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您的检索式：作者名="Congshuo Chen"
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| 1 | CRISPR/Cas systems for the detection of nucleic acid and nonnucleic acid targets显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas)systems are becoming powerful tools for disease biomarkers detection.Due to the specific recognition,cis-cleavage and nonspecific trans-cleavage capabilities,CRISPR/Cas systems have implemented the detection of nucleic acid targets(DNA and RNA)as well as non-nucleic acid targets(e.g.,proteins,exosomes,cells,and small molecules).In this review,we first summarize the principles and characteristics of various CRISPR/Cas systems,including CRISPR/Cas9,Cas12,Cas13 and Cas14 systems.Then,various types of applications of CRISPR/Cas systems used in detecting nucleic and non-nucleic acid targets are introduced emphatically.Finally,the prospects and challenges of their applications in biosensing are discussed. | Weiran Su Junru Li Chen Ji Congshuo Chen Yuzheng Wang Huili Dai Fengqin Li Peifeng Liu | 2023 | Nano Research2023，16，7： | 3 |
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