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| 1 | Endoscopic management of esophageal varices显示文摘The rupture of gastric varices results in variceal hemorrhage, which is one the most lethal complications of cirrhosis. Endoscopic therapies for varices aim to reduce variceal wall tension by obliteration of the varix. The two principal methods available for esophageal varices are endoscopic sclerotherapy (EST) and band ligation (EBL). The advantages of EST are that it is cheap and easy to use, and the injection catheter fits through the working channel of a diagnostic gastroscope. Endoscopic variceal ligation obliterates varices by causing mechanical strangulation with rubber bands. The following review aims to describe the utility of EBL and EST in different situations, such as acute bleeding, primary and secondary | Joaquin Poza Cordon Consuelo Froilan Torres Aurora Burgos García Francisco Gea Rodriguez Jose Manuel Suárez de Parga | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 27 |
| 2 | Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets显示文摘Background: Creep feeding is used to stimulate piglet post-weaning feed consumption.L-Glutamine(GLN) is an important source of fuel for intestinal epithelial cells.The objective of this study was to determine the impact of creep feeding and adding GLN or AminoGut(AG;containing glutamine + glutamate) to pre-and post-weaning diets on pig performance and intestinal health.Litters(N = 120) were allotted to four treatments during 14–21 d of lactation: 1) No creep feed(NC,n = 45);2) creep fed control diet(CFCD,n = 45);3) creep fed 1% GLN(CFGLN,n = 15);4) creep fed.88% AG(CFAG,n = 15).After weaning,the NC and CFCD groups were sub-divided into three groups(n = 15 each),receiving either a control nursery diet(NC-CD,CFCD-CD) or a diet supplemented with either GLN(NC-GLN,CFCD-GLN) or with AG(NC-AG,CFCD-AG).Litters that were creep fed with diets containing GLN or AG also were supplemented with those amino acids in the nursery diets(CFGLN-GLN,CFAG-AG).Glutamine was added at 1% in all three post-weaning diet phases and AG was added at.88% in phase 1 and 2 and at.66% in phase 3.Results: Feed conversion(feed/gain) showed means among treatment means close to significance(P = 0.056) and Tukey's test for pairwise mean comparisons showed that Pigs in the CFGLN-GLN group had the best feed conversion(feed/gain) in the first three-week period post-weaning,exceeding(P = 0.044) controls(CFCD-CD) by 34%.The NC-AG group had(P = 0.02) the greatest feed intake in the last three week of the study,exceeding controls(CFCD-CD) by 12%.CFGLN-GLN,CFCD-GLN and sow reared(SR) pigs had the greatest(P = 0.049) villi height exceeding the CFCD-AG group by 18%,20% and 19% respectively.The CFAG-AG group had the deepest(P = 0.001) crypts among all treatments.CFGLN-GLN,CFCD-GLN and SR groups had the greatest(P = 0.001) number of cells proliferating(PCNA) exceeding those in the NC-CD group by 43%,54% and 63% respectively.Sow reared pigs showed the greatest(P = 0.001) intestinal absorption capacity for xylose and mannitol.Conclusion: Supplementation of creep feed and nursery diets with GLN and/or AminoGut in the first three week improved feed conversion possibly due to improved intestinal health. | Rafael A Cabrera James L Usry Consuelo Arrellano Eduardo T Nogueira Marianne Kutschenko Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 17 |
| 3 | Exosomes as mediators of neuron-glia communication in neuroinflammation显示文摘In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological conditions.These nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal functions.This review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous system.Special emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative disorders.Given the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and neuropathologies.Finally,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation. | María Pascual Francesc Ibánez Consuelo Guerri | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 4 | 墨西哥红豆杉愈伤组织的诱导和器官发生显示文摘 | 肖尊安 Héctor Barrios Consuelo Sandoval Garc姫a | 2000 | 植物生理学通讯2000，36，6： | 9 |
| 5 | Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease显示文摘AIM:To determine the effect of topical 0.05%cyclosporine A(CsA) on corneal endothelium in patients with dry eye disease.·METHODS:Observational,prospective,case series study.Fifty-five eyes of 29 consecutive patients(9 males and 20 females;median age:66.8 years,interquartile range:61-73.2 years) with moderate-severe dry eye disease were evaluated.All patients were treated with topical 0.05% CsA ophthalmic emulsion twice a day in addition to lubricant eyedrops 5 times a day.The followup period was 12 months.Before treatment and at 3 and12 months post-treatment central corneal specular microscopy was performed.The endothelial cell density(ECD),coefficient of variation of cell size(CoV),and percentage of hexagonal cells(Hex %) were analyzed.·RESULTS:The median ECDs pre-treatment and at 3and 12 months post-treatment were 2 352.5/mm2(interquartile range,2 178-2548.5),2 364/mm2(interquartile range,2 174.25-2 657.5),and 2 366 cells/mm2(inter-quartile range,2 174.75-2 539.75),respectively(P =0.927,one way ANOVA).The median CoVs pre-treatment and at3 and 12 months post-treatment were 34.5(interquartile range,30-37),35(interquartile range,30-38),and 34(interquartile range,30.75-38.25),respectively(P =0.7193,one way ANOVA).The median Hex % values pre-treatment and at 3 and 12 months post-treatment were53(interquartile range,47-58),54(interquartile range,45.75-59),and 50.5(interquartile range,45.75-58),respectively(P =0.824,one way ANOVA).·CONCLUSION:Treatment of patients with dry eyedisease for 12 months with topical 0.05% CsA does not seem to cause substantial changes on corneal endothelium. | Consuelo Pérez-Rico Francisco Germain María Castro-Rebollo Agustín Moreno-Salgueiro Miguel ngel Teus | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 6 |
| 6 | Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics显示文摘Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented. | Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa | 2014 | World Journal of Stem Cells2014，6，3： | 5 |
| 7 | Locally advanced rectal cancer:The importance of a multidisciplinary approach显示文摘Rectal cancer accounts for a relevant part of colorectal cancer cases,with a mortality of 4-10/100000 per year.The development of locoregional recurrences and the occurrence of distant metastases both influences the prognosis of these patients.In the last two decades,new multimodality strategies have improved the prognosis of locally advanced rectal cancer with a significant reduction of local relapse and an increase in terms of overall survival.Radical surgery still remains the principal curative treatment and the introduction of total mesorectal excision has significantly achieved a reduction in terms of local recurrence rates.The employment of neoadjuvant treatment,delivered before surgery,also achieved an improved local control and an increasedsphincter preservation rate in low-lying tumors,with an acceptable acute and late toxicity.This review describes the multidisciplinary management of rectal cancer,focusing on the effectiveness of neoadjuvant chemoradiotherapy and of post-operative adjuvant chemotherapy both in the standard combined modality treatment programs and in the ongoing research to improve these regimens. | Rossana Berardi Elena Maccaroni Azzurra Onofri Francesca Morgese Mariangela Torniai Michela Tiberi Consuelo Ferrini Stefano Cascinu | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 8 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 9 | Carbonized nano/microparticles for enhanced mechanical properties and electromagnetic interference shielding of cementitious materials显示文摘在现在的工作,碳 nano/microparticles 由花生(PS ) 的控制热分解获得了,榛子(HS ) 壳被介绍。这些材料被拉曼光谱学和地 emissionscanning 电子显微镜学(FE-SEM ) 描绘。当增加了水泥浆糊时,直到 1 wt% ,这些材料导致了水泥矩阵的增加曲折力量并且坚韧。而且关于平凡水泥,当在水泥 composites 增加 PS 或 HS 的 0.5 wt% 与相比是高得多的时,防护效果的电磁的放射的全部的增加为 CNT 在文学报导了,在一样的内容使用。 | Rao Arsalan KHUSHNOOD Sajjad AHMAD Luciana RESTUCCIA Consuelo SPOTO Pravin JAGDALE Jean-Marc TULLIANI Giuseppe Andrea FERRO | 2016 | Frontiers of Structural and Civil Engineering2016，0，2： | 4 |
| 10 | AVO分析新方法及其在西班牙Guadalquivir盆地中的应用显示文摘本文介绍了一种新的AVO方法,该方法允许解释员处理实际数据(这归因于拟3-D可视化模块),避免了单独根据地震处理技术带来的种种限制。研究区(图1)位于西班牙西南部陆上Guadalquivir盆地。该盆地是一个与Betic褶皱带和向南的逆冲断层带(活动边缘)有关的前陆盆地,它位于向北延伸的古生代稳定边缘(被动边缘)上。主要储集层是上中新统的浊积岩,砂岩平均孔隙度为20%~25%。在这一地区发现了大量的天然气。 | Consuelo García Mojonero ngela Echánove Hornos 毛宁波 | 2000 | 国外油气勘探2000，12，2： | 3 |
| 11 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 12 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours显示文摘Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing. | Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 13 | Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells显示文摘瞄准:调查一个类似的过程是否调停 cytotoxicity of1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine ( ET-18-OCH3 , edelfosine )在两酵母 andhuman 肿瘤 cells.Methods :为到由 superoxide 阴离子的 formazan 的 nitro 蓝色 tetrazolium 的 intracellularconversion 的以前描述的试金的一个修改版本被用来测量反应的氧的 thegeneration 种( ROS ) .Apoptotic 酵母细胞用 terminaldeoxynucleotidyl 被检测标记的 调停transferase 的 dUTP 刻痕结束( | Hui ZHANG Consuelo GAJATE Li-ping YU Yun-xiang FANG Faustino MOLLINEDO | 2007 | Acta Pharmacologica Sinica2007，28，6： | 2 |
| 14 | Determination of the gum Arabic–chitosan interactions by Fourier Transform Infrared Spectroscopy and characterization of the microstructure and rheological features of their coacervates显示文摘 | Hugo Espinosa-Andrews Ofelia Sandoval-Castilla Humberto Vázquez-Torres Eduardo Jaime Vernon-Carter Consuelo Lobato-Calleros | 2009 | Carbohydrate Polymers2009，，3： | 2 |
| 15 | Kinetics of the H+-ATPase from Dry and 5-Hours- Imbibed Maize Embryos in Its Native, Solubilized, and Reconstituted Forms显示文摘膜在种子萌芽在水和之上经历恢复。以前的工作描述了从玉米胚胎的血浆膜 H+-ATPase 在 0 和 5 点采用二种不同形式 ? 吸收的 h。我们调查了这二种形式的动力学怎么能被改变在血浆膜(下午) 影响。与 0-h 相比,从 5-h 的下午吸入胚胎在 glycerophospholipid 作文,在漏的减少,和流动性的增加的显示出的变化。从 0 的 PM H+-ATPase 和 5-h 的动力学吸入胚胎显示出的否定 cooperativity。与膜环境的移动,酶的活动变了到更复杂的动力学,显示二个酶部件。类脂化合物宪法与积极 cooperativity 生产了一个部件。在所有情况,从 0 的酶和 5-h 中,吸入的胚胎与一些量的差别介绍了类似的动力学。这些结果显示二种酶形式有潜在的能力在膜环境,而是事实回答他们不在 0 或 5 点在本国的膜显示出差别到变化? h 暗示在膜的修正不是足够激烈的改变他们的动力学,或他们能保存他们的边界类脂化合物或联系蛋白质并且因此保留一样的运动行为。 | Sobeida Sanchez-Nieto Consuelo Enriquez-Arredondo Fernando Guzmbn-Chavez Rolando Hern&ndez-Munoz Jorge Ramirez Marina Gavilanes-Ruiz | 2011 | Molecular Plant2011，4，3： | 2 |
| 16 | 以亚琛数字能力中心为例浅析学习工厂4.0的教学方法显示文摘工业4.0迫使企业重新审视并完善发展其商业模式与产品。无论在技术还是人才方面,企业都面临着严峻的挑战。在此,学习工厂4.0可以为企业成功地应对这些挑战提供必要的支持。亚琛数字能力中心DCC是学习工厂很好的一个示例,其教学旨在培养企业员工的数字化能力,并为企业在数字化转型的道路上给予支持。为此,该学习工厂展示的是最新的数字解决方案,并通过提供量体裁衣的工作坊和培训,使员工能够为进入全新的职业世界做好准备。 | Consuelo Leona Niemeyer Nicolina Prass | 2020 | 应用型高等教育研究2020，5，2： | 2 |
| 17 | Hepatitis B virus genotypes in the United States: results of a nationwide study显示文摘 | Chi—Jen Chu Emmet B. Keeffe Steven—Huy Han Robert P. Perrillo Albert D. Min Consuelo Soldevila-Pico William Carey Robert S. Brown Velimir A. Luketic Norah Terrault Anna S.F. Lok | 2003 | Gastroenterology2003，，2： | 1 |
| 18 | Phytate degradation by Bifidobacteriumon whole wheat fermentation显示文摘 | Mar í a Consuelo Palacios Monica Haros Yolanda Sanz | | 0，，05： | 1 |
| 19 | The Effect of Sugar Concentration and Starter Culture on Instrumental and Sensory Textural Properties of Chorizo- spanish Dry-cured Sausage 显示文摘 | Consuelo Gonz alez- Femandez Eva M Santos Jordi Rovira | 2006 | Meat Science2006，74，3： | 1 |
| 20 | Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs显示文摘 | Luis A. García Rodríguez Consuelo Huerta-Alvarez | 2001 | Epidemiology2001，，1： | 1 |
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