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| 1 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Timing, method and discontinuation of hydrocortisone administration for septic shock patients显示文摘AIM To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes.METHODS This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone.It was performed at 2 critical care units in academic hospitals from June 1st, 2015, to July 31 st, 2016. Demographic data, comorbidities, medical management details, adverse effects related to corticosteroids, and outcomes were collected after the critical care physician indicated initiation of hydrocortisone. Univariate comparison between continuous and bolus administration of hydrocortisone was performed, including multivariate analysis, as well as Kaplan-Meier analysis to compare the proportion of shock reversal at 7 d after presentation. Receiver operating characteristic(ROC) curves determined the best cut-off criteria for initiation of hydrocortisone associated with the highest probability of shock reversal. We addressed the effects of the taper strategy for discontinuation of hydrocortisone, noting risk of shock relapse and adverse effects.RESULTS All-cause 30-d mortality was 42%. Hydrocortisone was administered as a continuous infusion in 54.2% of patients; time to reversal of shock was 49 h longer in patients who were given a bolus administration [59 h(range, 47.5-90.5) vs 108 h(range, 63.2-189); P = 0.001]. The maximal dose of norepinephrine after initiation of hydrocortisone was lower in patients on continuous infusion [0.19 μg/kg per minute(range, 0.11-0.28 μg)] compared with patients who were given bolus [0.34 μg/kg per minute(range, 0.16-0.49); P = 0.004]. Kaplan-Meier analysis revealed a higher proportion of shock reversal at 7 d in patients with continuous infusion compared to those given bolus(83% vs 63%; P = 0.004). There was a good correlation between time to initiation of hydrocortisone and time to reversal of shock(r = 0.80; P < 0.0001); ROC curve analysis revealed that the best criteria for prediction of shock reversal was a time to initiation of hydrocortisone of ≤ 13 h after administration of norepinephrine, with an area under the curve of 0.81(P < 0.001). The maximal dose of norepinephrine at initiation of hydrocortisone with the highest association with shock reversal was ≤ 0.28 μg/kg per minute, with an area under the curve of 0.75(P = 0.0002). On a logistic regression model, hydrocortisone taper was not associated with a lower risk of shock relapse(RR = 1.29; P = 0.17) but was related to a higher probability of hyperglycemia [odds ratio(OR), 5.3; P = 0.04] and hypokalemia(OR = 10.6; P = 0.01). CONCLUSION Continuous infusion of hydrocortisone could hasten the resolution of septic shock compared to bolus administration. Earlier initiation corresponds with a higher probability of shock reversal. Tapering strategy is unnecessary. | Miguel A Ibarra-Estrada Quetzalcóatl Chávez-Pe?a Claudia I Reynoso-Estrella Jorge Rios-Zerme?o Pável E Aguilera-González Miguel A García-Soto Guadalupe Aguirre-Avalos | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 3 | Differential regulation of lipopolysaccharideactivation pathways in mouse macrophages by LPS-binding proteins显示文摘 | Claudia R A Takayuki K Noriko I | 1998 | JImmunol1998，161，4： | 1 |
| 4 | Proteolysis in model Portuguese cheeses: effects of rennet and starter culture 显示文摘 | Claudia I | 2008 | Food Chemistry2008，108，： | 1 |
| 5 | Heat recovery from Diesel engines:A thermodynamic com- parison between Kalina and ORC cycle 显示文摘 | BOMBARDA P COSTANTE M I CLAUDIA P | 2010 | Applied Thermal Engineering2010，33，23： | 1 |
| 6 | Urolithin A causes p21 up regulation in prostate cancer cells 显示文摘 | Claudia S G Carlos J C Maria I P | 2015 | Eur J Nutr2015，55，3： | 1 |
| 7 | Detection of Babesia cohalli infection by enzyme-linked immunosorbent assay using recombinant 48-kDa merozoite rhoptry protein显示文摘 | Hiromi I Claudia RO Xuan XN | 2000 | Int J Parasitol2000，30，5： | 1 |
| 8 | CT screening for lung cancer显示文摘 | Claudia I David F | 2000 | RCNA2000，38，： | 1 |
| 9 | How surface fire in Siberian Scots pine forests affects soil organic carbon in the forest floor:Stocks,molecular structure,and conversion to black carbon (charcoal)显示文摘 | Claudia I Czimczik Caroline M | 2003 | Global Biogeochemical Cycles2003，17，1： | 1 |
| 10 | p27kip1-838C》A Single nucleotidePolymorphism is associated with restenosis risk after coronary stenting and modulatesP27kip1Promoter ac-tivity显示文摘 | Claudia M Peter I Rrttersma SZH | 2009 | Circulation2009，120，8： | 1 |
| 11 | Myocardi- al reperfusion injury: Reactive oxygen species vs NHE-1 reactiva- tion 显示文摘 | CAROLINA D G JULIANA C F CLAUDIA I C | 2011 | Cell Physiol Biochem2011，27，1： | 1 |
| 12 | A competence-based and multidimensional operationalization and measurement of employability显示文摘 | Claudia M Van Der Heijde Beatrice I J M Van Der Heijden | 2006 | Human Resource Management2006，45，3： | 1 |
| 13 | Are Remnant-Like Particles Independent Predictors of Coronary Heart Disease Incidence? The Honolulu Heart Study显示文摘 | Claudia I Beatriz L R John SG | 2005 | Arterioscler Thromb Vasc Biol2005，25，8： | 1 |
| 14 | Influence of biochar on drought tolerance of Chenopodium quirtoa willd and on soil-plant rela- tions显示文摘 | Claudia I K Sebastian L Johannes W | 2011 | Plant Soil2011，345，： | 1 |
| 15 | A comparative analysis of wolf diet in three different Italian ecosystems 显示文摘 | Claudia C Bertelli I | 2004 | Mammalian Biology2004，69，1： | 1 |
| 16 | Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion - induced acute renal failure in rats 显示文摘 | Claudia L Florian T Harald I | 2005 | Kidney Int2005，68，4： | 1 |
| 17 | crit- ical step in the folding of influenza virus HA determined with a novel folding assay 显示文摘 | M Claudia Maggioni I Marije Liscaljet Ineke Braakman | 2005 | Nature Structural & Molecular Biology2005，12，3： | 1 |
| 18 | Small solitary pulmonary nodules显示文摘 | DAVID F YANKELEVITZ M D CLAUDIA I HENSCHKE | 2000 | Lung Cancer2000，38，3： | 1 |
| 19 | Solubilization of tropicamide by hydroxypropyl-β-cyclodextrin and water-soluble polymers: in vitro/in vivo studies显示文摘 | Brunella C Claudia C Maria I | 2001 | Int J Pharm2001，213，： | 1 |
| 20 | The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells显示文摘 | Fernando Romaine I Litzinger Mary Trono Paola Hamilton Duane H Schlom Jeffrey Palena Claudia | 2010 | Journal of Clinical Investigation2010，，2： | 1 |
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