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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Aerobic vs anaerobic exercise training effects on the cardiovascular system显示文摘Physical exercise is one of the most effective methods to help prevent cardiovascular(CV) disease and to promote CV health. Aerobic and anaerobic exercises are two types of exercise that differ based on the intensity, interval and types of muscle fibers incorporated. In this article, we aim to further elaborate on these two categories of physical exercise and to help decipher which provides the most effective means of promoting CV health. | Harsh Patel Hassan Alkhawam Raef Madanieh Niel Shah Constantine E Kosmas Timothy J Vittorio | 2017 | World Journal of Cardiology2017，9，2： | 2 |
| 3 | Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria显示文摘 | Constantin R Soldatos Dimitris G Dikeos Thomas J Paparrigopoulos | 2000 | Journal of Psychosomatic Research2000，，6： | 2 |
| 4 | Frictional characteristics of teflon-steel interfaces under dynamic conditions显示文摘 | Constantinou M C Caccese J Harris H G | 1987 | Earthquake Engineering and Structural Dynamics1987，15，6： | 1 |
| 5 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
| 6 | Efficient multi-keV X-ray sources from Ti-doped aerogel targets显示文摘 | Fournier K B Constantin C Poco J | 2004 | Phys Rev Lett2004，92，16： | 1 |
| 7 | Variation in Echinococcus: towards a taxonomic revision of the genus 显示文摘 | Thompson R C A Lymbery A J Constantine C C | 1995 | Adv Parasitol1995，35，： | 1 |
| 8 | Disruption of the actin cytoskeleton of mammalian cells by the capping complex action-fragment is inhibited by actin phosphorylation and regulated by Ca2+ ions显示文摘 | CONSTANTIN B MEERSCHAERT K VAN DEK ERCKHOVE J | 1998 | J Cell Sci1998，111，： | 1 |
| 9 | Well-posedness, global existence and blow-up phenomena for a periodic quasi-linear hyperbolic equation显示文摘 | Constantin A Escher J | 1998 | Comm Pure Appl Math1998，51，： | 1 |
| 10 | All-optical Gbit/s switching using nonlinear optical loop mirror显示文摘 | NELSON B P BLOW K J CONSTANTINE P D | 1991 | Electronics Letters1991，27，9： | 1 |
| 11 | A Chemical kinetic mechanism for atmospheric inorganic mercury显示文摘 | Seigneur C Wrobel J Constantinou E | 1994 | Environmental Science & Technology1994，28，9： | 1 |
| 12 | Global existence and blow-up for a shallow water equation显示文摘 | Constantin A Escher J | 1998 | Ann Scuola Norm SUP Pisacl Sci1998，26，4： | 1 |
| 13 | Effects of activated charcoal on callus growth and shoot organo genesis in tobacco显示文摘 | CONSTANTIN M J HENKE R R MANSUR M A | 1977 | In Vitro1977，13，5： | 1 |
| 14 | Global existence and blow-up for a shallow water equation 显示文摘 | CONSTANTIN A ESCHER J | 1998 | Ann Sc Norm Super Pisa C1 Sei1998，26，4： | 1 |
| 15 | Glyphosate associated with other herbicides for con- trol of Commelina benghalensis and Spermaeoee lati- folia显示文摘 | Ramires A C Constantin J De Oliveira J R S | 2011 | Semina-Cieneias Agrarias2011，32，3： | 1 |
| 16 | Lowering the detection limits of HIV- 1 viral load using real-time immuno-PCR for HIV- 1 p24 antigen 显示文摘 | Barletta J M Edelman D C Constantine N T | 2004 | American Journal of Clinical Pathology2004，122，1： | 1 |
| 17 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 18 | Effects of activated charcoal on callus growth and shoot organogenesis in tobacco显示文摘 | | 1977 | In Vitro1977，13，5： | 1 |
| 19 | World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients显示文摘According to global annual estimates hunger/malnutrition is the major cause of death(36 of 62 million). Cardiovascular diseases and cancer(5.44 of 13.43 million) are the major causes of death in developed countries, while lower respiratory tract infections, human immunodeficiency virus infection/acquired immunodeficiency syndrome, diarrhoeal disease, malaria and tuberculosis(10.88 of 27.12 million) are the major causes of death in developing countries with more than 70% of deaths occurring in children. The majority of approximately 800 million people with other rare diseases, including 100000 children born with thalassaemia annually receive no treatment. There are major ethical dilemmas in dealing with global health issues such as poverty and the treatment of orphan and rare diseases. Of approximately 50000 drugs about 10% are orphan drugs, with annual sales of the latter approaching 100 billion USD. In comparison, the annual revenue in 2009 from the top 12 pharmaceutical companies in Western countrieswas 445 billion USD and the top drug, atorvastatin, reached 100 billion USD. In the same year, the total government expenditure for health in the developing countries was 410 billion USD with only 6%-7% having been received as aid from developed countries. Drugs cost the National Health Service in the United Kingdom more than 20 billion USD or 10% of the annual health budget. Uncontrollable drug prices and marketing policies affect global health budgets, clinical practice, patient safety and survival. Fines of 5.3 billion USD were imposed on two pharmaceutical companies in the United States, the regulatory authority in France was replaced and clinicians were charged with bribery in order to overcome recent illegal practises affecting patient care. High expenditure for drug development is mainly related to marketing costs. However, only 2 million USD was spent developing the drug deferiprone(L1) for thalassaemia up to the stage of multicentre clinical trials. The criteria for drug development, price levels and use needs to be readdressed to improve drug safety and minimise costs. New global health policies based on cheaper drugs can help the treatment of many categories of orphan and rare diseases and millions of orphan patients in developing and developed countries. | Christina N Kontoghiorghe Nicholas Andreou Katerina Constantinou George J Kontoghiorghes | 2014 | World Journal of Methodology2014，4，3： | 1 |
| 20 | Methyl anthranilate aerosol for dispersing birds from the flight lines at Homestead Air Reserve Station显示文摘 | ENGEMAN R M PETERLA J CONSTANTIN B | 2002 | International Biodeterioration & Biodegradation2002，49，17： | 1 |
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