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您的检索式：作者名="Congmei Chen"
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| 1 | Gut microbiota,inflammation,and molecular signatures of host response to infection显示文摘Gut microbial dysbiosis has been linked to many noncommunicable diseases.However,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to infection.Here,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the COVID-19.We demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,individuals.We further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 individuals.Fecal metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and inflammation.Overall,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy individuals.These results may provide novel insights into the cross-talk between gut microbiota and host immune system. | Wanglong Gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai Menglei Shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang Zelei Miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao Wenhua Ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng | 2021 | Journal of Genetics and Genomics2021，48，9： | 1 |
| 2 | Facile one-pot synthesis of superfine palladium nanoparticles on polydopamine-functionalized carbon nanotubes as a nanocatalyst for the Heck reaction显示文摘Heterogeneous Pd nanocatalysts are efficient catalysts for the Heck reaction but require multi-step,sophisticated procedures and harsh reaction conditions.In this work,a green and facile strategy has been developed to decorate Pd nanoparticles on polydopamine(PDA)-coated multi-walled carbon nanotubes(Pd/CNTs-PDA)via a one-pot method.The obtained nanoparticles were characterized by various techniques including transmission electron microscopy,X-ray diffraction,and X-ray photoelectron spectroscopy,which proved that Pd NPs are well-dispersed on the PDA and between the surfaces of the PDA and CNTs.The resultant Pd/CNTs-PDA catalysts exhibit excellent catalytic reactivity toward the Heck reaction at low temperatures.Moreover,by DFT simulation,we found that during the PDA polymerization process,a large number of unsaturated—N=and C=O species are more active than the groups on the PDA end product to anchor Pd NPs.The results provide evidence that the catalyst synthesized by the onepot method exhibited good activity because sufficient active sites could be created to effectively promote Pd NPs dispersion during the dopamine polymerization process.Additionally,the Pd/CNTs-PDA catalyst was successfully employed in Heck cross-coupling reactions with various functionalized substrates.This method opens a window for the fabrication of high-performance nanocomposite catalysts under mild conditions using simple methods and has several potential applications. | Zhengxiu Luo Ning Wang Xiaoyan Pei Tao Dai Zhigang Zhao Congmei Chen Maofei Ran Wenjing Sun | 2021 | Journal of Materials Science & Technology2021，，23： | 0 |
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