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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 3 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 4 | Colorectal cancer in the young显示文摘 | Jessica B O’Connell Melinda A Maggard Edward H Livingston Cifford K Yo | 2004 | The American Journal of Surgery2004，，： | 2 |
| 5 | Environmental water allocation:principles,policies and praetiees显示文摘 | SCHOFIELD N BURT A AND CONNELL D | 2003 | Land and Water of Australia2003，，： | 1 |
| 6 | Immune privilege or inflammation? Insights into the Fas ligand enigma显示文摘 | O'Connell J Houston A Bennett MW | 2001 | Nat Med2001，7，3： | 1 |
| 7 | Updated population-based review of carcinoid tumors 显示文摘 | Maggard M A O'Connell J B Ko C Y | 2004 | Ann Surg2004，240，1： | 1 |
| 8 | Detection of hippocampal pathology inintractable partial epilepsy:increased sensitivity with quantitative magnetic resonance T2 relaxometry显示文摘 | Jackson GD Connel y A Duncan JS | | 0，，： | 1 |
| 9 | Complications asmciated with the bacille Calmette-Guérin vaccination in Ireland显示文摘 | Bolger T O'Connell M Menon A | | 0，，07： | 1 |
| 10 | Industry clusters: An an- tidote for knowledge sharing and collaborative innova- tion? 显示文摘 | Connell J Kriz A Thorpe M | 2014 | Journal of Knowledge Management2014，18，1： | 1 |
| 11 | Does training generally work?The remms to in-company training显示文摘 | Barrett A O'Connell P J | 2001 | Industrial and Labor Relations Review2001，54，3： | 1 |
| 12 | Exercise beliefs and behaviors among older employees: A health promotion trial 显示文摘 | Sharpe P A Connel C M | 1992 | The Gerontologist1992，32，4： | 1 |
| 13 | Nurses'atti- tudes to single checking medications:before and after its use显示文摘 | O'Connell B Crawford S Tull A | 2007 | Int J Nurs Pratt2007，13，6： | 1 |
| 14 | Treatment of lateral epicondylitis using skin-derived tenocyte-like cells显示文摘 | Connell D Datir A Alyas F | 2009 | Br J Sports Med2009，43，4： | 1 |
| 15 | Treatment of open apex teeth using two types of white mineral trioxide aggregate after initial dressing with calcium hydroxide in children显示文摘 | Moore A Howley MF O′Connell AC | | 0，，03： | 1 |
| 16 | Residue management effects on soil carbon and nutrient contents and growth of second rotation eucalypts 显示文摘 | Mendham D S O'connell A M Grove T S | 2003 | Forest Ecology and Management2003，181，3： | 1 |
| 17 | Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1and CD11a显示文摘 | Roberts A I O’Connell S M and Ebert E C | 1993 | Cancer Res1993，53，7： | 1 |
| 18 | Tech- nique for Monolithic Fabrication of Microlens Arrays 显示文摘 | POPVIC Z D SPRAGUE R A CONNEL G A N | 1988 | Applied Optics1988，27，7： | 1 |
| 19 | Gene expression analysis of strawberry achene and receptacle maturation using DNA microarrays显示文摘 | AHARONI A O'CONNELL A P | 2002 | Exp Bot2002，53，377： | 1 |
| 20 | Change in soil carbon after land cleating or afforestation in highly weathered lateritic and sandy soils of south-western Australia显示文摘 | Mendham D S O'connell A M Grove T S | 2003 | Agriculture Ecosytems and Environment2003，95，： | 1 |
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