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| 1 | Autophagy and neurodegenerative disorders显示文摘Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders. | Evangelia Kesidou Roza Lagoudaki Olga Touloumi Kyriaki-Nefeli Poulatsidou Constantina Simeonidou | 2013 | Neural Regeneration Research2013，8，24： | 15 |
| 2 | Molecular aspects of carcinogenesis in pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer(PCa)is one of the most aggressive human solid tumors,with rapid growth and metastatic spread as well as resistance to chemotherapeutic drugs,leading rapidly to virtually incurable disease.Over the last 20 years,however,significant advances have been made in our understanding of the molecular biology of PCa,with a focus on the cytogenetic abnormalities in PCa cell growth and differentiation. DATA SOURCES:A MEDLINE search and manual cross- referencing were utilized to identify published data for PCa molecular biology studies between 1986 and 2008, with emphasis on genetic alterations and developmental oncology. RESULTS:Activation of oncogenes,deregulation of tumor suppressor and genome maintenance genes,upregulation of growth factors/growth factor receptor signaling cascade systems,and alterations in cytokine expression,have been reported to play important roles in the process of pancreatic carcinogenesis.Alterations in the K-ras proto- oncogene and the p16INK4a,p53,FHIT,and DPC4 tumor suppressor genes occur in a high percentage of tumors. Furthermore,a variety of growth factors are expressed at increased levels.In addition,PCa often exhibits alterations in growth inhibitory pathways and evades apoptosis through p53 mutations and aberrant expression of apoptosis-regulating genes,such as members of the Bcl family.Additional pathways in the development of an aggressive phenotype,local infiltration and metastasis are still under ongoing genetic research.The present paper reviews recent studies on the pathogenesis of PCa,and includes a brief reference to alterations reported for other types of pancreatic tumor. CONCLUSIONS:Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa.However,further studies are needed to better understand the fundamental changes that occur in PCa,thus leading to better diagnostic and therapeutic management. | Alexandros Koliopanos Constantinos Avgerinos Constantina Paraskeva Zisis Touloumis Dionisisa Kelgiorgi Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 4 |
| 3 | KIT exon 11 codon 557/558 deletion/insertion mutations define a subset of gastrointestinal stromal tumors with malignant potential显示文摘AIM: To study the association of the frequency and pattern of KIT and PDGFRA mutations and clinicopathological factors in a group of patients with gastrointestinal stromal tumors (GIST). METHODS: Thirty patients with GIST were examined. Exons 9, 11, 13, and 17 of the KIT and exons 12 and 18 of the PDGFRA gene were analyzed for the presence of mutations by PCR amplification and direct sequencing. RESULTS: KIT or PDGFRA mutations were detected in 21 of the 30 patients (70%). Sixteen patients had mutations within KIT exon 11, three within KIT exon 9, and two within PDGFRA exon 18. GISTs with KIT exon 9 mutations were predominantly located in the small intestine, showed a spindle cell phenotype, and were assessed as potentially malignant. GISTs with KIT exon 11 mutations were located in the stomach and intestine, showed mainly a spindle cell phenotype, and were scored as potentially malignant (P < 0.05). Tumors with KIT exon 11 codon 557/558 deletion/insertion mutations were found to be associated with a potentially malignant clinical behaviour (P < 0.003). GISTs with PDGFRA mutations located in stomach showed a mixedcell phenotype and were classified as of very low or low moderate malignant potential. CONCLUSION: Determination of KIT and PDGFRA mutations should be additional parameters for the better prediction of GISTs clinical behaviour. Tumors with deletion/insertion mutations affecting codons 557/558 of the KIT gene seem to represent a distinct subset of malignant GISTs. | Katerina Kontogianni-Katsarou Euthimios Dimitriadis Constantina Lariou Evi Kairi-Vassilatou Nikolaos Pandis Agatha Kondi-Paphiti | 2008 | World Journal of Gastroenterology2008，14，12： | 4 |
| 4 | Clinical outcomes of compensated and decompensated cirrhosis: A long term study显示文摘AIM: To study these characteristics and prognostic patterns in a Greek patient population.METHODS: We analyzed a large cohort of cirrhotic patients referred to the department of Gastroenterology and Hepatology and the outpatient clinics of this tertiary hospital, between 1991 and 2008. We included patients with established cirrhosis, either compensated or decompensated, and further decompensation episodes were registered. A data base was maintained and updated prospectively throughout the study period.We analyzed differences in cirrhosis aetiology, time to and mode of decompensation, hepatocellular carcinoma(HCC) occurrence and ultimately patient survival.RESULTS: Five hundreds and twenty-two patients with median age 67(range, 29-91) years and average follow up 9 years-10 mo(range, 1-206 mo) were studied. Commonest aetiology was hepatitis C virus(HCV, 41%) followed by alcohol(31%). The median survival time in compensated cirrhotics was 115 mo(95%CI: 95-133), whereas in decompensated patients was 55 mo(95%CI: 36-75). HCV patients survived longer while HBV patients had over twice the risk of death of HCV patients. The median time to decompensation was 65 mo(95%CI: 51-79), with alcoholics having the highest risk(RR = 2.1 vs HCV patients). Hepatitis B virus(HBV) patients had the highest risk of HCC, alcoholics the lowest. Leading causes of death: liver failure, hepatorenal syndrome, sepsis and HCC progression. CONCLUSION: Cirrhosis aetiology and decompensation at presentation were predictors of survival. Alcoholics had the highest decompensation risk, HBV cirrhotics the highest risk of HCC and HCV cirrhotics the highest decompensation-free time. | Dimitrios N Samonakis Mairi Koulentaki Constantina Coucoutsi Aikaterini Augoustaki Chryssavgi Baritaki Emmanuel Digenakis Nikolaos Papiamonis Maria Fragaki Erminia Matrella Elias A Kouroumalis Maria Tzardi | 2014 | World Journal of Hepatology2014，6，7： | 4 |
| 5 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence detection 显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | Journal of Chromatography A2003，1002，： | 1 |
| 6 | Serum transforming growth factor-β1 is related to the degree of immunoparesis in patients with multiple myeloma显示文摘 | Maria-Christina Kyrtsonis Constantina Repa George (XXXV) Z Dedoussis Athanasia Mouzaki Argyris Simeonidis Marina Stamatelou Alice Maniatis | 1998 | Medical Oncology1998，，2： | 1 |
| 7 | Export Performance, Competitiveness and Commodity Composition显示文摘 | PANAYIOTIS P ATHANASOGLOU CONSTANTINA BACKINEZOS EVAGELIA A GEORGIOU | 2010 | Bank of Greece Working Paper2010，，5： | 1 |
| 8 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence de- tection显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | J Chromatogr A2003，100，2： | 1 |
| 9 | Transient ST- segment depression during paroxysms of atrial fibrillation in otherwise normal individuals: relation with underlying coronary artery disease显示文摘 | Aristides A Konstantinos A Constantina A | 2007 | Journal of the American college of cardiology2007，19，50： | 1 |
| 10 | Effect of the addition of different dietary fiber and edible cereal bran Ssources on the baking and sensory characteristics of cupcakes 显示文摘 | Dimitra M Lebesi Constantina Tzia | 2009 | Food Bioprocess Technol2009，1，： | 1 |
| 11 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post - column indirect fluorescence detection 显示文摘 | Constantine D Constantina N Christos G | 2003 | J Chromatogr A2003，1002，12： | 1 |
| 12 | Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma显示文摘 | Michael G. Alexandrakis Constantina A. Pappa Spiros Miyakis Aikaterini Sfiridaki Maria Kafousi Athanassios Alegakis Efstathios N. Stathopoulos | 2006 | European Journal of Internal Medicine2006，，6： | 1 |
| 13 | On thecomplete aerobic microbial mineralization of linear alkylbenzenesulfonate显示文摘 | CONSTANTINA P KATERINA S MICHAEL K | 2007 | Desalination2007，215，123： | 1 |
| 14 | Direct synthesis of 2,4-diaminoquinazolines from 2-iluoro- benzonitriies 显示文摘 | John B Hynes Alpana Pathak Constantina H Panes | 1988 | Journal of Heterocyclic Chemistry1988，25，4： | 1 |
| 15 | Analysis of Nonylphenol and Nonylphenol Ethoxylates in Sewage Sludge by High Performance Liquid Chromatography Following Microwave-assisted Extraction显示文摘 | Michalis F Panagiota D Constantina P | 2005 | J Chromatogr A2005，1089，1： | 1 |
| 16 | Analysis and Classification of Multi-Criteria Recommender Systems显示文摘 | Nikos Manouselis Constantina Costopoulou | 2007 | World Wide Web2007，00，： | 1 |
| 17 | Adalimumab for the prevention and/or treatment of post-operative recurrence of Crohn’s disease: A prospective, two-year, single center, pilot study显示文摘 | Konstantinos Papamichael Emmanuel Archavlis Constantina Lariou Gerassimos J. Mantzaris | 2012 | Journal of Crohn’s and Colitis2012，，9： | 1 |
| 18 | Frozen dough bread:Quality and textural behavior during prolonged storage-Prediction of final product characteristics 显示文摘 | Virginia Giannou Constantina Tzia | 2007 | Journal of Food Engineering2007，79，： | 1 |
| 19 | A Macro-and Micro-Examination of Family Power and Love:An Exchange Model显示文摘 | Safilios-Rothschild Constantina | 1976 | Journal of Marriage and the Family1976，，2： | 1 |
| 20 | Analysis of nonylphenol and nonylphenol ethoxylates in sewage sludge by high performance liquid chromatography following microwave-assisted extraction显示文摘 | Michalis F Panagiota D Constantina P | 2005 | Journal of Chromatography A2005，1089，12： | 1 |
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