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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation显示文摘AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal inflammation.METHODS The animals were divided into groups that received vehicle or P.angulata extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS damage.Protective effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)microscopy.RESULTS PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil infiltration.These effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control animals.In addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural analysis.CONCLUSION Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease. | luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz Claudio Di Stasi | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 3 | Endocrine factors modulating immune responses in pregnancy 显示文摘 | Schumacher A Costa SD Zenclussen AC | 2014 | Front Immunol2014，5，： | 1 |
| 4 | A simple method of evaluating delayed typed hypersensitivity in mice显示文摘 | Corsini AC Bellucci S B Costa MG | 1979 | J Immunol Methods1979，30，： | 1 |
| 5 | The effect of nitrous oxide on the inhibition of somatosensory evoked potentials by sevoflurane in children显示文摘 | da Costa VV Saraiva RA de Almeida AC | 2001 | Anesthesia2001，56，3： | 1 |
| 6 | Sustained suppression of neointimal proliferation by sirolimus eluting stents: one year angiographic and intravascular ultrasound follow up 显示文摘 | Sousa JE Costa MA Abizaid AC | 2001 | Circulation2001，104，： | 1 |
| 7 | Assessment of disease activity in treated acromegalic patients using a sensitive GH assay:Should we achieve strict normal GH levels for a biochemical cure? 显示文摘 | Costa AC Rossi A Martinelli CE | 2002 | J Clin Endocri Metab2002，87，7： | 1 |
| 8 | The early and midterm function of decellularized aortic valve allografts显示文摘 | da Costa FD Costa AC Prestes R | 2010 | Ann Thorac Surg2010，90，6： | 1 |
| 9 | Sustained suppression of neointimal proliferation by sirolimus - eluting stents : one - year angiographic and intravascular ultrasound follow - up 显示文摘 | Sousa JE Costa MA Abizaid AC | 2001 | Circulation2001，104，17： | 1 |
| 10 | Variables associated with extra uterine growth restriction in very low birth weight infants显示文摘 | Lima PA Carvalho MD Costa AC | 2014 | J Pediatr2014，90，1： | 1 |
| 11 | Pathogenesis of Helicobacterpylori infection显示文摘 | Costa AC Figueiredo C Touati E | 2009 | Helicobacter2009，14，1： | 1 |
| 12 | Lack of neointimal proliferation after implantation of sirolimus-coated stent in human coronary arteries:a quantitative coronary angiography and threedimensional intravascular ultrasound study显示文摘 | Sousa JE Costa MA Abizaid AC | 2001 | Circulation2001，10，： | 1 |
| 13 | Drug eluting stents in the elderly: long-term clinical outcomes of octogenarians in the DESIRE (Drug-Eluting Stents In the REal world) registry显示文摘 | Costa JR Sousa A Moreira AC | 2008 | J Invasive Cardiol2008，20，4： | 1 |
| 14 | PI3K Regulates MEK/ERK signaling in breast cancer via the Rac-GEF,P-Rex1显示文摘 | Ebi H Costa C Faber AC Nishtala M Kotani H Juric D | 2013 | Proc Natl Acad Sci USA2013，110，21： | 1 |
| 15 | A simple method of evaluating delayed type hypersensitivity in mice显示文摘 | Corsini AC Bellucci SB Costa MG | 1979 | J Immunol Methods1979，30，： | 1 |
| 16 | Variables associated with extra uterine growth restriction in very low birth weight infants显示文摘 | Lima PA de Carvalho Md da Costa AC | 2014 | J Pediatr:Rio J2014，90，1： | 1 |
| 17 | Variables associated with ext-ra uterine growth restriction in very low birth weight infants显示文摘 | Lima PA Carvalho M Costa AC | 2014 | J Pediatr2014，90，1： | 1 |
| 18 | Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries显示文摘 | Sousa JE Costa MA Sousa AG Abizaid AC Seixas AC Abzaid AS | 2003 | Circulation2003，107，3： | 1 |
| 19 | Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries:a quantitative coronary angiography and three-dimensional intravascular ultrasound study显示文摘 | Costa MA Abizaid AC | 2001 | Circulation2001，103，2： | 1 |
| 20 | A simple method of evalua- ting delayed type hypersensitivity in mice 显示文摘 | Corsini AC Bellucci SB Costa MG | 1979 | J Inununol Method1979，30，2： | 1 |
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