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| 1 | Portal vein thrombosis:Insight into physiopathology,diagnosis,and treatment显示文摘Portal vein thrombosis (PVT) is a relatively common complication in patients with liver cirrhosis, but might also occur in absence of an overt liver disease. Several causes, either local or systemic, might play an important role in PVT pathogenesis. Frequently, more than one risk factor could be identified; however, occasionally no single factor is discernable. Clinical examination, laboratory investigations, and imaging are helpful to provide a quick diagnosis, as prompt treatment might greatly affect a patient's outcome. In this review, we analyze the physiopathological mechanisms of PVT development, together with the hemodynamic and functional alterations related to this condition. Moreover, we describe the principal factors most frequently involved in PVT development and the recent knowledge concerning diagnostic and therapeutic procedures. Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses. | Francesca R Ponziani Maria A Zocco Chiara Campanale Emanuele Rinninella Annalisa Tortora Luca Di Maurizio Giuseppe Bombardieri Raimondo De Cristofaro Anna M De Gaetano Raffaele Landolfi Antonio Gasbarrini | 2010 | World Journal of Gastroenterology2010，16，2： | 75 |
| 2 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 3 | May the Shields theory be extended to cohesive and adhesive benthic sediment 显示文摘 | Maurizio R Corrado L | 2007 | Journal of Ge- ophysical Research2007，112，10： | 1 |
| 4 | Detection of genetically modified organisms(GMOs ) using isothermal amplification of target DNA sequences显示文摘 | David Lee Maurizio La Mura Theo R Allnutt | 2009 | BMC Biotechnology2009，，9： | 1 |
| 5 | Photochemical degradation of crude oil:Comparison between direct irradiation,photocatalysis,and photo-catalysis on zeolite显示文摘 | Maurizio D A Lucia E Rocco R | 2009 | J Hazard Mater2009，164，： | 1 |
| 6 | Recombinant Apolipoprotein A-I sub Milano Dimer Inhibits Carotid Intimal Thickening Induced by Perivascular Manipulation in Rabbits显示文摘 | Soma Maurizio R Donetti | 1995 | Circ Res1995，76，3： | 1 |
| 7 | Predictive factors of mortality from nonvariceal upper gastrointestinal haemorrhage: a muhicentre study显示文摘 | Marmo R Maurizio K Cipolletta L | 2008 | Am J Gastroenterol2008，103，1： | 1 |
| 8 | Plasmon nano-optical tweezers 显示文摘 | MATHIEU L J MAURIZIO R ROMAIN Q | 2011 | Nature Photonics2011，5，6： | 1 |
| 9 | Endoscopic endonasal approaches for repair of eerebrospinal fluid leaks : nine-year experience显示文摘 | Davide L Federico R Maurizio B | 2006 | Neurosurgery2006，58，2： | 1 |
| 10 | PEComas: The past, the present and the future 显示文摘 | Guido M Maurizio P Daniela R | 2008 | Virchows Arch2008，452，： | 1 |
| 11 | Reverse dorsal dig it ali slandf lap显示文摘 | Masssimo DB Maurizio P Piero R | 1994 | P last Recoastr surg1994，93，： | 1 |
| 12 | Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction显示文摘 | Margherita M Vittorio R Maurizio F | 2004 | Blood2004，2，： | 1 |
| 13 | Partial purification,structure and infectivity of complete ma/ze rough dwarf virus particles显示文摘 | Milne R G Maurizio Conti Vittoria Lisa | 1973 | Virol- ogy1973，53，1： | 1 |
| 14 | A survey of kernel and spectral methods for clustering显示文摘 | Maurizio F Francesco C Francesco M Stefano R | 2008 | Pattern Recognition2008，，41： | 1 |
| 15 | Triterpenoids from salvia deserta 显示文摘 | GIUSEPPE S MAURIZIO B BENJAMIN R | 1987 | Phytochemistry1987，26，12： | 1 |
| 16 | Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction 显示文摘 | Margherita M Vittorio R Maurizio F | 2005 | Blood2005，105，： | 1 |
| 17 | Streamwise-travelling waves of spanwise wall velocity for turbulent drag reduction显示文摘 | Maurizio Q Pierre R Claudio V | 2009 | Journal of Fluid Mechanics2009，627，： | 1 |
| 18 | Impact on vehicle fuel economy of the soot loading on diesel par- ticulate filters made of different substrate materials 显示文摘 | Federico M Maurizio A Mahsa R | 2015 | Energy2015，86，： | 1 |
| 19 | Profile of bazedoxifene/con- jugated estrogens for the treatment of estrogen deficiency symptoms and osteoporosis in women at risk of fracture显示文摘 | Maurizio R Stefano L Ignazio S | 2013 | Drug Des Devel T- her2013，7，： | 1 |
| 20 | Oral assessment ofchildren with an autism spectrum disorder显示文摘 | DeMattei R Cuvo A Maurizio S | 2007 | J Dent Hyg2007，81，3： | 1 |
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