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| 1 | The design,mechanism and biomedical application of self-healing hydrogels显示文摘Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo environment.To address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors.In this review,we focused on the current advances made in self-healing hydrogels.First,the testing methods for self-healing hydrogels were summarized.Then,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism.What's more,the biomedical application of self-healing hydrogels in vivo was discussed. | Qiwen Li Chenlu Liu Junru Wen Yongzhi Wu Yue Shan Jinfeng Liao | 2017 | Chinese Chemical Letters2017，28，9： | 11 |
| 2 | Epigallocatechin-3-gallate inhibits angiotensin Il-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9c2 rat cardiomyocytes显示文摘AngiotensinⅡ(All) has been well known to induce cardiomyocyte hypertrophy. Epigallocatechin-3-gallate (EGCG) is the main active comp on ent of green tea and it has bee n show n to exhibit strong cardioprotective potential, although the underlying molecular mechanisms remain unclear. In this study, we investigated the role and mechanism of EGCG in preventing All-induced cardiomyocyte hypertrophy using rat H9c2 cardiomyocytes cells. Reactive oxygen species assay, cell size, and mRNA expression of cardiac hypertrophy markers ANP and BNP were assessed in response to All treatment. In addition, expression of proteins involved in Hippo signaling pathway were determined by western blot analysis. We found that All treatment resulted in significant upregulation of ANP and BNP expression levels and increase in H9c2 cell size, which were markedly attenuated by EGCG treatment. Furthermore, our results suggested that EGCG inhibited Allinduced cardiac hypertrophy via regulating the Hippo signaling pathway. Therefore, EGCG may be an effective agent for preventing cardiac hypertrophy. | Yuan Ma Yongjia Hu Jiawen Wu Junru Wen Sen Li Lijuan Zhang Jie Zhang Yanfei Jue Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 4 |
| 3 | Vertical structure and seasonal variation of tidal and residual currents in the northern Huanghai Sea显示文摘Analysis of tidal current and sea level has been made based on the observations from the summer of 2006 to the winter of 2007,respectively.The result indicates that a two-layer structure of residual current exists in summer,with its upper layer going northwestward and the lower layer southeastward.In addition,some strong residuals exist in the neighboring depth of the pycnocline during the current period of astronomical tide.In winter,except some individual layersthe residual currents mostly direct to the northwest,from which we can see the fluctuation of abnormal sea-level and the appearance of associated current because of the changes of the wind field.The analysis of tidal ellipse indicates that the direction of the maximum semidiurnal component is clockwise from summer to winter,with an angle of 16-18.Moreover,in summer the semidiurnal component rotates with depth clockwise while the diurnal component counterclockwise.However,the vertical structure is almost homogeneous in winter. | SONG Jun GUO Junru QIAO Lulu MU Lin YAO Zhigang LIU Yang LI Huan BAO Xianwen SUN Xiaoyan GAO Jia | 2011 | Acta Oceanologica Sinica2011，30，5： | 4 |
| 4 | Determining the optimal time for bortezomib-based induction chemotherapy followed by autologous hematopoietic stem cell transplant in the treatment of multiple myeloma显示文摘In our study, we determined the efficacy of bortezomib-based induction therapy followed by autologous stem cell transplant (ASCT) in newly diagnosed and relapsed/refractory (R/R) multiple myeloma (MM) patients and compared the advantages of early versus late transplant. We used a retrospective analysis to examine 62 patients, including 46 cases of newly diagnosed MM (early transplant group) and 16 cases of relapsed/refractory MM (late transplant group). All of these patients received bortezomib-based induction therapy followed by ASCT. The efficacy and side effects of the treatment regimen were analyzed. Patients' overall survival (OS) and progression-free survival (PFS) times were determined. The ratio of complete remission to near-complete remission (CR/nCR) was 69.5% versus 56.2% (P=0.361), respectively, for the early transplant group versus the late transplant group, respectively, after receiving bortezomib-based induction therapy; the overall response rates of the two group were 91.3% and 81.2%, respectively (P=0.369). After receiving ASCT, the CR/nCR of the two groups increased to 84.8% and 81.3%, respectively. The median time required for neutrophil engraftment of the early transplant group and the late transplant group was 11 and 14.5 days, respectively (P=0.003); the median time required for platelet engraftment was 13 and 21.5 days (P=0.031), respectively. There were no significant differences in the toxic side effects observed during induction therapy and ASCT between the two groups. The OS of the two groups was not statistically different (P=0.058). The PFS of the early transplant group and the late transplant group was 41.6 and 26.5 months, respectively (P=0.008). Multivariate analysis demonstrated that the time of receiving ASCT, the types of M protein, and the International Staging System (ISS) stage were all independent factors that influenced PFS. In conclusion, patients in a suitable condition for ASCT should be recommended to have an early ASCT immediately after diagnosis. | Junru Liu Juan Li Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Chinese Journal of Cancer Research2013，25，2： | 4 |
| 5 | CRISPR/Cas systems for the detection of nucleic acid and nonnucleic acid targets显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas)systems are becoming powerful tools for disease biomarkers detection.Due to the specific recognition,cis-cleavage and nonspecific trans-cleavage capabilities,CRISPR/Cas systems have implemented the detection of nucleic acid targets(DNA and RNA)as well as non-nucleic acid targets(e.g.,proteins,exosomes,cells,and small molecules).In this review,we first summarize the principles and characteristics of various CRISPR/Cas systems,including CRISPR/Cas9,Cas12,Cas13 and Cas14 systems.Then,various types of applications of CRISPR/Cas systems used in detecting nucleic and non-nucleic acid targets are introduced emphatically.Finally,the prospects and challenges of their applications in biosensing are discussed. | Weiran Su Junru Li Chen Ji Congshuo Chen Yuzheng Wang Huili Dai Fengqin Li Peifeng Liu | 2023 | Nano Research2023，16，7： | 3 |
| 6 | Definition of water exchange zone between the Bohai Sea and Yellow Sea and the effect of winter gale on it显示文摘The marine dynamic environment of the Bohai Sea and the Yellow Sea in the winter of 2006 is simulated by the Regional Ocean Modelling System(ROMS) marine numerical model. Using the simulated temperature and salinity, the water exchange zone between the Bohai Sea and Yellow Sea is defined through the Spectral Mixture Model(SMM). The influence of winter gales on the water exchange is also discussed. It is found that the Yellow Sea water masses in winter are distributed in a 'tongue' shape in the Bohai Strait region, the water exchange zone presents a zonal distribution along the margin of the 'tongue', with a tendency of running from northwest to southeast, and the water exchange is intensified at the tip of the 'tongue'. Besides, the coastal area in the northernmost Yellow Sea does not participate in the water exchange between the Bohai Sea and Yellow Sea. The result shows that the winter gale events play a role in enhancing the water exchange. It is specifically shown by the facts: the Yellow Sea warm current is enhanced to intrude the Bohai Sea by the gale process; the water exchange zone extends into the Bohai Sea; the water exchange belt in the southern part becomes wider; the mixture zone of river runoff with the Bohai Sea water upon its entry is enlarged and shifts northwards. Within two days after the gale process, the exchange zone retreats toward the Yellow Sea and the exchange zone resulted from the Huanghe River(Yellow River) runoff also shrinks back shoreward. | SONG Jun GUO Junru LI Jing MU Lin LIU Yulong WANG Guosong LI Yan LI Huan | 2017 | Acta Oceanologica Sinica2017，36，1： | 2 |
| 7 | Characterization of a Novel Weak Allele of RGA1/D1 and Its Potential Application in Rice Breeding显示文摘Semi-dwarfing improves the lodging resistance and yield of rice,and the vast majority of modern rice varieties harbor the sd1 allele to decrease plant height,resulting in reduced genetic diversity and negative agronomic traits.Thus,exploring alternative sources of dwarfism is imperative for rice breeding.Here,we identified a novel RGA1 allele,d1-w,from a local indica variety Xiaolixiang(XLX)using a map-based cloning approach.Compared with other rice varieties,RGA1 in XLX contained a unique single nucleotide polymorphism that resulted in an additional transcript and reduced functional RGA1 transcript level.The RGA1 from Nipponbare was introduced into XLX to estimate the value of d1-w in rice breeding.Compared with transgenic XLX plants(XLX^(D1)),XLX exhibited reduced plant height,increased stem strength,lower reactive oxygen species accumulation,delayed senescence,stronger photosynthesis,higher grain yield and quality(including external,milling and nutritional qualities),and enhanced resistance to drought and Rhizoctonia solani.Therefore,we proposed that the d1-w allele has potential as an excellent dwarfism resource for rice breeding. | LIU Yantong LI Ting JIANG Zhishu ZENG Chuihai HE Rong QIU Jiao LIN Xiaoli PENG Limei SONG Yongping ZHOU Dahu CAI Yicong ZHU Changlan FU Junru HE Haohua XU Jie | 2022 | Rice science2022，29，6： | 2 |
| 8 | High prevalence of hepatitis B virus infection in multiple myeloma显示文摘 | Beihui Huang Juan Li Zhenhai Zhou Dong Zheng Junru Liu Mei Chen | 2012 | Leukemia & Lymphoma2012，，： | 2 |
| 9 | Comparison of dominant frequency attenuation of blasting vibration for different charge structures显示文摘Dominant frequency attenuation is a significant concern for frequency-based criteria of blasting vibration control.It is necessary to develop a concise and practical prediction equation describing dominant frequency attenuation.In this paper,a prediction equation of dominant frequency that accounts for primary parameters influencing the dominant frequency was proposed based on theoretical and dimensional analyses.Three blasting experiments were carried out in the Chiwan parking lot for collecting blasting vibration data used to conduct regression analysis of the proposed prediction equation.The fitting equations were further adopted to compare the reliability of three different types of dominant frequencies in the proposed equation and to explore the effects of different charge structures on the dominant frequency attenuation.The apparent frequency proved to be more reliable to express the attenuation law of the dominant frequency.The reliability and superiority of the proposed equation employing the apparent frequency were verified by comparison with the other five prediction equations.The smaller blasthole diameter or decoupling ratio leads to the higher initial value and corresponding faster attenuation of the dominant frequency.The blasthole diameter has a greater influence on the dominant frequency attenuation than the decoupling ratio does.Among the charge structures applied in the experiments,the charge structure with decoupling ratio of 1.5 and blasthole diameter of 48 mm results in the greatest initial value and corresponding fastest attenuation of the dominant frequency. | Pengchang Sun Wenbo Lu Junru Zhou Xincheng Huang Ming Chen Qi Li | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 2 |
| 10 | Functionalized Fiber-Based Strain Sensors:Pathway to Next-Generation Wearable Electronics显示文摘Wearable strain sensors are arousing increasing research interests in recent years on account of their potentials in motion detection,personal and public healthcare,future entertainment,man-machine interaction,artificial intelligence,and so forth.Much research has focused on fiber-based sensors due to the appealing performance of fibers,including processing flexibility,wearing comfortability,outstanding lifetime and serviceability,low-cost and large-scale capacity.Herein,we review the latest advances in functionalization and device fabrication of fiber materials toward applications in fiber-based wearable strain sensors.We describe the approaches for preparing conductive fibers such as spinning,surface modification,and structural transformation.We also introduce the fabrication and sensing mechanisms of state-of-the-art sensors and analyze their merits and demerits.The applications toward motion detection,healthcare,man-machine interaction,future entertainment,and multifunctional sensing are summarized with typical examples.We finally critically analyze tough challenges and future remarks of fiber-based strain sensors,aiming to implement them in real applications. | Zekun Liu Tianxue Zhu Junru Wang Zijian Zheng Yi Li Jiashen Li Yuekun Lai | 2022 | Nano-Micro Letters2022，14，4： | 2 |
| 11 | Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro显示文摘Background and Aims:Collagenβ(1-O)galactosyltransferase 25 domain 1(GLT25D1)is associated with collagen production and glycosylation,and its knockout in mice results in embryonic death.However,its role in liver fibrosis remains elusive,particularly in hepatic stellate cells(HSCs),the primary collagen-producing cells associated with liver fibrogenesis.Herein,we aimed to elucidate the role of GLT25D1 in HSCs.Methods:Bile duct ligation(BDL)-induced mouse liver fibrosis models,primary mouse HSCs(mHSCs),and transforming growth factor beta 1(TGF-β1)-stimulated LX-2 human hepatic stellate cells were used in in vivo and in vitro studies.Stable LX-2 cell lines with either GLT25D1 overexpression or knockdown were established using lentiviral transfection.RNA-seq was performed to investigate the genomic differences.HPLCMS/MS were used to identify glycosylation sites.Scanning electronic microscopy(SEM)and second-harmonic generation/two-photon excited fluorescence(SHG/TPEF)were used to image collagen fibril morphology.Results:GLT25D1 expression was upregulated in nonparenchymal cells in human cirrhotic liver tissues.Meanwhile,its knockdown attenuated collagen deposition in BDL-induced mouse liver fibrosis and inhibited mHSC activation.GLT25D1 was overexpressed in activated versus quiescence LX-2 cells and regulated in vitro LX-2 cell activation,including proliferation,contraction,and migration.GLT25D1 also significantly increased liver fibrogenic gene and protein expression.GLT25D1 upregulation promoted HSC activation and enhanced collagen expression through the TGF-β1/SMAD signaling pathway.Mass spectrometry showed that GLT25D1 regulated the glycosylation of collagen in HSCs,affecting the diameter of collagen fibers.Conclusions:Collectively,the upregulation of GLT25D1 in HSCs promoted the progression of liver fibrosis by affecting HSCs activation and collagen stability. | Shiwei Wang Lingling He Fan Xiao Meixin Gao Herui Wei Junru Yang Yang Shu Fuyang Zhang Xiaohui Ye Ping Li Xiaohua Hao Xingang Zhou Hongshan Wei | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 12 | Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins显示文摘Bendamustine 是有在治疗的一些功效的一个 bifunctional alkylating 代理人最新诊断了并且 relapsed/refractorymultiple 骨髓瘤(公里) 。Everolimus, rapamycin (mTOR ) 的一个哺乳动物的目标禁止者,是在许多癌症有功效的另外的答应 chemotherapeuticagent。我们调查了个人和 combinational 在公里房间线(RPMI8226 和 MM1.S ) 和主要公里房间的 thesedrugs 的细胞毒素的效果。我们的结果表明了这些药的 synergistic 效果,它为 p53-wild-type 和 p-53-deleted 公里房间是有效的,但是在从 healthydonor 的 mononuclear 房间是最小的。有二个代理人的联合治疗禁止了增长并且作为 assessedby Annexin-V/PI 染色, caspase-3 降级,和 PARP 劈开支持了 cytotoxicity 和 apoptosis。房间死亡与 thepro-apoptotic 蛋白质 Bax 的起来规定和 anti-apoptotic 蛋白质 Mcl-1 和 survivin 的下面规定被联系。联合 drugtreatment 也在 mTOR 的下游的目标蛋白质的层次支持了减少小径, p70s6k,和 4EBP-1,以及在 MM1.S 房间的肿瘤 suppressor 蛋白质 p53 的 phosphorylation 的水平的增加。p21 也是有二药的 down-regulatedupon 治疗,建议通过房间周期拘捕的版本的促进感受性的机制。我们的 resultsdemonstrate 可以贡献 everolimus 和 bendamustine 的 synergistic cytotoxicity,并且为公里的组合处理为申请向一个基本原理提供 alkylating 代理人和 mTOR 禁止者 infuture 的规章的因素的一个网络临床的实践。 | Bo Lu Juan Li Jingxuan Pan Beihui Huang Junru Liu Dong Zheng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 1 |
| 13 | Identification and fine-mapping of quantitative trait loci(QTL) conferring rice false smut resistance in rice显示文摘Rice false smut(RFS) is a rice fungal disease caused by the biotrophic fungus Ustilaginoidea virens(Cooke) Takahashi. The pathogenic fungus specifically infects rice spikelets at the booting stage and coverts the infected spikelets into false smut balls consisting of hyphae and chlamydospores(Ashizawa et al., 2012);Sun et al. | Yifeng Huang Kaixuan Cui Zhen Zhang Rongyao Chai Hongguang Xie Jianyao Shou Junru Fu Guolin Li Jiyun Liu Shuangqing Wu Guochang Sun Jianfu Zhang Yiwen Deng Zuhua He | 2023 | Journal of Genetics and Genomics2023，50，4： | 1 |
| 14 | Hepatitis B virus reactivation in patients with multiple myeloma receiving bortezomib-containing regimens followed by autologous stem cell transplant显示文摘 | Juan Li Beihui Huang Ying Li Dong Zheng Zhenhai Zhou Junru Liu | 2015 | Leukemia & Lymphoma2015，，6： | 1 |
| 15 | Electrostatic Interaction Tailored Anion-Rich Solvation Sheath Stabilizing High-Voltage Lithium Metal Batteries显示文摘Through tailoring interfacial chemistry,electrolyte engineering is a facile yet effective strategy for highperformance lithium(Li)metal batteries,where the solvation structure is critical for interfacial chemistry.Herein,the effect of electrostatic interaction on regulating an anion-rich solvation is firstly proposed.The moderate electrostatic interaction between anion and solvent promotes anion to enter the solvation sheath,inducing stable solid electrolyte interphase with fast Li+transport kinetics on the anode.This asdesigned electrolyte exhibits excellent compatibility with Li metal anode(a Li deposition/stripping Coulombic efficiency of 99.3%)and high-voltage LiCoO_(2) cathode.Consequently,the 50μm-thin Li||high-loading LiCoO_(2) cells achieve significantly improved cycling performance under stringent conditions of high voltage over 4.5 V,lean electrolyte,and wide temperature range(-20 to 60℃).This work inspires a groundbreaking strategy to manipulate the solvation structure through regulating the interactions of solvent and anion for highperformance Li metal batteries. | Junru Wu Ziyao Gao Yao Wang Xu Yang Qi Liu Dong Zhou Xianshu Wang Feiyu Kang Baohua Li | 2022 | Nano-Micro Letters2022，14，9： | 1 |
| 16 | Hepatitis B virus infection status is an independent risk factor for multiple myeloma patients after autologous hematopoietic stem cell transplantation显示文摘 | Juan Li Junru Liu Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Tumor Biology2013，，3： | 1 |
| 17 | 125I Radioactive Particles Drive Protective Autophagy in Hepatocellular Carcinoma by Upregulating ATG9B显示文摘Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its wide clinical application.Methods:We investigated the cellular responses to 125I radioactive particles treatment and autophagy-related 9B(ATG9B)silencing in HCC cell lines and Hep3B xenografted tumor model using Cell Counting Kit-8 reagent,western blotting,immunofluorescence,flow cytometry,transmission electron microscopy and immunohistochemistry.Results:In this study,we demonstrated that 125I radioactive particles induced cell apoptosis and protective autophagy of HCC in vitro and in vivo.Inhibition of autophagy enhanced the radiosensitivity of HCC to 125I radioactive particles.Moreover,125I radioactive particles induced autophagy by upregulating ATG9B,with increased expression level of LC3B and decreased expression level of p62.Furthermore,ATG9B silencing downregulated LC3B expression and upregulated p62 expression and enhanced radiosensitivity of HCC to 125I radioactive particles in vitro and in vivo.Conclusions:Inhibition of ATG9B enhanced the antitumor effects of 125I particle radiation against HCC in vitro and in vivo.Our findings suggest that 125I particle radiation plus chloroquine or/and the ATG9B inhibitor may be a novel therapeutic strategy for HCC. | Yunhua Xiao Jing Yuan Chongshuang Yang Junru Xiong Liangyu Deng Qinghua Liang Chuang He Liangshan Li Fengtian He Xuequan Huang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 1 |
| 18 | Soluble Fms-like Tyrosine Kinase-1 Expression Inhibits the Growth of Multiple Myeloma in Nude Mice显示文摘Angiogenesis 包括多重骨髓瘤(公里) 是在生长和前进 ofhematological 恶意的一个必要因素。脉管的 endothelial 生长因素和它的受体被显示了是为治疗肿瘤的目标。这研究探索效果在裸体老鼠的公里房间线 KM3 的生长上的可溶的脉管的 endothelial 生长因素受体 Fms-liketyrosine kinase-1 (sFLT-1 ) 的调停 ofadenovirus 的交货。sFLT-1 cDNA 被反向的抄写聚合酶链反应从人的脐的静脉 endothelial 房间放大并且被用作 transgene 构造带 sFLT-1 (ADV-sFLT ) 的 adenoviral 向量。Cellproliferation 和 3-[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金被执行在人的脐的静脉 endothelial 房间和 KM3 房间 invitro 上评估 ADV-sFLT 的效果。十八只女 BALB/c 裸体老鼠与 KM3 房间皮下地被接种,并且他们随机被划分成三个组并且与 ADV-sFLT 静脉内地注射了, ADV-LacZ,缓冲 orphosphate 盐(PBS ) 。KM3 异种皮移植的体积一个星期被测量两次。在起始的处理,在与 ADV-sFLT 对待的鼠标的公里异种皮移植的卷, ADV-LacZ,或 PBS 以后的三个星期是 770.32 ± 2 8.73 mm^3, 1983.36 ± 4 3.72 mm^3,和 2042.05 ± 8 2.31 mm^3,分别地(P<0.01, ADV-sFLT 对 ADV-LacZ 或 PBS ) 。微容器密度的价值在与 ADV-sFLT, ADV-LacZ,和 PBS 治疗的肿瘤是 29.17 ± 6 .85,79.17 ± 7 .35,和 78.83 ± 8 .54,分别地(P<0.01, ADV-sFLT 对 ADV-LacZ 或 PBS ) 。这研究建议调停侵入人体气管粘膜的病菌的 sFLT-1gene 极大地禁止在老鼠异种皮移植的生长和 angiogenesis,和力量为公里作为新治疗服务的导出公里的肿瘤。 | Junru LIU Juan LI Chang SU Beihui HUANG Shaokai LUO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 1 |
| 19 | Characterization of soy β-conglycinin-dextran conjugate prepared by Maillard reaction in crowed liquid system显示文摘 | ZHANG Xi QI Junru LI Kangkang | 2012 | Food Research International2012，49，： | 1 |
| 20 | Computational and experimental studies of mercury adsorption on unburned carbon present in fly ash显示文摘 | Junru Li M. Mercedes Maroto-Valer | 2012 | Carbon2012，，5： | 1 |
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