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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 3 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 4 | Structaral Models and En- dogeneity in Corporate Finance: the Link between Managerial Ownership and Corporate performance 显示文摘 | Coles J L Lemmon M L Meschre J F | 2012 | Journal of Financial Economics2012，103，1： | 1 |
| 5 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 6 | Genetic disorders of surfactant proteins显示文摘 | Hamvas A Cole F S Nogee L M | 2007 | Neonatology2007，91，4： | 1 |
| 7 | Core transcriptional regulatory circuitry in human embryonic stem cells 显示文摘 | Boyer L A Lee T I Cole M F | 2005 | Cell2005，122，6： | 1 |
| 8 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 9 | Prochloraz insensitivity in isolates of the cereal eyespot fungus, Pseudocercosporella herpotrichoides,in New Zealand显示文摘 | King A C Cole A L J Sanderson F R | 1986 | Australasian Plant Pa- thology1986，15，1： | 1 |
| 10 | Generic revision in the Holarctic ground squirrel genus Sper- mophilus 显示文摘 | HELGEN K M COLE F R HELGEN L E | 2009 | JMammal2009，90，2： | 1 |
| 11 | A theoretic perspective on postcode stress experienced by critical care nurses显示文摘 | Mastey J M Cole F L | 1992 | Heart Lung1992，21，3： | 1 |
| 12 | Non-nutritional stress acclimation of mycorrhizal woody plants exposed to drought显示文摘 | Davies F T J Svenson S E Cole C Phavaphutanon L Duray S A Olalde-Portugal V Meier C E | 1996 | Tree Physiol1996，16，11： | 1 |
| 13 | Interstate roadsides as dispersal routes for Mierotus pennsylvanicus显示文摘 | GETZ L L COLE F R GATE D L | 1978 | JMammalo1978，59，1： | 1 |
| 14 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lü uddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 15 | Expropriation Through Loan Guarantees to Related Parties: Evidence From China显示文摘 | ] Berkman H Rebel A Cole and L J F | 2006 | Journal of Banking and Finance2006，，4： | 1 |
| 16 | Ecosystem subsidies: terrestrial support of aquatic food webs from δ^13C addition to contrasting lakes显示文摘 | Carpenter S R Cole J J Pace M L Bogert M V D Bade D L Bastviken D Gille C M Hodgson J R Kitchell J F Kritzberg E S | 2005 | Ecology2005，86，： | 1 |
| 17 | Structural models and endogeneity in corporate finance: the link between managerial ownership and corporate performance 显示文摘 | Coles J L Lemmon M L Meschke J F | 2012 | Journal of Financial Economics2012，103，1： | 1 |
| 18 | Influence of oscillating dietary crude protein concen- tration on performance, acid-base balance, and nitro- gen excretion of steers 显示文摘 | COLE N A GREENE L W MCCOLLUM F T | 2003 | Journal of Animal Science2003，81，11： | 1 |
| 19 | Evidence for origin of porous silicon photoluminescence: a surface bound oxyhydride-like emitter 显示文摘 | Cole J L Dudle F P Grantier D | 1997 | Phys Rev B1997，56，： | 1 |
| 20 | Measurement of human surfactant protein-B turnover in vivo from tracheal aspirates using targeted proteomics显示文摘 | Tomazela D M Patterson B W Hanson E Spence K L Kanion T B Salinger D H Vicini P Barret H Heins H B Cole F S | | 0，，： | 1 |
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