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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Numerical Simulation and Analysis of Solid-liquid Two-phase Flow in Centrifugal Pump显示文摘The flow with solid-liquid two-phase media inside centrifugal pumps is very complicated and the relevant method for the hydraulic design is still immature so far.There exist two main problems in the operation of the two-phase flow pumps,i.e.,low overall efficiency and severe abrasion.In this study,the three-dimensional,steady,incompressible,and turbulent solid-liquid two-phase flows in a low-specific-speed centrifugal pump are numerically simulated and analyzed by using a computational fluid dynamics(CFD) code based on the mixture model of the two-phase flow and the RNG k-two-equation turbulence model,in which the influences of rotation and curvature are fully taken into account.The coupling between impeller and volute is implemented by means of the frozen rotor method.The simulation results predicted indicate that the solid phase properties in two-phase flow,especially the concentration,the particle diameter and the density,have strong effects on the hydraulic performance of the pump.Both the pump head and the efficiency are reduced with increasing particle diameter or concentration.However,the effect of particle density on the performance is relatively minor.An obvious jet-wake flow structure is presented near the volute tongue and becomes more remarkable with increasing solid phase concentration.The suction side of the blade is subject to much more severe abrasion than the pressure side.The obtained results preliminarily reveal the characteristics of solid-liquid two-phase flow in the centrifugal pump,and are helpful for improvement and empirical correction in the hydraulic design of centrifugal pumps. | ZHANG Yuliang LI Yi CUI Baoling ZHU Zuchao DOU Huashu | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 55 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 5 | Review on utilization of biochar for metal-contaminated soil and sediment remediation显示文摘Biochar is a carbon-neutral or even carbon-negative material produced through thermal decomposition of plant-and animal-based biomass under oxygen-limited conditions.Recently, there has been an increasing interest in the application of biochar as an adsorbent, soil ameliorant and climate mitigation approach in many types of applications.Metal-contaminated soil remediation using biochar has been intensively investigated in small-scale and pilot-scale trials with obtained beneficial results and multifaceted effects.But so far, the study and application of biochar in contaminated sediment management has been very limited, and this is also a worldwide problem. Nonetheless, there is reason to believe that the same multiple benefits can also be realized with these sediments due to similar mechanisms for stabilizing contaminants. This paper provides a review on current biochar properties and its use as a sorbent/amendment for metal-contaminated soil/sediment remediation and its effect on plant growth, fauna habits as well as microorganism communities. In addition, the use of biochar as a potential strategy for contaminated sediment management is also discussed, especially as regards in-situ planning. Finally, we highlight the possibility of biochar application as an effective amendment and propose further research directions to ensure the safe and sustainable use of biochar as an amendment for remediation of contaminated soil and sediment. | Mingming Wang Yi Zhu Lirong Cheng Bruce Andserson Xiaohui Zhao Dayang Wang Aizhong Ding | 2018 | Journal of Environmental Sciences2018，30，1： | 43 |
| 6 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 7 | Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK显示文摘Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia(T-ALL) cells and potential molecular mechanisms. Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. Western blotting was performed for detecting changes of apoptosis-associated proteins, cell cycle regulatory proteins and state of activation of Akt, mTOR, p70S6K, 4E-BP1, and p38-MAPK. Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase(CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. Western blotting revealed that resveratrol significantly decreased the expression of antiapoptotic proteins(Mcl-1 and Bcl-2) and increased the expression of proapoptotic proteins(Bax, Bim, and Bad), and induced cleaved-caspase-3 in a time-dependent manner. Significant increase in ratio of LC3-II/LC3-I and Beclin 1 was also detected. Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced.Conclusion Our findings have suggested that resveratrol induces cell cycle arrest,apoptosis,and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways.Autophagy might play a role as a self-defense mechanism in T-ALL cells treated by resveratrol.Therefore,the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. | GE Jiao LIU Yan LI Qiang GUO Xia GU Ling MA Zhi Gui ZHU Yi Ping | 2013 | Biomedical and Environmental Sciences2013，26，11： | 38 |
| 8 | Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer:the FUTURE trial显示文摘Triple-negative breast cancer(TNBC)is a highly heterogeneous disease,and molecular subtyping may result in improved diagnostic precision and targeted therapies.Our previous study classified TNBCs into four subtypes with putative therapeutic targets.Here,we conducted the FUTURE trial(ClinicalTrials.gov identifer:NCT03805399),a phaseⅠb/Ⅱsubtyping-based and genomic biomarker-guided umbrella trial,to evaluate the efficacy of these targets.Patients with refractory metastatic TNBC were enrolled and stratifed by TNBC subtypes and genomic biomarkers,and assigned to one of these seven arms:(A)pyrotinib with capecitabine,(B)androgen receptor inhibitor with CDK4/6 inhibitor,(C)anti PD-1 with nab-paclitaxel,(D)PARP inhibitor included,(E)and(F)anti-VEGFR included,or(G)mTOR inhibitor with nab paclitaxel.The primary end point was the objective response rate(ORR).We enrolled 69 refractory metastatic TNBC patients with a median of three previous lines of therapy(range,1-8).Objective response was achieved in 20(29.0%,95%confidence interval(CI):18.7%-41.2%)of the 69 intention-to-treat(ITT)patients.Our results showed that immunotherapy(arm C),in particular,achieved the highest ORR(52.6%,95%CI:28.9%-75.6%)in the ITT population.Arm E demonstrated favorable ORR(26.1%,95%C:10.2%-48.4%in the ITT population)but with more high grade(23)adverse events.Somatic mutations of TOP2A and CD8 immunohistochemical score may have the potential to predict immunotherapy response in the immunomodulatory subtype of TNBC.In conclusion,the phaseⅠb/ⅡFUTURE trial suggested a new concept for TNBC treatment,demonstrating the clinical beneft of subtyping-based targeted therapy for refractory metastatic TNBC. | Yi-Zhou Jiang Yin Liu Yi Xiao Xin Hu Lin Jiang Wen-ia Zuo Ding Ma Jiahan Ding Xiaoyu Zhu Jianjun Zou Claire Verschraegen Daniel G.Stover Virginia Kaklamani Zhong-Hua Wang Zhi-Ming Shao | 2021 | Cell Research2021，31，2： | 37 |
| 9 | Study of time-domain digital pulse shaping algorithms for nuclear signals显示文摘With the development on high-speed integrated circuit,fast high resolution sampling ADC and digital signal processors are replacing analog shaping amplifier circuit.This paper firstly presents the numerical analysis and simulation on R-C shaping circuit model and C-R shaping circuit model.Mathematic models are established based on 1st order digital differential method and Kirchhoff Current Law in time domain,and a simulation and error evaluation experiment on an ideal digital signal are carried out with Excel VBA.A digital shaping test for a semiconductor X-ray detector in real time is also presented.Then a numerical analysis for Sallen-Key(S-K) low-pass filter circuit model is implemented based on the analysis of digital R-C and digital C-R shaping methods.By applying the 2nd order non-homogeneous differential equation,the authors implement a digital Gaussian filter model for a standard exponential-decaying signal and a nuclear pulse signal.Finally,computer simulations and experimental tests are carried out and the results show the possibility of the digital pulse processing algorithms. | ZHOU Jianbin ZHOU Wei LEI Jiarong TUO Xianguo ZHU Xing LIU Yi | 2012 | Nuclear Science and Techniques2012，23，3： | 34 |
| 10 | A Mini-Review on Metal Recycling from Spent Lithium Ion Batteries显示文摘 | Xiaohong Zheng Zewen Zhu Xiao Lin Yi Zhang Yi He Hongbin Cao Zhi Sun | 2018 | Engineering2018，4，3： | 33 |
| 11 | Wet Cupping Therapy Improves Local Blood Perfusion and Analgesic Effects in Patients with Nerve-Root Type Cervical Spondylosis显示文摘Objective: To observe wet cupping therapy(WCT) on local blood perfusion and analgesic effects in patients with nerve-root type cervical spondylosis(NT-CS). Methods: Fifty-seven NT-CS patients were randomly divided into WCT group and Jiaji acupoint-acupuncture(JA) group according a random number table. WCT group(30 cases) was treated with WCT for 10 min, and JA group(27 cases) was treated with acupuncture for 10 min. The treatment efficacies were evaluated with a Visual Analogue Scale(VAS). Blood perfusion at Dazhui(GV 14) and Jianjing(GB 21) acupoints(affected side) was observed with a laser speckle flowmetry, and its variations before and after treatment in both groups were compared as well. Results: In both groups, the VAS scores significantly decreased after the intervention(P<0.01), while the blood perfusion at the two acupoints significantly increased after intervention(P<0.05); however, the increasement magnitude caused by WCT was obvious compared with JA(P<0.05). Conclusion: WCT could improve analgesic effects in patients with NT-CS, which might be related to increasing local blood perfusion of acupunct points. | MENG Xiang-wen WANG Ying PIAO Sheng-ai LV Wen-tao ZHU Cheng-hui MU Ming-yuan LI Dan-dan LIU Hua-peng GUO Yi | 2018 | Chinese Journal of Integrative Medicine2018，24，11： | 33 |
| 12 | Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma:Comparison with conventional diffusion-weighted imaging显示文摘AIM To compare intravoxel incoherent motion(IVIM)-derived parameters with conventional diffusion-weighted imaging(DWI) parameters in predicting the histological grade of hepatocellular carcinoma(h CC) and to evaluate the correlation between the parameters and the histological grades.METHODS A retrospective study was performed. Sixty-two patients with surgically confirmed h CCs underwent diffusion-weighted magnetic resonance imaging with twelve b values(10-1200 s/mm^2). The apparent diffusion coefficient(ADC), pure diffusion coefficient(D), pseudo-diffusion coefficient(D*), and perfusion fraction(f) were calculated by two radiologists. The IVIM and conventional DWI parameters were compared among the different grades by using analysis of variance(ANOVA) and the Kruskal-Wallis test. Receiver operating characteristic(ROC) analysis was performed to evaluate the diagnostic efficiency of distinguishing between low-grade(grade 1, G1) and high-grade(grades 2 and 3, G2 and G3) hC C. The correlation between the parameters and the histological grades was assessed by using the Spearman correlation test. Bland-Altman analysis was used to evaluate the reproducibility of the two radiologists' measurements.RESULTS The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of HCCs were statistically significant(P < 0.001). The D* and f values had no significant differences among the different histological grades of h CC(P > 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performance in differentiating the low-grade h CC from the high-grade h CC, with areas under the curve(AUCs) of 0.909 and 0.843, respectively, measured by radiologist 1 and of 0.911 and 0.852, respectively, measured by radiologist 2. The following significant correlations were obtained between the ADC, D, and D~* values and the histological grades: r =-0.619(P < 0.001), r =-0.628(P < 0.001), and r =-0.299(P = 0.018), respectively, as measured by radiologist 1; r =-0.622(P < 0.001), r =-0.633(P < 0.001), and r =-0.303(P = 0.017), respectively, as measured by radiologist 2. The intra-class correlation coefficient(ICC) values between the two observers were 0.996 for ADC, 0.997 for D, 0.996 for D*, and 0.992 for f values, which indicated excellent interobserver agreement in the measurements between the two observers.CONCLUSION The IVIM-derived D and ADC values show better diagnostic performance in differentiating high-grade hC C from low-grade hC C, and there is a moderate to good correlation between the ADC and D values and the histological grades. | Shao-Cheng Zhu Yue-Hua Liu Yi Wei Lin-Lin Li She-Wei Dou Ting-Yi Sun Da-Peng Shi | 2018 | World Journal of Gastroenterology2018，24，8： | 33 |
| 13 | Prevalence of osteoporotic vertebral fracture among community-dwelling elderly in Shanghai显示文摘To the Editor:Osteoporosis is becoming a common,serious,and costly health problem,which causes over nine million fractures annually worldwide.[1] Currently,osteoporotic fractures are a considerable burden to public health services and have fairly high morbidity and mortality.[2] Vertebral fractures are the most common osteoporotic fracture and may lead to a high risk of further fracture and could be prevalent in both females and males.[3] Ling et al[4] and Ms.OS studies[5] evaluated the prevalence of vertebral fractures in Beijing and Hong Kong,respectively.However,our knowledge of the descriptive epidemiology and risk factors for vertebral fracture in China still remains poor. | Chao Gao Yang Xu Li Li Wen-Qin Gu Chun-Tao Yi Qiong Zhu Hong-An Gu Bi-Hua Chen Qing-Qing Wang Feng Tang Ju-Liang Xu Jian-Miao Hou Hui-Jiang Song Hui Wang Zhi-Liang Wang Zhen-Lin Zhang | 2019 | Chinese Medical Journal2019，，14： | 31 |
| 14 | Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer显示文摘背景分子的指向的药现在广泛地在临床的 treatment.lcotinib hydrochloride 是的非小的房间肺癌症(NSCLC ) 被使用口头的表皮的生长的一种新类型因素受体(EGFR ) tyresine kinase 禁止者(EGFR-TKIs ) 。在这研究,我们作为我们分析了的 icotinib hydrochlodde.Methods 的功效的 predicators 从先进 NSCLC 病人在肿瘤标本检验了 EGFR ,K地岬,B皇家空军体的变化和 EGFR mRNAexpression 的角色肿瘤嵌入石蜡的标本,它与先进 NSCLC 从 40 个病人中的 14 个被获得在阶段注册了 icotinib hydrochloride 的临床的试用。体的变化被充实异种的 liquidchip (MEL ) 评估技术,和 EGFR mRNA 表示被分叉的 DNA liquidchip (MBL ) 测量在 14 个标本的 technology.Results,七个病人显示出 EGFR 变化, exon 19 删除(3/7 ) 和 exon 21 点变化(4/7 ) ;并且二个病人显示出 K 地岬变化。在 EGFR exon 的没有变化 20。或 B 皇家空军被检测。在有 EGFR 变化的病人,一个病人得了进步疾病(PD ) ,三个病人有稳定的疾病(SD ) ,二个病人有部分回答(PR ) ,一个病人有完全的回答(CR ) 。在有野类型的 EGFR 的病人,四个病人有 PD,三个病人获得了 SD,并且任何一个都没有 PR/CR (P=0.0407 ) 。EGFR 变化与更好没有进步的幸存(PFS )(141 天对 61 天) ,但是没有统计上重要的差别(P=0.8597 ) 被联系,并且中部的全面幸存(OS )(449 天对 140 天) 。 EGFR mRNA 表示层次被评估(三高度,八中等,一个低,并且二那不能由于不够的肿瘤织物被测量)并且没有统计上重要的关系与 EGFR 变化率是的反应, PFS 或 OS.Conclusions 被观察与在亚洲人口报导了那一致, MEL 技术因此为与高产量和快测量 EGFR 变化是可靠的。EGFR exon 19 删除和 exon 21 点变化作为第二线治疗以上是为对 icotinib hydrochloride 的反应的预兆的 biomarkers。 | REN Guan-jun ZHAO Yuan-yua ZHU Yu-jia XIAO Yi XU Jia-sen SHAN Bin ZHANG Li | 2011 | Chinese Medical Journal2011，，1： | 30 |
| 15 | ABF2, ABF3, and ABF4 Promote ABA-Mediated Chlorophyll Degradation and Leaf Senescence by Transcriptional Activation of Chlorophyll Catabolic Genes and Senescence-Associated Genes in Arabidopsis显示文摘叶绿素(Chl ) 降级是叶老朽的一个不可分的过程,并且 NYE1/SGR1 在多样的工厂种类作为 Chl 分解代谢的一个关键管理者被表明了。在这研究,用屏蔽的酵母一个混血儿,我们识别了三 abscisic 酸(骆驼毛的织物) 应答的元素(ABRE ) 绑定抄写因素, ABF2 (AREB1 ) , ABF3,和 ABF4 (AREB2 ) , NYE1 倡导者的通常认为的有约束力的蛋白质。通过 transactivation 分析, electrophoretic 活动性移动试金,和染色质 immunoprecipitation,我们表明了直接跳到并且在 vitro 并且在 vivo 激活 NYE1 倡导者的那 ABF2, ABF3,和 ABF4。骆驼毛的织物是叶老朽的一个积极管理者,并且外长地适用骆驼毛的织物能加速 Chl 降级。ABF, abf2abf3abf4,以及二骆驼毛的织物感觉迟钝的异种, abi1-1 和 snrk2.2/2.3/2.6 的三倍的异种,在骆驼毛的织物处理以后的展出停留绿色显型,与 NYE1 和 NYE2 表示的减少的正式就职一起。相反, ABF4 的 overexpression 在骆驼毛的织物处理之上加速了 Chl 降级。有趣地, ABF2/3/4 能也激活二 Chl 分解代谢的酶基因, PAO 和 NYC1 的表达式,由对他们的倡导者直接有约束力。另外, abf2abf3abf4 展出了功能的停留绿色显型,和联系老朽的基因(下垂) 例如 SAG29 (SWEET15 ) ,可能被 ABF 直接调整。一起拿,我们的结果在调停作为关键管理者建议那 ABF2, ABF3,和 ABF4 可能的行为被触发骆驼毛的织物的 Chl 降级和叶老朽一般来说在 Arabidopsis。 | Shan Gao Jiong Gao Xiaoyu Zhu Yi Song Zhongpeng Li Guodong Ren Xin Zhou Benke Kuai | 2016 | Molecular Plant2016，9，9： | 27 |
| 16 | Nutritional and medicinal characteristics of Chinese giant salamander (Andrias davidianus) for applications in healthcare industry by artificial cultivation: A review显示文摘Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with extinction in the past decades due to over capturing,deterioration of natural environment,the slow breeding and growth of the wild species in nature.However,in the past twenty years,with the breakthrough and progress of artificial breeding technology by artificial insemination,the number of artificially cultivated CGS has increased rapidly.Artificially cultivated CGS can either be released to the CGS living environment to increase the population in nature or legally applied in food and medicinal industry as a feedstock due to the unique nutritional and medicinal values of CGS as recorded historically.In this review,the nutritional components,bioactive components and medicinal activities of the artificially cultivated CGS will be summarized.The mucus,skin,meat and bone of CGS contain many different bioactive substances thereby having various medicinal activities including anti-aging,anti-fatigue,anti-tumor,therapy of burn and anti-infection and other physiological functions.This paper will further discuss the potential applications of the artificially cultivated CGS in healthcare industry and prospects of future technological development. | Dong He Wenming Zhu Wen Zenga Jun Lin Yang Ji Yi Wang Chong Zhang Yuan Lu Daoquan Zhao Nan Su Xin-Hui Xing | 2018 | Food Science and Human Wellness2018，7，1： | 28 |
| 17 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 18 | CD44v6 in peripheral blood and bone marrow of patients with gastric cancer as micro-metastasis显示文摘瞄准:为了检测 CD44 的表示,与能力相关在有胃的癌症并且到的病人的外部血和骨髓微转移推出它的临床的意义。方法:从有胃的癌症和 6 控制的 46 个病人的外科手术前的外部血和骨髓标本被 CD44v6mRNA 的半量的 RT-PCR 扩大学习。从有胃的癌症和 14 控制的 40 个病人的外科手术前、手术后的外部血标本被 CD44v6mRNA 的量的 RT-PCR 扩大在相应经期学习。结果:半量的 RT-PCR 扩大证明外部血和骨髓的那 CD44v6mRNA 表情在 39 是积极的(84.8%) 并且 40 (86.9%) 有胃的癌症的 46 个病人分别地。在外部血, CD44v6mRNA 表示为 diffuse 是积极的 32 个病人并且为 14 个病人的在 9 的肠的类型(64.3%) 的在 30 的类型(93.8%) 。在另一方面在骨髓, CD44v6mRNA 表示为 diffuse 是积极的 32 个病人并且为 14 个病人的在 10 的肠的类型(71.4%) 的在 31 的类型(96.9%) 。在弥漫的类型和肠的类型之间有有效差量。量的 RT-PCR 扩大证明 CD44v6mRNA 没在控制的外部血被表示, CD44v6mRNA 表示为在有胃的癌症的 40 个病人的外科手术前的外部血是积极的,从 4.9 x 10 的表示层次(8 )- 3.2 x 10 (11 ) copies/g RNA。在外部血的 CD44v6mRNA 的平均表示水平是 3.9 x 10 (10 ) copies/g RNA。在在在到 7.6 x 10 的从 5.5 x 10 增加的药品操作(6 )(9 ) 以后的胃的癌症病人的外部血的 CD44v6mRNA 的表示层次 copies/g RNA 和平均水平是 2.4 x 10 (8 ) copies/g RNA (图 3B )(P = 0.00496 ) 。在药品操作以后,表示水平显著地减少了。结论:为 CD44v6mRNA 的半量、量的 RT-PCR 扩大是为察觉的一个敏感、特定的方法在外部血和骨髓微转移,它可能被用作肿瘤负担和治疗学的效果的指示物。 | Dao-Rong Wang Guo-Yu Chen Xun-Liang Liu Yi Miao Jian-Guo Xia Lin-Hai Zhu Dong Tang | 2006 | World Journal of Gastroenterology2006，12，1： | 23 |
| 19 | Predictive value of MTT assay as an in vitro chemosensitivity testing for gastric cancer:One institution's experience显示文摘AIM:To investigate the predictive clinical value of in vitro 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay for directing chemosensitivity in patients with gastric cancer. METHODS:Results of a total of 353 consecutive patients with gastric cancer treated with MTT-directed chemotherapy or physician’s empirical chemotherapy from July 1997 to April 2003 were reviewed and analyzed retrospectively. RESULTS:The overall 5-year survival rate of MTT- sensitive group (MSG) and control group (CG) was 47.5% and 45.1%, respectively. The results of subgroup analysis with Cox proportional-hazards model were favorable for the MSG-sensitive group. However, no statistically significant difference in survival rate was observed between the two groups. CONCLUSION:Individualized chemotherapy based on in vitro MTT assay is beneficial, but needs to be confirmed by further randomized controlled trials. | Bin Wu Jin-Shui Zhu Yi Zhang Wei-Ming Shen Qiang Zhang | 2008 | World Journal of Gastroenterology2008，14，19： | 22 |
| 20 | Abrasion characteristic analyses of solid-liquid two-phase centrifugal pump显示文摘Based on the solid-liquid two-phase mixture transportation test, the renormalization group (RNG) k-e turbulent model was utilized to simulate the solid-liquid two-phase turbulent flow in a centrifugal pump. By comparing the simulated and experimental results, inner flow features were revealed to improve the abrasion characteristic of the solid-liquid two-phase centrifugal pump. The influence of the solid phase on centrifugal pump abrasive performance is small when the particle volume fraction is less than 2.5%. The aggregation degree of the solid particles is enhanced as the particle diameter increases from 0.1 to 1 mm; however, the mixture density on the pressure side is reduced when the particle diameter increases to 1 mm for the impact of inertia. The wear on the hub is most severe for the shear stress on this position; it is also the largest. The wear characteristic is affected greatly by the parameters of the solid phase. The wear chracteristic can be optimized by decreasing the blade outlet angle. In the modified design, the blade angle is different, whereas the other geometric dimensions remain the same. The improved pump is simulated to contrast with the original pump. The results show that the values of mixture density and shear stress both decrease. The wear condition of the blade is improved to a certain extent. | LI Yi ZHU Zuchao HE Zhaohui HE Weiqiang | 2011 | Journal of Thermal Science2011，20，3： | 23 |
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