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| 1 | 肝素使用和监控指南显示文摘肝素是天然氨基葡聚糖,由肥大细胞产生。药用的肝素由猪或牛的黏膜中提取。肝素由糖醛酸链和葡糖胺链交替组成,含多少不等的硫酸根,相对分子质量5ku-35ku。现在使用的制剂平均相时分子质量(MW)为13ku~15ku,比活性180—220u/mg。 | Baglin T Barrowcliffe TW Coben A Greaves M 陈君敏 曾开淇 | 2006 | 血栓与止血学2006，12，1： | 13 |
| 2 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 3 | The integration of facial skeletal variants 显示文摘 | Coben SE | 2009 | Am J Orthod2009，41，6： | 1 |
| 4 | Local music policies within a global music industry:cultural quarters in Manchester and Sheffield 显示文摘 | Brown A O'Connor J Coben S | 2000 | Geoforum2000，31，4： | 1 |
| 5 | Protection of ovarian function and fertility using a combination of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist during cancer treatment in young females显示文摘 | Fishman A Coben I | 2007 | Gynecol Endocrinol2007，23，5： | 1 |
| 6 | Anassessment of statin safety by muscle seperts显示文摘 | Anania FA Chalasani N | 2006 | Am J Cardiol2006，97，8： | 1 |
| 7 | Reputation Building:Small Business Strategies for Sueeessful venture Development显示文摘 | Albert L Goldberg Gilat Coben and Fiegenbaum | 2003 | Journal ofSmall Business Management2003，，4： | 1 |
| 8 | The integration of facial skeletal variants显示文摘 | Coben SE | 1955 | Am J Orthod1955，41，6： | 1 |
| 9 | Altered contractility of urinary bladder in diabetic rabbits:relationship to reduced Na+ pump activity显示文摘 | Yang S Coben RA | 1996 | Am J Physiol1996，271，61： | 1 |
| 10 | An evaluation of a virtual reality airway simulator显示文摘 | Rowe R Coben RA | 2002 | Anesth Analg2002，95，： | 1 |
| 11 | Enhancing training effects in neurorehabilitation after chronic stroke:cortical stimulation,drugs,and somatosensory input显示文摘 | Coben LG | 2006 | Neurorehabilitation&Neural Repair2006，20，： | 1 |
| 12 | Meta-nalysis of the morning excess of acute myocardial infarction and sudden cardiac death显示文摘 | COBEN M C ROHTLA K M LAVERY C E | 1997 | Am J Cardial1997，79，11： | 1 |
| 13 | A comparison of low-molecular weight heparin with unfractionated heparin for unstable coronary artery disease显示文摘 | Demers C Gurfinkel EP | 1997 | N Engl J Med1997，337，： | 1 |
| 14 | Magnetic resonance differentiation of acute and chronic osteomyelltis in children 显示文摘 | COBEN M D CORY D A KLEIMAN M | 1990 | Clin Radiol1990，41，1： | 1 |
| 15 | Cochlear implantation in children younger than 2 years old显示文摘 | Coben NL | 1998 | Am J Otol1998，19，： | 1 |
| 16 | Anassessment of statin safety by muscle seperts显示文摘 | Coben DE Anania FA Chalasani N | 2006 | Am J Cardiol2006，97，8： | 1 |
| 17 | Complications of gastrectomy following CPT-11-based neoadjuvant chemotherapy for gastric cancer显示文摘 | Marcus SG Coben D Lin K | | 0，，08： | 1 |
| 18 | Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosimephilic granuloma of bone显示文摘 | Coben M Zornoza J | 1980 | Radiology1980，136，4： | 1 |
| 19 | An arithetic characterization of the conjugate quadrature filter associateu to ortlonormal wavelet bases显示文摘 | Coben A Sun Qiyu | 1993 | SIAMJ Math Anal1993，24，： | 1 |
| 20 | A long-term study of the effects of antiviral therapy on survival of patients with HBV-associ- ated hepatocellular carcinoma(HCC) following local tumor abla- tion 显示文摘 | Hann HW Coben R Brown D | 2014 | Cancer Med2014，3，2： | 1 |
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