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| 1 | Community structure and elevational diversity patterns of soil Acidobacteria显示文摘Acidobacteria is one of the most dominant and abundant phyla in soil,and was believed to have a wide range of metabolic and genetic functions. Relatively little is known about its community structure and elevational diversity patterns. We selected four elevation gradients from 1000 to 2800 m with typical vegetation types of the northern slope of Shennongjia Mountain in central China. The vegetation types were evergreen broadleaved forest,deciduous broadleaved forest,coniferous forest and sub-alpine shrubs. We analyzed the soil acidobacterial community composition,elevational patterns and the relationship between Acidobacteria subdivisions and soil enzyme activities by using the 16 S rRNA meta-sequencing technique and multivariate statistical analysis. The result found that 19 known subdivisions as well as an unclassified phylotype were presented in these forest sites,and Subdivision 6 has the highest number of detectable operational taxonomic units(OTUs). A significant single peak distribution pattern(P < 0.05) between the OTU number and the elevation was observed. The Jaccard and Bray–Curtis index analysis showed that the soil Acidobacteria compositional similarity significantly decreased(P < 0.01) with the increase in elevation distance. Mantel test analysis showed the most of the soil Acidobacteria subdivisions had the significant relationship(P < 0.01) with different soil enzymes. Therefore,soil Acidobacteria may be involved in different ecosystem functions in global elemental cycles. Partial Mantel tests and CCA analysis showed that soil pH,soil temperature and plant diversity may be the key factors in shaping the soil Acidobacterial community structure. | Yuguang Zhang Jing Cong Hui Lu Guangliang Li Yuanyuan Qu Xiujiang Su Jizhong Zhou Diqiang Li | 2014 | Journal of Environmental Sciences2014，26，8： | 17 |
| 2 | Dynamic Changes in the Wetland Landscape Pattern of the Yellow River Delta from 1976 to 2016 Based on Satellite Data显示文摘The Yellow River Delta wetland is the youngest wetland ecosystem in China's warm temperate zone. To better understand how its landscape pattern has changed over time and the underlying factors responsible, this study analyzed the dynamic changes of wetlands using five Landsat series of images, namely MSS(Mulri Spectral Scanner), TM(Thematic Mapper), and OLI(Operational Land Imager) sensors in 1976, 1986, 1996, 2006, and 2016. Object-oriented classification and the combination of spatial and spectral features and both the Normalized Difference Vegetation Index(NDVI) and Normalized Difference Water Index(NDWI), as well as brightness characteristic indices, were used to classify the images in eCognition software. Landscape pattern changes in the Yellow River Delta over the past 40 years were then delineated using transition matrix and landscape index methods. Results show that: 1) from1976 to 2016, the total area of wetlands in the study area decreased from 2594.76 to 2491.79 km^2, while that of natural wetlands decreased by 954.03 km^2 whereas human-made wetlands increased by 851.06 km^2. 2) The transformation of natural wetlands was extensive: 31.34% of those covered by Suaeda heteropteras were transformed into reservoirs and ponds, and 24.71% with Phragmites australis coverage were transformed into dry farmland. Some human-made wetlands were transformed into non-wetlands types: 1.55% of reservoirs and ponds became construction land, and likewise 21.27% were transformed into dry farmland. 3) From 1976 to 2016, as the intensity of human activities increased, the number of landscape types in the study area continuously increased. Patches were scattered and more fragmented. The whole landscape became more complex. In short, over the past 40 years, the wetlands of the Yellow River Delta have been degraded, with the area of natural wetlands substantially reduced. Human activities were the dominant forces driving these changes in the Yellow River Delta. | CONG Pifu CHEN Kexin QU Limei HAN Jianbo | 2019 | Chinese Geographical Science2019，29，3： | 12 |
| 3 | Cryopreservation of Gametophytes of Laminaria japonica (Phaeophyta) Using Encapsulation-Dehydration with Two-Step Cooling Method显示文摘Gametophytes of Laminaria japonica were cryopreserved in liquid nitrogen using encapsulation-dehydration with two-step cooling method. Gametophytes cultured at 10℃ and under continuous irradiance of 30 μmol m-2 s-1 for 3 weeks were en- capsulated in calcium alginate beads. The beads were dehydrated in 0.4 molL-1 sucrose prepared with seawater for 6 h, desiccated in an incubator set at 10℃ and 70% relative humidity for 4 h, pre-frozen at either ?40℃ or ?60℃ for 30 min, and stored in liquid nitrogen for >24 h. As high as 43% of survival rate was observed when gametophytes were thawed by placing the beads in 40℃ seawater and re-hydrated in 0.05 molL-1 citrate sodium prepared using 30‰ NaCl 7 d later. More cells of male gametophytes sur- vived the whole procedure in comparison with female gametophytes. The cells of gametophytes surviving the preservation were able to grow asexually and produce morphologically normal sporophytes. | ZHANG Quansheng CONG Yizhou QU Shancun LUO Shiju YANG Guanpin | 2008 | Journal of Ocean University of China2008，7，1： | 10 |
| 4 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 5 | 5-Ethynyl-2′-deoxyuridine as a molecular probe of cell proliferation for high-content siRNA screening assay by “click” chemistry显示文摘Labelling and identification of proliferating cells is important for the study of physiological or pathological processes in high-content screening (HCS) assays. Here we describe ethynyl deoxyuridine (EdU) as a biomarker for the assessment of cell proliferation and clearly demonstrate the feasibility of the EdU-labelling method for use in HCS assays. EdU detection is highly robust, reproducible, technically simple, and well suited for automated segmentation, which provides an excellent al- ternative for setting up multiplexed HCS assays of siRNA, miRNA and small-molecule libraries. | CHEN MiaoJuan QU DeZhong CHI WeiLin WANG Wei REN XiaoShuai CONG ShuJie LIANG PeiZhou FENG ShiPeng ZHANG BiLiang | 2011 | Science China Chemistry2011，54，11： | 6 |
| 6 | The effects of air temperature and precipitation on the net primary productivity in China during the early 21st century显示文摘Research on how terrestrial ecosystems respond to climate change can reveal the complex interactions between vegetation and climate,net primary productivity (NPP),an important vegetation parameter and ecological indicator,fluctuates within any given ecological environment or regional carbon budget.In this study, spatial interpolation was used to generate a spatial dataset, with 1-km spatial resolution,with meteorological data from 736 observation stations across China.An improved CASA model was used to simulate NPP over the period of 2001-2013 by taking into account land-cover change in every year during the same period.We propose the grid- based spatial patterns and dynamics of annual NPP,annual average temperature,and annual total precipitation based on the model.We also used the model to demonstrate the spatial correlation between NPP,temperature,and pre- cipitation in the study area with special focus on the impact of climate change in the early 21st century.Results showed that the spatial pattern of NPP over all of China is characterized by higher values in the southeast and lower values in the northwest.The spatial pattern of temperature indicates substantial latitudinal differences across the country,and the spatial pattem of precipitation shows a ribbon of decline from the southeast coast to the northwest inland.Most areas show an upward trend in NPP. Temperatures appear to decrease across the country during the global warming hiatus (1998-2008),and are accom- panied by an increase in precipitation over most regions.The correlation between NPP and annual average temperature is weak.Alternatively,NPP and annual total precipitation are positively correlated in northern and central China at a coefficient above 0.64(p <0.01)yet negatively correlated in the eastem parts of the Qinghai- Tibet Plateau and Sichuan Basin.Results can provide useful information for improving parameters for calibra- tion of the terrestrial ecosystem process model. | Qianfeng WANG Jingyu ZENG Song LENG Bingxiong FAN Jia TANG Cong JIANGs Yi HUANG Qing ZHANG Yanping QU Wnlin WANG Wei SHUI | 2018 | Frontiers of Earth Science2018，12，4： | 6 |
| 7 | Choroidal blood perfusion as a potential“rapid predictive index”for myopia development and progression显示文摘Myopia is the leading cause of visual impairment worldwide.The lack of a“rapid predictive index”for myopia development and progression hinders the clinic management and prevention of myopia.This article reviews the studies describing changes that occur in the choroid during myopia development and proposes that it is possible to detect myopia development at an earlier stage than is currently possible in a clinical setting using choroidal blood perfusion as a“rapid predictive index”of myopia. | Xiangtian Zhou Cong Ye Xiaoyan Wang Weihe Zhou Peter Reinach Jia Qu | 2021 | Eye and Vision2021，8，1： | 5 |
| 8 | Growth inhibition and apoptosis induction by alternol in pancreatic carcinoma cells显示文摘AIM: To investigate the effect of alternol on pancreatic cancer cells.METHODS: Pancreatic cancer cells PANC-1 and Bx PC3 were treated with various concentrations of alternol for 24, 48 and 72 h. Cell proliferation was measured by cell counting. Cell cycle distribution and mitochondrial membrane potential were determined by flow cytometry. Apoptosis was determined by a Td T-mediated d UTP nick end labeling assay and Hoechst staining. Expression of caspase 3, Bcl-2, p53 and p21 was measured by western blotting.RESULTS: Alternol showed dose- and time-dependent inhibition of the proliferation of PANC-1 and Bx PC3 cells in vitro. Alternol induced apoptosis and cell cycle arrest at S phase and decreased mitochondrial membrane potential. Alternol activated caspase 3, upregulated p53 and p21 expression, and downregulated Bcl-2 expression in a dose-dependent manner.CONCLUSION: Our results suggested that alternol is a candidate for treatment of pancreatic cancer. | Pei-Fang Cong Ying-Chun Qu Jie-Peng Chen Li-Li Duan Cheng-Jiang Lin Xiao-Lin Zhu Jesse Li-Ling Mei-Xia Zhang | 2015 | World Journal of Gastroenterology2015，21，15： | 4 |
| 9 | Parentage Analysis of Dongfang No.2, a Hybrid of a Female Gametophyte Clone of Laminaria japonica (Laminariales, Phaeophyta) and a Male Clone of L. longissima显示文摘The cultivation of the first filial generation of monoploid gametophyte clones of different Laminaria species (hybrid Laminaria) is an effective way of utilizing heterozygous vigor (heterosis). A female gametophyte clone of L. japonica and a male gametophyte clone of L. longissima were hybridized, generating Dongfang No.2 hybrid Laminaria. The parentage of this hybrid Laminaria was determined using AFLP of total DNA, SNP of the ITS region of ribosomal RNA transcription unit and microsatellite DNA variation at two loci. In addition to 167 AFLP bands shared by Dongfang No.2, L. japonica and L. longissima, Dongfang No.2 hybrid Laminaria shared another 70 and 55 bands with L. japonica and L. longissima, respectively, which were obviously more than 11 bands shared by L. japonica and L. longissima. Dongfang No.2 held both ‘T’ and ‘C’ at position 847 of the ITS region, while ‘T’ at this position was specific for L. japonica and ‘C’ for L. longissima, respectively. Dongfang No.2 also held the microsatellite DNA alleles of two parents together at two microsatellite DNA marker loci. These observations clearly proved that Dongfang No.2 is a true hybrid of L. japonica and L. longissiuma. Unfortunately, the origin of the chloroplast of Dongfang No.2 was not determined based on the variation of RuBisCo spacer. More sequence variants of both ITS region and RuBisCo spacer were identified in Dongfang No.2 and most of them did not exist in either L. japonica or L. longissima. The unexpected variants may be due to the mutation of ga- metophyte clones occurring during their vegetative amplification. | YANG Guanpin LIAO Meijie LI Xiaojie CONG Yizhou QU Shancun WANG Tongyong | 2008 | Journal of Ocean University of China2008，7，2： | 4 |
| 10 | Machine-learning-assisted prediction of the mechanical properties of Cu–Al alloy显示文摘The machine-learning approach was investigated to predict the mechanical properties of Cu–Al alloys manufactured using the powder metallurgy technique to increase the rate of fabrication and characterization of new materials and provide physical insights into their properties.Six algorithms were used to construct the prediction models, with chemical composition and porosity of the compacts chosen as the descriptors.The results show that the sequential minimal optimization algorithm for support vector regression with a puk kernel(SMOreg/puk) model demonstrated the best prediction ability. Specifically, its predictions exhibited the highest correlation coefficient and lowest error among the predictions of the six models. The SMOreg/puk model was subsequently applied to predict the tensile strength and hardness of Cu–Al alloys and provide guidance for composition design to achieve the expected values. With the guidance of the SMOreg/puk model, Cu–12Al–6Ni alloy with a tensile strength(390 MPa) and hardness(HB 139) that reached the expected values was developed. | Zheng-hua Deng Hai-qing Yin Xue Jiang Cong Zhang Guo-fei Zhang Bin Xu Guo-qiang Yang Tong Zhang Mao Wu Xuan-hui Qu | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，3： | 4 |
| 11 | Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population显示文摘TP53,一个 transcriptional 管理者和肿瘤 suppressor,在精子发生是机能上地重要的。MDM2 是 p53 小径的一个关键管理者并且调制 p53 活动。两蛋白质机能上地被连接了到细菌房间 apoptosis,它可以影响人的不孕,但是几乎不在在这些基因的普通多型性怎么可以影响细菌房间 apoptosis 和男不孕的风险上被知道。因此,这研究被设计测试三是否以前描述了多型性 72Arg >专业版(rs1042522 ) 和 Ex2+ 19C >在 TP53 的 T (rs2287498 ) ,和 5 ′untranslated 区域(5 ′UTR ) 309T >在 MDM2 的 G (rs937283 ) ,在一张中国人口与自发的男不孕被联系。三多型性是用在基于医院的盒子控制研究的 OpenArray 试金的 genotyped,包括 580 个不肥沃的病人和 580 肥沃的控制。我们的分析揭示了那 TP53 Ex2+ 19C > T 和 MDM2 309T > G 多型性与男不孕被联系。而且,我们为男不孕的发展检测了在 TP53 rs2287498 和 MDM2 rs937283 之间的一个将近统计上重要的添加剂相互作用(P 相互作用 =0.055) 。在摘要,这研究发现了初步的证据,证明在 TP53 小径的基因的基因变体是为男不孕的风险因素。 | Cong Huang Wei Liu Gui-Xiang Ji Ai-Hua Gu Jian-Hua Qu Ling Song Xin-Ru Wang | 2012 | Asian Journal of Andrology2012，14，5： | 4 |
| 12 | Fungus induces the release of IL- 8 in human corneal epithelial cells, via Dectin-1-mediated protein kinase C pathways显示文摘AIM: To identify whether Aspergillus fumigatus(A.fumigatus) hyphae antigens induced the release of interleukin-8(IL-8) in anti-fungal innate immunity of cultured human corneal epithelial cells(HCECs) and determine the involvement of intracellular signalling pathways. METHODS: HCECs were treated with A. fumigatus hyphae antigens with different concentrations and time.The cytoplasmic calcium of HCECs were assessed by fluorescence imaging. Western blot was used to detect the expression of Ca2 +-dependent protein kinase C(PKC). The IL-8 levels were determined by specific human IL-8 enzyme-linked immunosorbent assay(ELISA) and reverse transcriptase polymerase chain reaction(RT-PCR). Using a series of pharmacological inhibitors, we examined the upstream signalling pathway responsible for IL-8 expression in response to A.fumigatus hyphae antigens. RESULTS: Cells exposed to A. fumigatus hyphae antigens showed higher level of IL-8 m RNA expression and protein production. We demonstrated here that stimulation of HCECs with A. fumigatus hyphae triggers an intracellular Ca2 +flux and results in the activation of Ca2 +-dependent PKC(α, βⅠ and βⅡ) which can be attenuated by pre-treatment of cells with laminarin,suggesting that Dectin-1 signals pathway induced cytoplasmic calcium and influence the activation of PKC in HCECs. Inhibitors of Ca2 +-dependent PKC(Ro-31-8220 and Go6976) significantly abolished hyphae-induced expression of IL-8.CONCLUSION: Our findings suggest that A. fumigatushyphae-induced IL-8 expression was regulated by the activation of Dectin-1-mediated Ca2 +-dependent PKC in HCECs. | Xu-Dong Peng Gui-Qiu Zhao Jing Lin Nan Jiang Qiang Xu Cheng-Cheng Zhu Jian-Qiu Qu Lin Cong Hui Li | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 4 |
| 13 | Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza显示文摘Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this winter.However,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear.Using a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following H1N1.We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets.Moreover,mortality was increased in sequentially infected mice compared with single-infection mice.Compared with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.Combined immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 infection.Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter. | Linlin Bao Wei Deng Feifei Qi Qi Lv Zhiqi Song Jiangning Liu Hong Gao Qiang Wei Pin Yu Yanfeng Xu Yajin Qu Fengdi Li Jing Xue Shuran Gong Mingya Liu Guanpeng Wang Shunyi Wang Binbin Zhao Bin Cong Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 4 |
| 14 | Utility of Droplet Digital PCR Assay for Quantitative Detection of Norovirus in Shellfish, from Production to Consumption in Guangxi, China显示文摘Objective Shellfish are recognized as important vehicles of norovirus-associated gastroenteritis. The present study aimed to monitor norovirus contamination in oysters along the farm-to-fork continuum in Guangxi, a major oyster production area in Southwestern China. Methods Oyster samples were collected monthly from farms, markets, and restaurants, from January to December 2016. Norovirus was detected and quantified by one-step reverse transcription-droplet digital polymerase chain reaction(RT-ddPCR). Results A total of 480 oyster samples were collected and tested for norovirus genogroups I and II. Norovirus was detected in 20.7% of samples, with genogroup II predominating. No significant difference was observed in norovirus prevalence among different sampling sites. The norovirus levels varied widely, with a geometric mean of 19,300 copies/g in digestive glands. Both norovirus prevalence and viral loads showed obvious seasonality, with a strong winter bias. Conclusion This study provides a systematic analysis of norovirus contamination ‘from the farm to the fork' in Guangxi. RT-ddPCR can be a useful tool for detection and quantification of low amounts of norovirus in the presence of inhibitors found particularly in foodstuffs. This approach will contribute to the development of strategies for controlling and reducing the risk of human illness resulting from shellfish consumption. | TAN Dong Mei LYU Su Ling LIU Wei ZENG Xian Ying LAN Lan QU Cong ZHUGE Shi Yang ZHONG Yan Xu XIE Yi Hong LI Xiu Gui | 2018 | Biomedical and Environmental Sciences2018，31，10： | 4 |
| 15 | Dissection of the genetic architecture for tassel branch number by QTL analysis in two related populations in maize显示文摘Tassel branch number(TBN) is the principal component of maize tassel inflorescence architecture and is a typical quantitative trait controlled by multiple genes. The main objective of this research was to detect quantitative trait loci(QTLs) for TBN. The maize inbred line SICAU1212 was used as the common parent to develop BC1S1 and recombinant inbred line(RIL) populations with inbred lines 3237 and B73, respectively. The two related populations consisted of 123 and 238 lines, respectively. Each population was grown and phenotyped for TBN in two environments. Eleven QTLs were detected in the BC1S1 population, located on chromosomes 2, 3, 5, and 7, accounted for 4.45–26.58% of the phenotypic variation. Two QTLs(qB11Jtbn2-1, qB12Ctbn2-1, qBJtbn2-1; q11JBtbn5-1, qB12Ctbn5-1, qBJtbn5-1) that accounted for more than 10% of the phenotypic variation were identified. Three QTLs located on chromosomes 2, 3 and 5, exhibited stable expression in the two environments. Ten QTLs were detected in the RIL population, located on chromosomes 2, 3, 5, 8, and 10, accounted for 2.69–13.58% of the TBN variation. One QTL(qR14Dtbn2-2) explained >10% of the phenotypic variation. One common QTL(qB12Ctbn2-2, qR14Dtbn2-2, q RJtbn2-2) was detected between the two related populations. Three pairs of epistatic effects were identified between two loci with or without additive effects and accounted for 1.19–4.26% of the phenotypic variance. These results demonstrated that TBN variation was mainly caused by major effects, minor effects and slightly modified by epistatic effects. Thus, identification of QTL for TBN may help elucidate the genetic basis of TBN and also facilitate map-based cloning and marker-assisted selection(MAS) in maize breeding programs. | CHEN Zheng-jie YANG Cong TANG Deng-guo ZHANG Lei ZHANG Ling QU Jing-tao LIU Jian | 2017 | Journal of Integrative Agriculture2017，16，7： | 4 |
| 16 | miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer显示文摘 | Bi-Lan Li Cong Lu Wen Lu Ting-ting Yang Junjie Qu Xiayu Hong Xiao-ping Wan | 2013 | Medical Oncology2013，，1： | 3 |
| 17 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 18 | Ultra-small hollow ternary alloy nanoparticles for efficient hydrogen evolution reaction显示文摘Hollow nanoparticles with large specific surface area and high atom utilization are promising catalysts for the hydrogen evolution reaction(HER). We describe herein the design and synthesis of a series of ultra-small hollow ternary alloy nanostructures using a simple one-pot strategy. The same technique was demonstrated for hollow PtNiCu nanoparticles, hollow PtCoCu nanoparticles and hollow CuNiCo nanoparticles. During synthesis, the displacement reaction and oxidative etching played important roles in the formation of hollow structures. Moreover, our hollow PtNiCu and PtCoCu nanoparticles were single crystalline, with an average diameter of 5 nm. Impressively, ultra-small hollow PtNiCu nanoparticles,containing only 10% Pt, exhibited greater electrocatalytic HER activity and stability than a commercial Pt/C catalyst. The overpotential of hollow Pt Ni Cu nanoparticles at 10 mA cm^(-2) was 28 mV versus reversible hydrogen electrode(RHE). The mass activity was 4.54 A mg Pt^(-1) at-70 mV versus RHE, which is 5.62-fold greater than that of a commercial Pt/C system(0.81 A mg Pt^(-1)). Through analyses of bonding and antibonding orbital filling, density functional theory calculations demonstrated that the bonding strength of different metals to the hydrogen intermediate(H*) was in the order of Pt > Co > Ni > Cu. The excellent HER performance of our hollow PtNiCu nanoparticles derives from moderately synergistic interactions between the three metals and H*. This work demonstrates a new strategy for the design of low-cost and high-activity HER catalysts. | Zhenxing Li Chengcheng Yu Yikun Kang Xin Zhang Yangyang Wen Zhao-Kui Wang Chang Ma Cong Wang Kaiwen Wang Xianlin Qu Miao He Ya-Wen Zhang Weiyu Song | 2021 | National Science Review2021，8，7： | 2 |
| 19 | Genome assembly of the maize inbred line A188 provides a new reference genome for functional genomics显示文摘The current assembled maize genomes cannot represent the broad genetic diversity of maize germplasms.Acquiring more genome sequences is critical for constructing a pan-genome and elucidating the linkage between genotype and phenotype in maize.Here we describe the genome sequence and annotation of A188,a maize inbred line with high phenotypic variation relative to other lines,acquired by single-molecule sequencing and optical genome mapping.We assembled a 2210-Mb genome with a scaffold N50 size of 11.61 million bases(Mb),compared to 9.73 Mb for B73 and 10.2 Mb for Mo17.Based on the B73_Ref Gen_V4 genome,295 scaffolds(2084.35 Mb,94.30%of the final genome assembly)were anchored and oriented on ten chromosomes.Comparative analysis revealed that~30%of the predicted A188 genes showed large structural divergence from B73,Mo17,and W22 genomes,which causes high protein divergence and may lead to phenotypic variation among the four inbred lines.As a line with high embryonic callus(EC)induction capacity,A188 provides a convenient tool for elucidating the molecular mechanism underlying the formation of EC in maize.Combining our new A188 genome with previously reported QTL and RNA sequencing data revealed eight genes with large structural variation and two differentially expressed genes playing potential roles in maize EC induction. | Fei Ge Jingtao Qu Peng Liu Lang Pan Chaoying Zou Guangsheng Yuan Cong Yang Guangtang Pan Jianwei Huang Langlang Ma Yaou Shen | 2022 | The Crop Journal2022，10，1： | 2 |
| 20 | A mumps model with seasonality in China显示文摘Background:Mumps,an infectious viral disease,classically manifested by inflammation of salivary glands and is best known as a common childhood viral disease with no specific treatment.Although it can be protected by vaccine,there are more than 100,000 reported mumps cases according to the Chinese Center for Disease Control and Prevention.However,the factors and mechanisms behind the persistence and prevalence of mumps have not been well understood.Methods:A mumps model with seasonal fluctuation is formulated and investigated.We evaluate the basic reproduction numberℛ0 and analyze the dynamical behavior of the model.We also use the model to simulate the monthly data of mumps cases and carry out some sensitivity analysis ofℛ0 in terms of various model parameters.Results:It is shown that there exists only disease-free solution which is globally asymptotically stable ifℛ0<1,and there exists a positive periodic solution ifℛ0>1.ℛ0 is a threshold parameter,and its magnitude determines the extinction or persistence of the disease.Conclusion:Our analysis shows that vaccination rate and invalid vaccination rate play important roles in the spread of mumps.Hence,Our study suggests to increase the vaccine coverage and make two doses of MMR(Measles,mumps and rubella vaccine)vaccine freely available in China. | Qianqian Qu Cong Fang Le Zhang Wanru Jia Jie Weng Yong Li | 2017 | Infectious Disease Modelling2017，2，1： | 2 |
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