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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 3 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 4 | Patient outcomes in the field of nursing: A concept analysis显示文摘Purpose:This paper reports an analysis of the concept of patient outcomes.Methods:The Walker and Avant concept analysis approach was applied.Results:The attributes of patient outcomes include(1)patient functional status(maintained or improved),(2)patient safety(protected or unharmed),and(3)patient satisfaction(patient reporting of comfort and contentment).These attributes are influenced by the antecedents of individual patient characteristics and health problems,the structure of healthcare organizations and received health interventions.Additionally,patient outcomes do significantly impact the quality of nursing care,the cost of effective care and healthcare policy making formulation.Conclusion:Providing good nursing care to all patients is a central goal of nursing.Patient outcomes in nursing are primarily about the results for the patient receiving nursing care.This analysis provides nurses with a new perspective by helping them to understand all the components within the concept of patient outcomes. | Ying Liu Kay Coalson Avant Yupin Aungsuroch Xin-Yu Zhang Ping Jiang | 2014 | International Journal of Nursing Sciences2014，1，1： | 2 |
| 5 | Myeoplasma pneumoniae CARDS toxin induces pulmonary eosinophilie and lymphocytic inflam- mation 显示文摘 | Medina JL Coalson JJ Brooks EG | 2012 | Am J Respir Cell Mol Biol2012，46，： | 1 |
| 6 | Synthesis anddistribution of CARDS toxin during Mycoplasma pneumoniaeinfection in a murine model 显示文摘 | Kannan TR Coalson JJ Cagle M | 2011 | J Infect Dis2011，204，10： | 1 |
| 7 | Epidemiology of immune thrombocytopenic purpnra in the general practice re search database显示文摘 | Schoonen WM Kucera G Coalson J | 2009 | Br J Haematol2009，145，2： | 1 |
| 8 | Pathology of new bronchopulmonary dysplasia显示文摘 | Coalson JJ | 2003 | Seminars in neonatology : SN2003，8，1： | 1 |
| 9 | Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin 显示文摘 | Hardy RD Coalson JJ Peters J | 2009 | PLoS One2009，4，10： | 1 |
| 10 | Deficiencies in lung surfactant protein A and D are associated with lung infection in very prematture neonatal baboons显示文摘 | Shanjana A Jacqueline J Coalson | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 11 | Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin a deficient mice显示文摘 | Murthy AK Sharma J Coalson JJ | 2004 | Cell Immunol2004，230，1： | 1 |
| 12 | Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilie and lymphocytic inflammation显示文摘 | MEDINA J L COALSON J J BROOKS E G | 2012 | Am J Respir Cell Mol Biol2012，46，6： | 1 |
| 13 | Calcium and phosphorus requirements of young pigs reared under controlled environmental conditions显示文摘 | Coalson J A Maxwell C V Hillier J C | 1972 | Journal of Aminal Science1972，35，： | 1 |
| 14 | Homology modeling and molecular dynamics simulations of the alpha1 glycine receptor reveals different states of the channel显示文摘 | Cheng M H Cascio M Coalson R D | 2007 | Proteins2007，68，2： | 1 |
| 15 | Pathology of new bronchopulmonary dysplasia 显示文摘 | Coalson 11 | 2003 | Semin Neonatol2003，8，1： | 1 |
| 16 | Pathology of new bronchopulmonary dysplasia 显示文摘 | Coalson JJ | 2003 | Semin Neonatol2003，8，1： | 1 |
| 17 | Fatal Outecomes in family transmission of Mcoplasma pneumoniae显示文摘 | Kannan TR Hardy RD Coalson JJ | 2012 | Clin Infect Dis2012，54，： | 1 |
| 18 | Fatal outcomes in family transmission of Mycoplasma pneumoniae 显示文摘 | Kannan TR Hardy RD Coalson J | 2012 | Clin Infect Dis2012，54，2： | 1 |
| 19 | Escherichia'coli shock in the baboon and the response to adrenocorticosteroid treatment显示文摘 | Hinshaw LB Coalson JJ Benjamin BA | 1978 | Surg Gynecol Obstet1978，147，4： | 1 |
| 20 | Pathology of bronchopulmonary dysplasia显示文摘 | Coalson J J | 2006 | Semin Perinatol2006，30，4： | 1 |
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