|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dextran sulfate sodium-induced colitis-associated neoplasia:a promising model for the development of chemopreventive interventions显示文摘与 ulcerative 大肠炎诊断的个人面对开发颜色的显著地增加的风险表面的发育异常和癌症在他们的一生期间。迄今为止,注意为葡聚糖硫酸盐钠(决策支持系统)的这个 high-riskpopulation.The 鼠标模型被给了 chemopreventive 干预的开发的很少导致了大肠炎代表两个都描绘面对发炎为肿瘤形成要求的分子的事件并且估计精选代理人的能力到的一个优秀现出症状之前的潜的系统在在长期的大肠炎的建立和颜色的开发喝水结果禁止决策支持系统的 thisprocess.Cyclic 管理有人的联系大肠炎的瘤形成类似于那些的病理学的特征的表面的发育异常和癌症。观察的损害的发生和复合变化取决于使用的鼠标紧张(即,瑞士韦伯斯特, C57BL/6J , CBA , ICR )并且剂量(0.7%-5.0%)和瘤形成的 DSS.Theincidence 的时间表( 1-15 周期与或没有一个随后的恢复时期)能被增加,它到侵略癌症的前进由与已知的冒号致癌物在联合管理决策支持系统显著地加速了( azoxymethane ( AOM ), 2-ammo-3-methylimidazo [ 4,5-f ]喹啉( IQ ), 2-amino-l-methyl-6-phenylimidazo [ 4,5-b ] pyridine ( PhTP ))在遗传上定义的老鼠的联系大肠炎的瘤形成的最近的正式就职拉紧的 oriron.More 提供了新卓见进特定的基因的角色(即, adenomatous polyposiscoli ( Apc ), p53 ,可诱导的氮的氧化物 synthase ( i NOS ), Msh2 )在从 chemopreventive 干预的 colitis-associatedneoplasias.Emerging 数据的开发,研究在禁止导致决策支持系统的瘤形成记录几个代理人的功效并且提供 colitis-associatedcolorectal 瘤形成是可防止的疾病的大诺言。 | Margie Lee CLAPPER Harry Stanley COOPER Wen-Chi Lee CHANG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 17 |
| 2 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 3 | A role for 2-araehi- donoylglyeerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy 显示文摘 | Eisenstein SA Clapper JR Holmes PV | 2010 | Pharmacol Res2010，61，5： | 1 |
| 4 | Clinical series of oncoplasticmastopexy to optimize cosmesis of large-volume resections for breastconservation显示文摘 | Bong J Parker J Clapper R | 2010 | Ann Surg Oncol2010，17，12： | 1 |
| 5 | 显示文摘 | McClung W G Clapper D L Hu S P | 2000 | Biomed Mater Res2000，49，3： | 1 |
| 6 | Effects of high-protein/low-carbohydrate swine diets during the final finishing phase on pork muscle quality显示文摘 | Leheska J M Wulf D M Clapper J A Thaler R C Maddock R J | 2002 | Journal of Animal Science2002，80，1： | 1 |
| 7 | A comparison of obstetric maneuvers for the acute management of shoulder dystocia显示文摘 | Clapper TC Gross SJ Wilcox WC | 2012 | Obstet Gynecol2012，119，21： | 1 |
| 8 | Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse显示文摘 | Harvey H. Hensley Carrie E. Merkel Wen-Chi L. Chang Karthik Devarajan Harry S. Cooper Margie L. Clapper | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 9 | A red blood cell autoanti- body with mimicking anti-E specificity显示文摘 | Dwyre DM Clapper A Heintz M | 2004 | Transfusion2004，44，9： | 1 |
| 10 | Endoscopic treatment of carpal tunnel syndrome:a critical review显示文摘 | Jimenez DF Gibbs SR Clapper AT | 1998 | Neurosurg1998，88，5： | 1 |
| 11 | CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations显示文摘 | Lee K M Kang D Clapper M L | 2008 | Cancer Epidemiol Biomarkers Prey2008，17，5： | 1 |
| 12 | Prognostic value of free plasma homocysteine levels in patients hospitalized with acute coronary syndrome 显示文摘 | Van Oijen MG Claessen BE Clappers N | 2008 | Am J Cardiol2008，102，2： | 1 |
| 13 | Joint development of an environmentally acceptable ester based drilling fluid显示文摘 | Amin R A M Clapper D K Norfleet J E | | SPE0，，： | 1 |
| 14 | Early screw fixa-tion versus casting in the treatment of acute Jones fractures显示文摘 | Mologne TS Lundeen JM Clapper MF | 2005 | Am J Sports Med2005，33，7： | 1 |
| 15 | Effects of high-protein/low-carbohydrate swine diets during the final finishing phase on pork muscle quality显示文摘 | Leheska J M Wulf D M Clapper J A Thaler R C Maddock R J | 2002 | J Anim Sci2002，80，： | 1 |
| 16 | Prognostic value of free plasma homocysteine levels in patients hospitalized with acute coronary syndrome显示文摘 | van Oijen MG Claessen BE Clappers N | | 0，，02： | 1 |
| 17 | Aluminum Based HP WBM Successfully Replaces Oil Based Mud to Drill Exploratory 显示文摘 | Ramirez M A Clapper D K | | SPE0，，： | 1 |
| 18 | Ileal and total tract nutrient digestibilities and fecal characteristics of dogs as affected by soybean protein inclusion in dry,extruded diets显示文摘 | Clapper G M Grieshop C M Merchen N R | 2001 | J Anim Sci2001，79，： | 1 |
| 19 | Endoscopic treatment of carpal tunnel syndrome : a critical review 显示文摘 | Jimenez DF Gibbs SR Clapper AT | 1998 | J Neurosurg1998，88，5： | 1 |
| 20 | Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of oral cavity 显示文摘 | Liu SC Sauter ER Clapper ML | 1998 | Cancer Epidemiol Biota Prevention1998，7，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员