohamed Benahmed Mohamed Amri Awatef Ben Amar Semy Zekri Ahmed El May Michele Veronique El May | 2008 | Asian Journal of Andrology2008，10，4： | 4 |
| 2 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 3 | Sociodemographic associations with early disease damage in patientswith systemic lupus erythematosus显示文摘 | Cooper GS Treadwell EL St Clair EW | | 0，，06： | 1 |
| 4 | Pulse wave velocity and vascular calcification at different stages of chronic kidney disease显示文摘 | Mohamed Temmar Sophie Liabeuf Cédric Renard Sébastien Czernichow Najeh El Esper Irina Shahapuni Claire Presne Raifah Makdassi Michel Andrejak Christophe Tribouilloy Pilar Galan Michel E Safar Gabriel Choukroun Ziad Massy | 2010 | Journal of Hypertension2010，，1： | 1 |
| 5 | The role of fib rinogen and related fragments in tumor angio genesis and metastasis显示文摘 | Nicola JB Claire EL | 2003 | Expert Opin Biol Ther2003，3，7： | 1 |
| 6 | Severe pigment epithelial alterations in the treatment area following photodynamic therapy for classic choroidal neovascularization in young females显示文摘 | Laurence Postelmans Brigitte Pasteels Pascale Coquelet Hind El Ouardighi Claire Verougstraete Ursula Schmidt-Erfurth | 2004 | American Journal of Ophthalmology2004，，5： | 1 |
| 7 | Distinct role of macrophages in different tumor microenvironments显示文摘 | Claire El Jeffrey WP | 2006 | Cancer Res2006，66，2： | 1 |
| 8 | Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels显示文摘 | Claire M. Williams Manal Abd El Mohsen David Vauzour Catarina Rendeiro Laurie T. Butler Judi A. Ellis Matthew Whiteman Jeremy P.E. Spencer | 2008 | Free Radical Biology and Medicine2008，，3： | 1 |
| 9 | 显示文摘 | Maini R St Clair EW Breedveld F el al | 1999 | Lancet1999，354，： | 1 |
| 10 | The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation显示文摘 | Sahar El Aidy Claire A Merrifield Muriel Derrien Peter van Baarlen Guido Hooiveld Florence Levenez Joel Doré Jan Dekker Elaine Holmes Sandrine P Claus Dirk-Jan Reijngoud Michiel Kleerebezem | 2013 | Gut2013，，9： | 1 |
| 11 | Inflammation and breast cancer microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2 显示文摘 | Claire EL Russell H | 2007 | Breast Cancer Res2007，9，3： | 1 |
| 12 | Simultaneous optimization of capsule and tablet formulation using response surface methodology显示文摘 | Iskandaram B Clair JH Pat el P et at | 1993 | Drug Dev Ind Pharm1993，19，6： | 1 |
| 13 | Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma显示文摘 | Lauren E. Colbert Sarah B. Fisher Claire W. Hardy William A. Hall Burcu Saka Joseph W. Shelton Aleksandra V. Petrova Matthew D. Warren Brooke G. Pantazides Khanjan Gandhi Jeanne Kowalski David A. Kooby Bassel F. El‐Rayes Charles A. Staley N. Volkan Adsay | 2013 | Cancer2013，，： | 1 |
| 14 | Distinct role of macrophages in dif- ferent tumor microenvironments 显示文摘 | Claire EL Jeffrey WP | 2006 | Cancer Res2006，66，： | 1 |
| 15 | Targeting stem cells by radiation: From the biological angle to clinical aspects显示文摘Radiotherapy is a cornerstone of anticancer treatment. However in spite of technical evolutions, important rates of failure and of toxicity are still reported. Although numerous pre-clinical data have been published, we address the subject of radiotherapy-stem cells interaction from the clinical efficacy and toxicity perspective. On one side, cancer stem cells(CSCs) have been recently evidenced in most of solid tumor primary locations and are thought to drive radio-resistance phenomena. It is particularly suggested in glioblastoma, where CSCs were showed to be housed in the subventricular zone(SVZ). In recent retrospective studies, the radiation dose to SVZ was identified as an independent factor significantly influencing overall survival. On the other side, healthy tissue stem cells radio-destruction has been recently suggested to cause two of the most quality of life-impacting side effects of radiotherapy, namely memory disorders after brain radiotherapy, and xerostomia after head and neck radiotherapy. Recent publications studying the impact of a radiation dose decrease on healthy brain and salivary stem cells niches suggested significantly reduced long term toxicities. Stem cells comprehension should be a high priority for radiation oncologists, as this particular cell population seems able to widely modulate the efficacy/toxicity ratio of radiotherapy in real life patients. | Alexis Vallard Sophie Espenel Jean-Baptiste Guy Peng Diao Yaoxiong Xia Anis El Meddeb Hamrouni Majed Ben Mrad Alexander Tuan Falk Claire Rodriguez-Lafrasse Chloé Rancoule Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，8： | 0 |
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