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| 1 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | 受控导线断线时输电铁塔的实测动态特性显示文摘英国在1条退役的输电铁塔上进行了断线事件的现场模拟测试,研究了传递到输电铁塔塔腿的负载分布、负载传递速率。在土工离心机中进行了相似的物理模型研究,给出了负载传递速率和承载系数(Ns)的关系。 | M CLARK D J RICHARDS D CLUTTERBUCK 何鹏(翻译) 马明(编校) | 2007 | 电力建设2007，28，5： | 2 |
| 4 | Antifungal evaluation of pseudolaric acid B, a major constituent of pseudolarix kaempferi显示文摘 | Li E Clark A M Hufford C D | 1995 | J Nat Prod1995，58，： | 1 |
| 5 | A novel integrated in vitro maturation and in vitro fertilization system for swine显示文摘 | Clark S G Walters E M Beebe D J | 2003 | Theriogenology2003，59，： | 1 |
| 6 | Ceil contact as an independent factor moduletating cardiac myocytes hypertrophy and survival in long-term primary culture显示文摘 | Clark W A Decker M L Janes D M | 1998 | J Mol Cell Cardiol1998，30，： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Use of a peptide rather than free amino acid nitrogen source in chemically defined 'elemental' diets显示文摘 | SILK D B A FAIRCLOUGH P D CLARK M L | 1980 | Journal of Parenteral and Enteral Nutrition1980，4，： | 1 |
| 9 | Structure,antifer-romgnetism and superconductivity of the layered iron arsenide NaFeAs显示文摘 | Parker D R Pitcher M J Clarke S J | 2009 | Chem Commun2009，28，16： | 1 |
| 10 | The effects of proton irradiation on the RF performance of SiGe HBTs 显示文摘 | ZHANG S M CRESSLER J D CLARK S D | 1999 | IEEE Transactions on Nuclear Science1999，46，6： | 1 |
| 11 | Identification of a cancer stem cell in human brain tumors显示文摘 | Singh S K Clarke I D Terasaki M | 2003 | Cancer Res2003，63，18： | 1 |
| 12 | Markov random field for tumor detection in digital mammography 显示文摘 | Li H D MKallergi M Clarke L P | 1995 | IEEE Trans Medial Imaging1995，14，： | 1 |
| 13 | The split-cavity oscillator: a high-power e-beam modulator and microwave source显示文摘 | Marder B M Clark M C Bacon L D | 1992 | IEEE Trans on Plasma Science1992，20，3： | 1 |
| 14 | Random and site -specific immobilization of catalytic antibodies 显示文摘 | Spitznagel T M Jacobs J W Clark D S | 1993 | Enzyme Microbial Technol1993，15，： | 1 |
| 15 | Self- assembling organic nanotubes 显示文摘 | Bong D T Clark T D Granja J R Ghadiri M R | 2001 | Angew Chem Int Ed Engl2001，40，6： | 1 |
| 16 | Magnetically insulated transmission line oscillator显示文摘 | Clark M C Marder B M Bacon L D | 1988 | Appl Phys Lett1988，52，1： | 1 |
| 17 | Functional consequences of alterations to polar amino acids located in the transmembrane domain of the Ca^2+ -ATPase of sareoplasmic reticulum 显示文摘 | Clark M Leo T W Maelerman D H | 1990 | J Biochem1990，265，11： | 1 |
| 18 | Spectral discrimination of coral mortality states following a severe bleaching event 显示文摘 | CLARK C D MUMBY P J CHISHOLM J R M | 2000 | International Journal of Remote Sensing2000，21，11： | 1 |
| 19 | Determination of width of meander-belt sandstone reservoirs from vertical downhole data,Mesaverde Group,Piceance Greek Basin,Colorado显示文摘 | LORENZ J C HEINZE D M CLARK J A | 1985 | AAPG Bulletin1985，69，5： | 1 |
| 20 | BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer 显示文摘 | Xing M Clark D Guan H | 2009 | J Clin Oncol2009，27，18： | 1 |
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