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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Cross-Country Evidence on the Value of Corporate Indus-trial and International Diversification显示文摘 | HOUSTON J NARANJO A | 2004 | Journal of Corporate Finance2004，10，5： | 1 |
| 3 | Immune privilege or inflammation? Insights into the Fas ligand enigma显示文摘 | O'Connell J Houston A Bennett MW | 2001 | Nat Med2001，7，3： | 1 |
| 4 | Evolutionarily stable levels of vigilance as a function of group size 显示文摘 | MCNAMARA J M HOUSTON A I | 1992 | Animal Behaviour1992，43，： | 1 |
| 5 | Induction of monocyte tissue factor ex pression by homocysteine:A possible mechanism for thrombosis 显示文摘 | Khufia A Houston DS | 2000 | Blood2000，96，： | 1 |
| 6 | Surface leakage currents in SiN passivated AIGaN/GaN HFETs 显示文摘 | TAN W S UREN M J HOUSTON P A | 2006 | IEEE Electron Device Letters2006，27，1： | 1 |
| 7 | Induction of monocyte tissue factor expression by homocysteine: a possible mechanism for thrombosis 显示文摘 | Khajuria A Houston DS | 2000 | Blood2000，96，3： | 1 |
| 8 | Transmission of BSE by blood transfusion in sheep显示文摘 | Houston F Foster JD Chong A | 2000 | Lancet2000，356，： | 1 |
| 9 | A comparison of nutrient sources and behaviour in two lowland subcatchments of the River Wye显示文摘 | Houston J A Brooker M P | | 0，，： | 1 |
| 10 | Impaired brachial artery endothelial function is not predicted by elevated triglycerides显示文摘 | Schnell GB Robertson A Houston D | 1999 | J Am Coil Cardiol1999，33，7： | 1 |
| 11 | Differential antide- pressant symptom efficacy:placebo - controlled comparisons of du- loxetine and SSRIs ( fluoxetine, paroxetine, escitalopram) 显示文摘 | Mallinckrodt CH Parkash A Houston JP | 2007 | Neu- ropsychobioiogy2007，56，23： | 1 |
| 12 | Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo显示文摘 | Houston A Walsron-Lynch F D Bennett M N et aI | 2003 | Int J Cancer2003，1，10： | 1 |
| 13 | Cancellation and focus:The Role of Shared and Unique Features in the Choice Process显示文摘 | HOUSTON D A SHERMAN S T | 1995 | Journal of Experimental Social Psychology1995，31，4： | 1 |
| 14 | Feature Matching,Unique Features,and the Dynamics of the Choice Process:Predecision Conflict and Postdecision Satisfaction显示文摘 | HOUSTON D A SHERMAN S T BAKER S M | 1991 | Journal of Experimental Social Psychology1991，27，5： | 1 |
| 15 | A polymor phism in the 5'-Untranslated region of the porcine cholecys- tokinin type A receptor gene affects feed in take and growth 显示文摘 | Houston R D Haley C S Archibald A L | 2006 | Genetics Sociaety of America2006，10，： | 1 |
| 16 | Induction of monocyte tissue factor expression by homocysteine:a possible mechanism for thrombosis显示文摘 | Khajuria A Houston DS | 2000 | Blood2000，96，3： | 1 |
| 17 | Prion diseases: BSE in sheep bred for resistance to infeetion显示文摘 | Houston F Goldmann W Chong A | 2003 | Nature2003，423，6939： | 1 |
| 18 | Bone density and alendronate effects in Duchenne Muscular Dystrophy patients显示文摘 | Houston C Mathews K Shibli-Rahhal A | 2014 | Muscle Nerve2014，49，4： | 1 |
| 19 | Knowl- edge, attitudes, and consequences of menstrual health in urban adolescent females 显示文摘 | Houston AM Abraham A Huang Z | 2006 | J Pediatr Adolesc Gynecol2006，19，4： | 1 |
| 20 | Cloning,expression,and sequence analysis of a cytolytic enterotoxin gene from Aeromonas hydrophila显示文摘 | Chopra A K Houston C W Peterson J W | 1993 | Can J Microbiol1993，39，： | 1 |
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