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| 1 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 2 | On the cyclic behaviour of new pier-to-deck connections for short-medium span composite I-girder bridges显示文摘Short-medium span steeleconcrete composite I-girder bridges are becoming more and more popular, because of the reduced construction time and costs. The light weight renders them particularly suitable also is seismic areas, even though this advantage has not been yet adequately investigated. In fact, in case of seismic loading, significant tensile forces might be exhibited at the bottom flange of the steel girder, especially when monolithic connection between deck and pier is adopted, and the connection, conceived for sustaining prevailing hogging bending moments, could experience an excessive damage.With this aim, the cyclic behaviour of new pier-to-deck joints involving the use of concrete cross-beams(CCB) has been recently analysed within the European project(SEQBRI). This paper deals with the results of a wide experimental investigation of these new joints,performed with the aim of characterizing their hysteretic behaviour. Three different typologies were tested: one designed according to the German standard DIN-FB-104, generally utilized for gravity loads only, and other two types proposed for bridges located in low(VAR-1) and medium(VAR-2) seismicity. A series of displacement-imposed cyclic tests highlighted a good seismic behaviour of all the tested solutions. In particular, the DIN-FB-104 VAR C and VAR-2 displayed a similar global behaviour in terms of maximum force and displacement, but with a more pronounced crack development and buckling of steel girders of the first solution. The VAR-2 also avoids possible pull-out phenomena in the CCB thanks to the beneficial action of pre-stressing bars.A damage analysis of the proposed connections was finally performed in view of the application of the performance-based earthquake engineering methodology and the quantification the seismic performance of this bridge typology, which was among the aims of SEQBRI project. | Fabrizio Paolacci Renato Giannini Silvia Alessandri Daniele Corritore | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，6： | 2 |
| 3 | On- Line Trust: Concepts, Evolving Themes, A Model, Int显示文摘 | CORRITORE C L BEVERLY K SUSAN W | 2003 | Human-Commputer Studies2003，58，7： | 1 |
| 4 | Signaling pathway-fo- cused gene expression profiling in pressure overloaded hearts 显示文摘 | Musumeci M Maccari S Corritore E | 2011 | Ann Ist Super Sanita2011，47，3： | 1 |
| 5 | On-line trust : concepts, evolving themes, a model显示文摘 | Corritore C L Kracher B Wiedenbeck S | 2003 | Interuational Journal of Human-Computer Studies2003，，58： | 1 |
| 6 | Development andvalidation of a scale for measuring online trust 显示文摘 | Corritore C L Kracher B | 1991 | Journal of Personality and So- cial Psychology1991，60，6： | 1 |
| 7 | On-line trust:concepts,evolving themes,a model显示文摘 | CORRITORE C L KRACHER B WIEDENBECK S | 2003 | Internation- al Journal of Human-Computer Studies2003，58，6： | 1 |
| 8 | Impact of genetic polymorphisms on the pathogenesis of idiopathic achalasia: Association with IL33 gene variant显示文摘 | Anna Latiano Orazio Palmieri Fabrizio Bossa Tiziana Latiano Giuseppe Corritore Ermelinda De Santo Giuseppina Martino Antonio Merla Maria Rosa Valvano Antonello Cuttitta Tommaso Mazza Vito Annese Angelo Andriulli | 2014 | Human Immunology2014，，： | 1 |
| 9 | On- line trust: con- eepts, wolving themes, a model 显示文摘 | Corritore C L Kraeher B Wiedenbeek S | 2003 | International Journal of Human -Computer Studies2003，58，6： | 1 |
| 10 | On-line trust: concepts, evolving themes, a model显示文摘 | Corritore C L Kracher B Wiedenbeck S | 2003 | International Journal of Human-Computer Studies2003，58，6： | 1 |
| 11 | On-line trust: concepts, evolving themes, a model显示文摘 | Cynthia L. Corritore Beverly Kracher Susan Wiedenbeck | 2003 | International Journal of Human - Computer Studies2003，，： | 1 |
| 12 | Online trust: Concepts, evolving themes, a model 显示文摘 | Corritore C Kracher B Wiedenbeck S | 2003 | International Journal of Human-Computer Studies2003，58，6： | 1 |
| 13 | On-line Trust: Concepts, Evolving Themes, a Model 显示文摘 | Corritore C L Kracher B Wiedenbeck S | 2003 | International Journal of Human-Computer Studies2003，58，6： | 1 |
| 14 | On - Line Trust: Concepts, Evolving Themes,a Model 显示文摘 | Corritore C L Kracher B Wiedenbeek S | 2003 | International Journal of Human - computer Studies2003，58，6： | 1 |
| 15 | Is there a special e-commerce ethics? 显示文摘 | Kracher B Corritore C L | 2004 | Business Ethics Quarterly2004，14，1： | 1 |
| 16 | Association study of a polymorphism in clock gene PERIOD3 and risk of inflammatory bowel disease显示文摘 | Mazzoccoli G Palmieri O Corritore G | 2012 | Chronobiol Int2012，29，8： | 1 |
| 17 | Online trust:cocepts, evolving themes,a model 显示文摘 | Corritore L Kracher B Wiedenbeck S | 2003 | Internationaljournal of human - computer stuedies2003，58，6： | 1 |
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