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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Cytosolic levels of TFF1/pS2 in breast cancer:their relationship with clinical-pathological parameters and their prognostic significance显示文摘 | Corte MD Tamargo F Alvarez A | 2006 | Breast Cancer Res Treat2006，96，1： | 1 |
| 3 | Cytosolic levels of an estrogen-induced breast cancer-associated peptide (TFF1/pS2) in colorectal cancer:clinical significance and relationship with steroid receptors显示文摘 | Vizoso FJ Fagilde MC Corte MD | 2003 | Int J Biol Markers2003，18，4： | 1 |
| 4 | Study of ma- trix metalloproteinases and their inhibitors in breast cancer显示文摘 | Vizoso FJ Gonzfilez LO Corte MD | 2007 | Br J Cancer2007，96，6： | 1 |
| 5 | Collagenase-3 ( MMP- 13) expression in cutaneous malignant melanoma显示文摘 | Corte MD Gonzalez LO Corte MG | 2005 | Int J Biol Markers2005，20，4： | 1 |
| 6 | Expression and clinicalsignificance of CD44v5 and CD44v6 in resectable colorectal cancer显示文摘 | Vizoso FJ Fernández JC Corte MD | 2004 | J Cancer Res Clin Oncol2004，130，11： | 1 |
| 7 | Clinical significance of cathepsin Dconcentration in tumor cytosol of primary breast cancer显示文摘 | Rodroguez J Vazquez J Corte MD | 2005 | Int J Biol Markers2005，20，： | 1 |
| 8 | Androgen receptor expresion in breast cancer:relationship with clinicopathological characteristics of the tumors,prognosis, and expression of metalloproteases and their inhibitors显示文摘 | Gonzalez LO Corte MD Vazquez J | 2008 | BMC Cancer2008，8，： | 1 |
| 9 | Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer显示文摘 | Vizoso FJ Fernandez JC Corte MD | 2004 | J Cancer Res Clin Oncol2004，130，11： | 1 |
| 10 | Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma显示文摘 | Gonz/dez LO Corte MD Junquera S | 2009 | Hum Pathol2009，40，9： | 1 |
| 11 | Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance显示文摘 | del Casar JM Corte MD Alvarez A | 2008 | J Cancer Res Clin Oncol2008，134，： | 1 |
| 12 | Collagenase - 3 expression in cutaneous malignant melanoma显示文摘 | Gort MD Conzallez LO Corte MG | 2005 | Int J Biol Markers2005，20，4： | 1 |
| 13 | Membranous levels of cerbB-2 oncoprotein in gastric cancer: their relationship with clinic opathological parameters and their prognostic significance 显示文摘 | Vizoso FJ Corte MD Alvarez A | | Int J BiolMarkers0，19，4： | 1 |
| 14 | Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer显示文摘 | Rodriguez J Vazquez J Corte MD | 2005 | Int J Biol Markers2005，20，2： | 1 |
| 15 | Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and prpsiongen C) in ductal carcinoma in situ of the breast显示文摘 | LO Gonzalez MD Corte S Junquera | 2007 | Histopathology2007，50，： | 1 |
| 16 | Labat法坐骨神经阻滞下局部麻醉药低容量高浓度较高容量低浓度更有效:一项前瞻性随机对照研究显示文摘背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率,本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时,单剂量的甲哌卡因300mg分别稀释至20和30ml注射后的阻滞效果差异。方法90例行足部手术的患者,随机分为2组接受坐骨神经阻滞,一组给予1.5%甲哌卡因20m1(45例),另一组给予1%甲哌卡因30m1(45例),所有阻滞均在神经刺激仪定位下进行(参数为刺激频率2Hz;刺激电流为1.5~0.5mA)。两组中,神经刺激反应在〈0.5mA时引出,亦可以定向诱发足部肌肉向跖侧屈曲,分别记录胫神经和腓总神经的运动感觉功能被阻滞的起效时间。而坐骨神经支配区域的针刺感觉消失,同时足部跖曲及背曲运动消失为阻滞成功的标准。结果用20ml的1.5%甲哌卡因组阻滞成功率(96.6%)显著高于30ml的1%甲哌卡因组(68.9%,P〈0.05)。而前者达到感觉与运动完全阻滞所需要的时间(11±6分钟,13±7分钟)也短于后者(17±8分钟,19±8分钟,P〈0.05)。结论Labat法行坐骨神经阻滞时,与高容量低浓度的局部麻醉药(1%甲哌卡因)比较,使用低容量高浓度的局部麻醉药(1.5%甲哌卡因)能够获得更高的阻滞成功率及更短的起效时间。 | Manuel Taboada Muniz, MD, PhD Jaime Rodriguez, MD, PhD Maria Bermudez, MD Cristina Valino, MD Noemi Blanco, MD Marcos Amor, MD Pilar, Aguirre, MD Ana Masid, MD Joaquin Cortes, MD, Ph Julian Alvarez, MD, PhD Peter G. Atanassoff, MD 杨光(译) 崔苏扬(校) | 2010 | 麻醉与镇痛2010，，2： | 1 |
| 17 | Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer显示文摘 | Vizoso FJ Fernández JC Corte MD | | 0，，11： | 1 |
| 18 | Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer显示文摘 | Vizoso FJ Ferhandez JC Corte MD | 2004 | J Cancer Res Clin Oncol2004，130，11： | 1 |
| 19 | Lymphatic and/or blood vessel invasion in gastric cancer:relationship with clinicopathological parameters,biological factors and prognostic significance显示文摘 | del Casar JM Corte MD Alvarez A | 2008 | J Cancer Res Clin Oncol2008，134，2： | 1 |
| 20 | Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma显示文摘 | Gonzalez LO Corte MD Junquera S | 2009 | Hum Pathol2009，40，9： | 1 |
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