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| 1 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 2 | Epidemiological link between obesity,type 2 diabetes mellitus and cancer显示文摘There exists a complex interaction between obesity,type 2 diabetes mellitus(T2DM)and cancer,and an increase in the incidence of cancer is expected with the growing obesity-diabetes pandemic.The association of cancer with diabetes mellitus and obesity appears to be site-specific,the highest risk being for postmenopausal breast cancer,endometrial cancer,and colorectal cancer.Moreover,there is worsening of hyperglycaemia with the onset of cancer,evidencing a bidirectional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer survivors.In this review,we look at the epidemiological evidence from observational studies and Mendelian randomization studies linking obesity,diabetes,and cancer,as well as the complex pathophysiological mechanisms involved,including insulin resistance with associated hyperinsulinaemia,the effect of chronic low-grade inflammation,and the effect of various adipokines that are associated with obesity and T2DM.Additionally,we describe the novel therapeutic strategies,based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis. | Cornelius J Fernandez Annu Susan George Nikhila A Subrahmanyan Joseph M Pappachan | 2021 | World Journal of Methodology2021，11，3： | 2 |
| 3 | Discrepancies in the clinical and radiological profiles of COVID-19:A case-based discussion and review of literature显示文摘The current gold standard for the diagnosis of coronavirus disease-19(COVID-19)is a positive reverse transcriptase polymerase chain reaction(RT-PCR)test,on the background of clinical suspicion.However,RT-PCR has its limitations;this includes issues of low sensitivity,sampling errors and appropriate timing of specimen collection.As pulmonary involvement is the most common manifestation of severe COVID-19,early and appropriate lung imaging is important to aid diagnosis.However,gross discrepancies can occur between the clinical and imaging findings in patients with COVID-19,which can mislead clinicians in their decision making.Although chest X-ray(CXR)has a low sensitivity for the diagnosis of COVID-19 associated lung disease,especially in the earlier stages,a positive CXR increases the pre-test probability of COVID-19.CXR scoring systems have shown to be useful,such as the COVID-19 opacification rating score which helps to predict the need of tracheal intubation.Furthermore,artificial intelligence-based algorithms have also shown promise in differentiating COVID-19 pneumonia on CXR from other lung diseases.Although costlier than CXR,unenhanced computed tomographic(CT)chest scans have a higher sensitivity,but lesser specificity compared to RT-PCR for the diagnosis of COVID-19 pneumonia.A semi-quantitative CT scoring system has been shown to predict short-term mortality.The routine use of CT pulmonary angiography as a first-line imaging modality in patients with suspected COVID-19 is not justifiable due to the risk of contrast nephropathy.Scoring systems similar to those pioneered in CXR and CT can be used to effectively plan and manage hospital resources such as ventilators.Lung ultrasound is useful in the assessment of critically ill COVID-19 patients in the hands of an experienced operator.Moreover,it is a convenient tool to monitor disease progression,as it is cheap,non-invasive,easily accessible and easy to sterilise.Newer lung imaging modalities such as magnetic resonance imaging(MRI)for safe imaging among children,adolescents and pregnant women are rapidly evolving.Imaging modalities are also essential for evaluating the extra-pulmonary manifestations of COVID-19:these include cranial imaging with CT or MRI;cardiac imaging with ultrasonography(US),CT and MRI;and abdominal imaging with US or CT.This review critically analyses the utility of each imaging modality to empower clinicians to use them appropriately in the management of patients with COVID-19 infection. | Hemant Kumar Cornelius James Fernandez Sangeetha Kolpattil Mohamed Munavvar Joseph M Pappachan | 2021 | World Journal of Radiology2021，13，4： | 2 |
| 4 | Clustering cultivars into groups without rank2change interactions显示文摘 | Cornelius P L van Sanford D A Seyetsadr M S | 1992 | Crop1992，24，： | 1 |
| 5 | Reinnervation-induced alterations in rat skeletal muscle显示文摘 | Zhou Z Cornelius C P Eichner M | 2006 | Neurobiol Dis2006，23，： | 1 |
| 6 | Achieving high free electron mobility in ZnO: A1 thin films grown by reactive pulsed magnetron sputtering 显示文摘 | Cornelius S Vinnichenko M Shevchenko N | 2009 | Applied Physcis Letters2009，94，04： | 1 |
| 7 | Respon- ses of female Oriental fruit flies (Diptera: Tephritid- ae) to protein and host fruit odors in field cage and open field tests 显示文摘 | Cornelius M L Nergel L Duan J J | 2000 | Environmental Entomology2000，29，1： | 1 |
| 8 | Valproate for the treatment of acute bipolar depression:systematic review and meta-analysis显示文摘 | SMITH L A CORNELIUS V R AZORIN J M | 2010 | J Affect Disord2010，122，12： | 1 |
| 9 | Using the shifted multiplicative model to search for 'separability'in crop cultivar trials显示文摘 | Cornelius P L Seyedsatr M S Crossa J | 1992 | Theor A ppl Genet1992，84，： | 1 |
| 10 | Modification of planckblackbody radiation by photonic band-gap structures显示文摘 | Cornelius C M Dowling J P | 1999 | Phys Rev A1999，59，： | 1 |
| 11 | Effect of imidacloprid soiltreatments on occurrence of formosan subterranean termites (Isoptera :Rhinotermitidae) in independent monitors显示文摘 | OSBRINK W L CORNELIUS M L LAX A R | 2005 | J Econ Entomol2005，98，6： | 1 |
| 12 | Osteoid osteomas and osteoblastomas of the occipitocervical junction显示文摘 | Bruneau M Cornelius JF George B | 2005 | Spine2005，30，19： | 1 |
| 13 | Silica-Based Mesoporous Organic-Inorganic Hybrid Materials显示文摘 | HOFFMANN F CORNELIUS M MORELL J | 2006 | Angew Chem Int Ed2006，45，20： | 1 |
| 14 | Ion-track based single-channel templates for single-nanowire contacting显示文摘 | CHTANKO N TOIMIL-MOLARES M E CORNELIUS T W | 2005 | Nuclear Instruments and Methods in Phys-ics Research B2005，236，14： | 1 |
| 15 | Effect of age, weaning and diet on digestive enzyme levels in the piglet 显示文摘 | LINDEMANN M D CORNELIUS S G KANDELGYS M E | 1986 | Animal Science1986，62，： | 1 |
| 16 | Effect of age, weaning and diet on digestive enzyme levels in the piglet显示文摘 | LINDEMANN M D CORNELIUS S G EL KANDELGY S M | 1986 | J Anita Sci1986，62，： | 1 |
| 17 | Immunoblot analysis of proteins associated with self-assembled monolayer surfaces of defined chemistries显示文摘 | CORNELIUS R M SHANKAR S P BRASH J L etal | 2011 | J Biomed Mater Res A2011，98，1： | 1 |
| 18 | Silica-based mesoporous organic-inorganic hybrid materials 显示文摘 | Hoffmann F Cornelius M Morell J | 2006 | Angewandte Chemie-International Edition2006，45，20： | 1 |
| 19 | Integrating path dependency and path creation in a general understanding of path constitution 显示文摘 | ULI M CORNELIUS S | 2007 | Science Technology&Innovation Studies2007，3，1： | 1 |
| 20 | Effect of age,weaning anddiet on digestive enzyme level in the piglet显示文摘 | LINDEMANN M D CORNELIUS S G KANDELGY E I | 1986 | J Anim Sci1986，62，5： | 1 |
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