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| 1 | 中国的炭疽杆菌DNA分型及其地理分布显示文摘炭疽广泛分布于中国各地 ,特别是西部地区 ,并经常造成人畜疾病。在一项合作研究中 ,用多位点VNTR分析 (MLVA)对从 195 2~ 1998年自中国主要地理流行区域分离的病人、病畜和土壤等来源的炭疽杆菌进行了基因分型。MLVA分析结果揭示了 2 1种新的基因型 ,其等位基因组合在以前世界范围分离物的研究中未曾发现。此外 ,分离物的分群显示 ,A3b组是地理上最广泛分布的基因组 ,说明该组可能是中国的“地方流行株”。 | 王秉翔 SmithKL Keys C Coker P Keimp Jones M H | 2002 | 微生物学免疫学进展2002，30，1： | 22 |
| 2 | Progress in surgical and nonsurgical approaches for hepatocellular carcinoma treatment显示文摘BACKGROUND:Hepatocellular carcinoma(HCC) is a complex and heterogeneous malignancy,frequently occurs in the setting of a chronically diseased organ,with multiple confounding factors making its management challenging.HCC represents one of the leading causes of cancer-related mortality globally with a rising trend of incidence in some of the developed countries,which indicates the need for better surgical and nonsurgical management strategies.DATA SOURCES:Pub Med database was searched for relevant articles in English on the issue of HCC management.RESULTS:Surgical resection represents a potentially curative option for appropriate candidates with tumors detected at earlier stages and with well-preserved liver function.The long-term outcome of surgery is impaired by a high rate of recurrence.Surgical approaches are being challenged by local ablative therapies such as radiofrequency ablation and microwave ablation in selected patients.Liver transplantation offers potential cure for HCC and also correction of underlying liver disease,and minimizes the risk of recurrence,but is reserved for patients within a set of criteria proposed for a prudent allocation in the shortage of donor organs.Transcatheter locoregional therapies have become the palliative standard allowing local control for intermediate stage patients with noninvasive multinodular or large HCC who are beyond the potentially curative options.The significant survival benefit with the multikinase inhibitor sorafenib for advanced HCC has shifted the direction of research regarding systemic treatment toward molecular therapies targeting the disregulated pathways of hepatocarcinogenesis.Potential benefit is suggested from simultaneous or sequential multimodal therapies,and optimal combinations are being investigated.Despite the striking progress in preclinical studies of HCC immunotherapy and gene therapy,extensive clinical trials are required to achieve successful clinical applications of these innovative approaches.CONCLUSION:Treatment decisions have become increasingly complex for HCC with the availability of multiple surgical and nonsurgical therapeutic options and require a comprehensive,multidisciplinary approach. | Ender Gunes Yegin Erkan Oymac1 Emrah Karatay Ahmet Coker | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 14 |
| 3 | 血液处理过程中的红细胞溶血显示文摘输注的红细胞制品中红细胞发生溶血已有报道,这对于需要输血的病人具有重要的临床意义。因为游离血红蛋白将裂解成二聚体与结合珠蛋白结合,进而通过网状内皮系统清除,一旦超出结合珠蛋白的结合能力,将会发生血红蛋白血症。溶血是指红细胞破坏后释放出血红蛋白并引起血浆颜色改变。红细胞异常溶血由许多因素引起,包括在血液处理过程中操作不当、保存条件不当、细菌性溶血、抗体激活补体的溶血、红细胞膜的缺陷及献血者异常等。溶血的程度常用红细胞比容校正后的整个血红蛋白中游离血红蛋白的百分率来表示。北美尚未建立可被接受的溶血范围,但是1%溶血标准目前用于评估血液贮存材料的生物相容性,而欧洲委员会将标准定为0.8%。本文强调要对全血制备红细胞的全程进行充分的监控,从而减少溶血的发生。仔细评估血液制备过程将降低因溶血而废弃的红细胞量。 | Samuel O.Sowemimo Coker 张海琴 吕沁风 | 2003 | 国外医学(输血及血液学分册)2003，26，1： | 9 |
| 4 | 俄罗斯Samara州医务人员结核病发病率上升:登记数据分析显示文摘地点:俄罗斯Samara州。目标:比较俄罗斯某地结核病机构医务人员、综合医疗机构医务人员和普通人群的结核病发病率。方法:分析1994-2002年的9年期间结核病机构医务人员、综合医疗机构医务人员和普通人群的结核病登记率。结果:从1994到2002年,Samara州结核病机构医务人员的结核病发病率比普通人群的发病率高10倍,达到741.6/10万人年。结核病机构住院部医务人员的发病率最高,其发病率与综合医院医务人员发病率的率比为17.7(95%可信区间为11.6-27.0)。结论:俄罗斯结核病机构医务人员的结核病发病率显著上升,提示院内感染的危险很大。控制俄罗斯院内结核病传播是一个需要迫切关注的问题,尤其是俄罗斯目前正面临着人类免疫缺陷病毒的流行。 | B. Dimitrova A. Hutchings R. Atun F. Drobniewski G. Marchenko S. Zakharova I. Fedorin R. J. Coker 徐敏 | 2005 | 结核与肺部疾病杂志2005，8，2： | 7 |
| 5 | Comparison of three PCR methods for detection of Helicobacter pylori DNA and detection of cagA gene in gastric biopsy specimens显示文摘AIM: To comparatively evaluate PCR and other diagnostic methods (the rapid urease test and / or culture) in order to determine which of the three PCR methods (ureA, glmM and 26-kDa, SSA gene) was most appropriate in the diagnosis of Helicobacterpylon (Hpylo#) infection and also to evaluate the detection of a putative virulence marker of Hpylori,the cagA. gene, by PCR in biopsy specimens.METHODS: One hundred and eighty-nine biopsy specimens were collected from 63 patients (three biopsies each) undergoing upper gastroduodenal endoscopy for various dyspeptic symptoms. The PCR methods used to detect HpylonDNA directly from biopsies were the glmM, 26-kDa,ureA and then cagA was used to compare the culturet echnique and CLO for urease with the culture technique being used as the gold standard.RESULTS: Thirty-five percent of the biopsies were positive for Hpy/or/DNA using the 3 PCR methods, while 68% of these were positive for the cagA gene. Twenty-four percent of the biopsies were negative for Hpy/or/DNA in all PCR methods screened. The remaining 41% were either positive for urea gene only, g/mMonly, 26-kDa only, or urea + g/mM,urea + 26-kDa, glmM + 26-kDa. Out of the 35% positive biopsies, 41% and 82% were positive by culture and CLO respectively, while all negative biopsies were also negative by culture and cagA. Cag A+ infection was also predominantly found in H pylori DNA of the biopsies irrespective of the clinical diagnosis.CONCLUSION: This method is useful for correctly identifying infections caused by Hpy/or/and can be easily applied in our laboratory for diagnostic purposes. | SI Smith KS Oyedeji AO Arigbabu FCantet FMegraud OOOjo AOUwaifo JAOtegbayo SOOla AO Coker | 2004 | World Journal of Gastroenterology2004，10，13： | 5 |
| 6 | A new approach to the surgical treatment of parasitic cysts of the liver:Hepatectomy using the liver hanging maneuver显示文摘AIM: To review 11 patients with parasitic cysts of the liver, who were treated by hepatic lobectomy using the liver hanging maneuver (LHM). METHODS: Between January 2003 and June 2006, we retrospectively analyzed patients who underwent surgical treatment due to parasitic cysts of the liver, at the Ege University School of Medicine, Department of General Surgery. Of these, the patients who underwent hepatic lobectomy using the LHM were reviewed and evaluated for surgical treatment outcome. RESULTS: Over a three-year period, there were 102 patients who underwent surgical treatment for parasitic cysts of the liver. Of these, 11 (10%) patients with parasitic cysts of the liver underwent hepatic lobectomy using the LHM. Presenting symptoms were abdominal pain, dyspepsia, and cholangitis. Cyst locations were as follows: right lobe filled with cyst, 7 (63%); segmental location, 2 (18%); and multiple locations, 2 patients (18%). All patients underwent hepatic lobectomy with an anterior approach using the LHM. The intraoperative blood transfusion requirement was one unit for 3 patients and two units for one patient. Postoperative complications included pulmonary atelectasy (2, 18%) and pleural effusion (2, 18%). No significant morbidity or mortality was observed. CONCLUSION: We concluded that hepatic lobectomy using the LHM should be considered, not only for hepatic tumors or donor hepatectomy, but also to treat parasitic cysts of the liver. | Aydin Unal Yazici Pinar Zeytunlu Murat Kilic Murat Coker Ahmet | 2007 | World Journal of Gastroenterology2007，13，28： | 4 |
| 7 | Laparoscopic cholecystectomy in a patient with situs inversus totalis显示文摘Currently, laparoscopic cholecystectomy is an undoubtfully optimal treatment of cholelithiasis. What about performing this procedure on a patient with situs inversus totalis and what are the difficulties of this operation for a right-handed surgeon? We presented a 35-year-old man with unknown situs inversus totalis who was admitted with epigastric pain and digestive problems. Ultrasonography and computed tomography of the abdomen confirmed the diagnosis of a gallstone. Besides, the liver and gallbladder were on the left side and the spleen was on the right. All systems were left-right reversal as mirror image in all diagnostic studies. Laparoscopic cholecystectomy was safely performed, despite of difficulties of situs inversus. The patient was discharged on postoperative day 1. It should be considered that existence of other anomalies may easily cause uninvited injuries. In the patients with situs inversus, laparoscopic cholecystectomy can be safely managed by an experienced surgeon through laparoscopy, and also hepatobiliary surgery. | Unal Aydin Omer Unalp Pinar Yazici Baris Gurcu Murat Sozbilen Ahmet Coker | 2006 | World Journal of Gastroenterology2006，12，47： | 3 |
| 8 | PRFLL– a Pinus radiata homologue of FLORICAULA and LEAFY is expressed in buds containing vegetative shoot and undifferentiated male cone primordia显示文摘 | Ewa J. Mellerowicz Kathryn Horgan Adrian Walden Astrid Coker Christian Walter | 1998 | Planta1998，，4： | 2 |
| 9 | Xanthogranulomatous pancreatitis treated by duodenum-preserving pancreatic head resection显示文摘BACKGROUND:Xanthogranulomatosis is an idiopathic,rare process in which lipid-laden histiocytes are deposited at various locations in the body.We present two cases who were treated by duodenum-preserving pancreatic head resection and eventually diagnosed as having xanthogranulomatous pancreatitis. METHODS:A 30-year-old caucasian man was admitted to our clinic for vague abdominal pain and epigastric dullness. Magnetic resonance cholangiopancreatography and endoscopic retrograde pancreatography suggested the existence of chronic pancreatitis.Another 34-year-old caucasian woman was admitted to our clinic because of right upper quadrant pain. Magnetic resonance cholangiopancreatography demonstrated a dilatation and stone of the main pancreatic duct.Based on a diagnosis of chronic pancreatitis,pancreatic head resection was planned and a laparotomy was performed in both of cases. RESULTS:In both cases,duodenum-preserving pancreatic head resection was performed.Macroscopic and microscopic findings revealed xanthogranulomatous inflammation,which led to a diagnosis of xanthogranulomatous pancreatitis. CONCLUSION:Although this type of pancreatitis is extremely rare,it is important to keep it in mind for a differential diagnosis because it may simulate chronic pancreatitis or a malignant tumor on imaging. | Alper Uguz Sava■ Yakan Baris Gurcu Funda Yilmaz Tankut Ilter Ahmet Coker | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 2 |
| 10 | Evaluation of Antioxidant Potential of Melanthera scandens显示文摘 | Sunday Adeleke Adesegun Sukurat Olasumbo Alabi Patricia Taiwo Olabanji Herbert Alexander Babatunde Coker | 2010 | Journal of Acupuncture and Meridian Studies2010，，4： | 2 |
| 11 | In-process control of surface roughness due to tool wear using a new ultrasonic system 显示文摘 | Coker S A | 1996 | Int J Mach Tools & Manuf1996，36，3： | 1 |
| 12 | Time - De- pendent Changes in Matrix Metalloproteinase acti0itg and expression during the progression of congestive heart failure: relation to ventricular and myocyte function显示文摘 | Spinale FG Coker ML Thomas CV | 1998 | Circ Res1998，82，4： | 1 |
| 13 | Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caeo-2 colon cancer cells 显示文摘 | COKER A ARISAN E D PALAVAN-UNSAL N | 2012 | Mol Med Report2012，5，4： | 1 |
| 14 | Matrix metalloproteinase inhibition during the development of congestive heart failure:effects on left ventricular dimensions and function显示文摘 | Spinale FG Coker ML Krombach SR | 1999 | Circ Res1999，85，4： | 1 |
| 15 | Determine process-pipe sizes 显示文摘 | Coker A K | 1991 | Chemical Engineering Progress1991，87，3： | 1 |
| 16 | Transforming growth factor- β1 ,-β2, and-β3, stimulate fibroblast procollagen production in vitro hut are differentially expressed during bleomycin - induced lung fibrosis显示文摘 | Coker RK Laurent GJ Shahzeidi S | 1997 | Am J Pathol1997，150，3： | 1 |
| 17 | Myocardial matrix degradation and metalloproteinase activation in the failing heart:a potential therapeutic target显示文摘 | Spinale F G Coker M L Bond B R | 2000 | Cardiovasc Res2000，46，2： | 1 |
| 18 | Biochemical characterization of a β-galactosidase with a low temperature optimum obtained from an antarctic arthrobacter isolate 显示文摘 | COKER J A SHERIDAN P P LOVELAND-CURTZE J | 2003 | Journal of Bacterology2003，185，15： | 1 |
| 19 | An association among iron, copper, zinc, and seleni- um, and antioxidative status in dyslipidemic pediatric patients with glycogen storage disease types IA and Ⅲ 显示文摘 | KALKAN-UCAR S COKER M SOZMEN E | 2010 | Journal of Trace Elements in Medicine and Biol- ogy2010，24，： | 1 |
| 20 | Pancreatic adenocarcinoma: detec tion and staging with dynamic MR imaging显示文摘 | Obuz F Dicle O Coker A | 2001 | Eur J Radiol2001，38，2： | 1 |
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