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| 1 | Electrical synapses in the mammalian brain 显示文摘 | CONNORS B LONG M A | 2004 | Annu Rev Neurosci2004，27，： | 1 |
| 2 | Temperature and frequency dependent electrical characterization of HfO2/InxGa1-xAs interfaces using capacitance-voltage and conductance methods显示文摘 | O’CONNOR E MONAGHAN S LONG R D | 2009 | Appl Phys Lett2009，94，10： | 1 |
| 3 | Disseminated tuberculosis with and without a miliary pattern on chest radiograph:a clinical-pathologic-radiologic correlation显示文摘 | Long R O'Connor R Palayew M | 1997 | Int J Tuberc Lung Dis1997，1，1： | 1 |
| 4 | Electrical synapses in the mam- malian brain显示文摘 | Connors BW Long MA | 2004 | Ann Rev Neurosci2004，27，： | 1 |
| 5 | Stem cell-based in utero therapies for spina bifida: implications for neural regeneration显示文摘The history: Myelomeningocele - also known as spina bifida- is a devastating congenital anomaly of the central nervoussystem that is caused by the malformation of the spinal cordand vertebral column during embryogenesis. Depending onthe location of the spina bifida lesion on the spine, patientssuffer from neurological dysfunction ranging from paresisand incontinence to complete paralysis. The current standardof care for spina bifida is in utero surgical repair of the defect,which has been shown to minimize the secondary deficits associatedwith this disorder (Adzick et al., 2011). Despite thesesuccesses, this approach does not reliably improve neurologicfunction of affected children. Several groups, including ourown, have performed studies aimed at augmenting the inutero surgical repair of spina bifida by applying principlesof stem cell and tissue engineering to provide an enhancedprotection of the exposed neural elements (Saadai et al., 2011,2013; Wang et al., 2015; Brown et al., 2016). The ultimategoal of these studies is to improve the neurologic function inpatients while maintaining the benefits of the existing fetalsurgical treatment. | Connor Long Lee Lankford Aijun Wang | 2019 | Neural Regeneration Research2019，14，2： | 1 |
| 6 | Electrical synapses in the mammalian brain显示文摘 | Connors BW Long MA | 2004 | Annu Rev Neurosci2004，27，： | 1 |
| 7 | Subacute Lack of Asthma Control and Acute Asthma Exacerbation History as Predictors of Subsequent Acute Asthma Exacerbations :Evidence From Managed Care Data显示文摘 | O'Connor RD Bleecker ER Long AD | 2010 | Journal of Asthma2010，47，4： | 1 |
| 8 | :A novel latentmembrane 2 transcript expressed in Epstein-Barr viruspositive NK-and T-cell lymphoproliferative disease encodes a target for cellularimmunotherapy显示文摘 | Fox CP Haigh TA Taylor GS Long HM Lee SP Shannon-Lowe C O’Connor S Bollard CM Iqbal J Chan WC | 2010 | Blood2010，，116： | 1 |
| 9 | Single-entity electrochemistry at confined sensing interfaces显示文摘Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes.Recent advances in the chemical measurement provide a means for ultra-sensitive analysis.Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity.In this review,we summarize the recent progress in single-entity electrochemistry of single molecules,single particles,single cells and even brain analysis.The benefits of confining these entities to a compatible size sensing interface are exemplified.Finally,the opportunities and challenges of single entity electrochemistry are addressed. | Yi-Lun Ying Jiajun Wang Anna Rose Leach Ying Jiang Rui Gao Cong Xu Martin A.Edwards Andrew D.Pendergast Hang Ren Connor K.Terry Weatherly Wei Wang Paolo Actis Lanqun Mao Henry S.White Yi-Tao Long | 2020 | Science China Chemistry2020，63，5： | 0 |
| 10 | Early gestation chorionic villi-derived stromal cells for fetal tissue engineering显示文摘AIM: To investigate the potential for early gestation placenta-derived mesenchymal stromal cells(PMSCs) for fetal tissue engineering.METHODS: PMSCs were isolated from early gestation chorionic villus tissue by explant culture. Chorionic villus sampling(CVS)-size tissue samples(mean = 35.93 mg)were used to test the feasibility of obtaining large cell numbers from CVS within a clinically relevant timeframe. We characterized PMSCs isolated from 6 donor placentas by flow cytometry immunophenotyping, multipotency assays, and through immunofluorescent staining. Protein secretion from PMSCs was examined using two cytokine array assays capable of probing for over 70 factors in total. Delivery vehicle compatibility of PMSCs was determined using three common scaffold systems: fibrin glue, collagen hydrogel, and biodegradable nanofibrous scaffolds made from a combination of polylactic acid(PLA) and poly(lactic-co-glycolic acid)(PLGA). Viral transduction of PMSCs was performed using a Luciferase-GFPcontaining lentiviral vector and efficiency of transduction was tested by fluorescent microscopy and flow cytometry analysis.RESULTS: We determined that an average of 2.09 × 106(SD ± 8.59 × 105) PMSCs could be obtained from CVS-size tissue samples within 30 d(mean = 27 d, SD ± 2.28), indicating that therapeutic numbers of cells can be rapidly expanded from very limited masses of tissue. Immunophenotyping by flow cytometry demonstrated that PMSCs were positive for MSC markers CD105, CD90, CD73, CD44, and CD29, and were negative for hematopoietic and endothelial markers CD45, CD34, and CD31. PMSCs displayed trilineage differentiation capability, and were found to express developmental transcription factors Sox10 and Sox17 as well as neuralrelated structural proteins NFM, Nestin, and S100 β. Cytokine arrays revealed a robust and extensive profile of PMSC-secreted cytokines and growth factors, and detected 34 factors with spot density values exceeding 103. Detected factors had widely diverse functions that include modulation of angiogenesis and immune response, cell chemotaxis, cell proliferation, blood vessel maturation and homeostasis, modulation of insulin-like growth factor activity, neuroprotection, extracellular matrix degradation and even blood coagulation. Importantly, PMSCs were also determined to be compatible with bothbiological and synthetic material-based delivery vehicles such as collagen and fibrin hydrogels, and biodegradable nanofiber scaffolds made from a combination of PLA and PLGA. Finally, we demonstrated that PMSCs can be efficiently transduced(> 95%) with a Luciferase-GFPcontaining lentiviral vector for future in vivo cell tracking after transplantation.CONCLUSION: Our findings indicate that PMSCs represent a unique source of cells that can be effectively utilized for in utero cell therapy and tissue engineering. | Lee Lankford Taryn Selby James Becker Volodymyr Ryzhuk Connor Long Diana Farmer Aijun Wang | 2015 | World Journal of Stem Cells2015，7，1： | 0 |
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