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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | DOCK8 regulates signal transduction events to control immunity显示文摘在编码 DOCK8 的基因的基因变化引起亢奋的免疫球蛋白 E 症候群(AR 催促) 的一种正染色体的后退的形式,是指了 DOCK8 缺乏。在人的 DOCK8 缺乏导致联合免疫不全疾病(首领) 的发作,临床上与多样的微生物引起的病原体,和倾向与长期的感染联系了到恶意。DOCK8 调整多样的有免疫力的房间子类型的功能,现在正在变得清楚,特别地淋巴细胞,驾驶天生、适应的有免疫力的回答。早研究证明 DOCK8 为淋巴细胞幸存,移植和有免疫力的触处形成被要求,它当 DOCK8 不在时翻译到差的病原体控制。然而,更最近的进展在调整控制 transcriptional 活动, cytokine 生产和有免疫力的房间的功能的极化的信号 transduction 事件为 DOCK8 指向了一个关键角色。这里,我们在我们 DOCK8 功能的理解总结最近的进展,对象把有免疫力的回答提升到多样的外部刺激的发信号的中介的一个新兴的角色给予特别注意。 | Conor J Kearney Katrina L Randall Jane Oliaro | 2017 | Cellular & Molecular Immunology2017，14，5： | 5 |
| 3 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 4 | Relationships between the gross,non-volaile and volatile compositions and the sensory attributes of eight hardtype cheeses 显示文摘 | Ben Lawlor J Conor Mdelahunty Jeremiah Sheehan | 2002 | Intenational Dairy Journal2002，12，6： | 1 |
| 5 | Precursors of coloreetal carcinoma 显示文摘 | MICHAEL J CONOR J ZAUBERA | 1992 | Cancer1992，70，： | 1 |
| 6 | Precursors of colorectal carcinoma 显示文摘 | Michael J Conor J Zauber A | 1992 | Cancer1992，70，5： | 1 |
| 7 | Novel biomarkers in early di- agnosis of acute myocardial infarction compared with cardiac troponin T显示文摘 | Conor J Mc Cann Ben M | 2008 | Eur Heart J2008，29，23： | 1 |
| 8 | Precursors of colore ctal Carcinoma显示文摘 | Conor J Zauber A Gottlieb LS Winawer SJ | 1992 | Cancer1992，70，5： | 1 |
| 9 | Tailored Logistics:the Next Advantage显示文摘 | FULLER J B CONOR J RAWLINSON R | 1993 | Harvard Business Review1993，，： | 1 |
| 10 | Autophony and patulous eustachian tube显示文摘 | O'CONOR A F SHEA J J | 1981 | Laryngoscope1981，91，： | 1 |
| 11 | Regarding 'Repeated pulse intramuscular injection of pralidoxime chloride in severe acute or- ganophosphorus pesticide poisoning'显示文摘 | Conors N J Weber B J Hoffman RS | 2013 | Am Emerg Med2013，31，12： | 1 |
| 12 | Characterisation of commercial Cheddar cheese flavor 2:traditional and electronic nose approach to quality assessment and market classification显示文摘 | Pattick J O Riordsn Conor M Delahunty | 2003 | International Dairy Journal2003，5，13： | 1 |
| 13 | Tailored logistics:The next advantage显示文摘 | Fuller JB Conor J Rawlinson R | 1993 | Harvard Business Review1993，，： | 1 |
| 14 | Characterisation of commercial Cheddar cheese flavor 2:study of Cheddar cheese discrimination by composition,volatile compounds and descriptive flavour assessment显示文摘 | trick J O Riordan Conor M Delahunty | 2003 | International Dairy Journal2003，5，13： | 1 |
| 15 | Biological Waste Treatment显示文摘 | Eckenfelder WW O Conor D J | 1961 | New York:Pergamom Press1961，，： | 1 |
| 16 | Tailored logistics: The next advantage显示文摘 | Fuller J B O'Conor J Rawlinson R | 1993 | Harvard Business Review1993，71，3： | 1 |
| 17 | Tailored logistics: The next advantage显示文摘 | Fuller J B O' Conor J Rawlinson R | 1993 | Harvard Business Review1993，，： | 1 |
| 18 | Tailored Logistics:The next advantage显示文摘 | Fuller F B O' Conor J Rawlinson R | 1993 | Harvard Business Review1993，71，3： | 1 |
| 19 | Correlation of Olary and Broken Hill Domains, Curnamona Province= Possi ble Relationship to Mount Isa and Other North Australian Pb Zn Ag-Bearing Successions 显示文摘 | Page R W Conor C H H StevensBP J | 2005 | Economic Geology2005，100，： | 1 |
| 20 | Segmental resection for carcinoma of the bladder: review of 102 patients显示文摘 | RESNICK M I O'CONOR V J Jr | 1973 | J Urol1973，109，6： | 1 |
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