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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Using riskranking of metals to identify which poses the greatest threat to freshwater organisms in the UK显示文摘 | Rachel L R Andrew C J Claudia M | 2014 | Environmental Pollution2014，194，： | 1 |
| 3 | Polymorphism in repeated 16SrRNA genes is a common property of type strains and envi-ronmental isolates of the genus Vibrio 显示文摘 | Claudia M Jaime R Romilio T | 2002 | Microbiology?2002，148，： | 1 |
| 4 | Effieieneies of different genes and different tree-building methods in re- covering a know vertebrate phylogeny显示文摘 | CLAUDIA A M R NAOKO T MASATOSHI N | 1996 | Molecular Biology Evo- lution1996，13，3： | 1 |
| 5 | Virostatic po tential of micro-nano filopodia-like ZnO structures against her pes simplex virus-l显示文摘 | Yogerrdra Kumar M Rainer A Claudia R | 2011 | Published in final edited form as:Anti viral Res2011，92，2： | 1 |
| 6 | Accumulation and partitioning of heavy metals in mangroves: A synthesis of field-based studies 显示文摘 | Geoff R M Claudia E K Simon P B | 2007 | Chemosphere2007，69，9： | 1 |
| 7 | Cloning of a eDNA encoding a cystatin from grain amaranth (Amaranthus hypochondriacus) showing a tissue-specific expression that is modified by germination and abiotic stress显示文摘 | SILVIA V R ARMANDO G R CLAUDIA M V | 2007 | Plant Physiology and Biochemistry2007，45，1011： | 1 |
| 8 | Decolorization of reactive dyes by immobilized laccase显示文摘 | PATRICIO P Z CLAUDIA M P ELAINE R L | 2003 | Applied Catalysis B:Environmemal2003，42，2： | 1 |
| 9 | Intermittent acti- vation of bradykinin B2 receptor and mitochondrial KATP channels trigger cardiac postconditioning through redox sig- naling显示文摘 | Claudia P Daniele M Raffaelta R | 2007 | Cardiovasc Res2007，75，1： | 1 |
| 10 | Supporting modeling and problem solving from precedent experiences : the role of workflows and case - based reasoning 显示文摘 | Daniel S K Claudia B M Heloisa V R | 2005 | Environmental Modelling & Software2005，20，6： | 1 |
| 11 | Determinants of farmers' choice of adaptation methods to climate change in the Nile Basin of Ethiopia 显示文摘 | Temesgen T D Rashid M H Claudia R | 2009 | Global Environmental Change2009，19，2： | 1 |
| 12 | The body-mass index,airflow obstruction,dyspnea,and exercise capacity index in chronic obstructive pulmonary disease显示文摘 | Bartolome R Celli Claudia G Cote Jose M Marin | 2004 | The New England Journal of Medicine2004，350，10： | 1 |
| 13 | In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E- that targets integrin αvβ3 显示文摘 | CLAUDIA R HAGIT M S MARTIN L B | 2009 | Int J Pharm2009，368，12： | 1 |
| 14 | Cardioprotection: A radical view Free radicals in pre and postconditioning 显示文摘 | Claudia P Daniele M Raffaella R | 2009 | Biochimiea et Biophysica Acta2009，1787，： | 1 |
| 15 | Enterotoxins,colonization factors,serotypes and antimicrobial resistance of enterotoxigenic Escherichia coli(ETEC)strains isolated from hospitalized children with diarrhea in Bolivia显示文摘 | Claudia R Rosalía M Jorge B | 2011 | The Brazilian Journal of Infectious Diseases2011，15，2： | 1 |
| 16 | Polymorphism in re- peated 16S rRNA genes is a common property of type strains and environmental isolates of the genus Fibrio显示文摘 | Claudia M Jaime R Romilio T | 2002 | Microbiology2002，148，4： | 1 |
| 17 | Plant grow promoting properties of a strain of Enterobacter ludwigii isolated firom Lolium pernne rhizosphere显示文摘 | Mauricio S Claudia M R Martin A P | 2008 | Soil Biology and Biochemistry2008，41，2009： | 1 |
| 18 | Effects of vitrification in open pulled straws on the cytology of invitro matured prepubertal and adult bovine oocytes 显示文摘 | JoseL A Roser M Claudia R | 2005 | Theriogenology2005，63，： | 1 |
| 19 | Polymorphism in repeated 16S r RNA genes is a common property of type strains and environmental isolates of the genus Vibrio显示文摘 | Claudia M Jaime R Romilio T E | 2002 | Microbiology2002，148，： | 1 |
| 20 | The low level laser therapy in the management of neurological burning mouth syndrome: a pilot study显示文摘 | Umberto R Claudia M Maurizio R | 2010 | Annali distomotologia2010，1，： | 1 |
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