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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | Study in non-pressure-treated versus pressure-treated hypertrophic scars显示文摘 | Costa AM Peyrol S Porto LC Mechanical forces induce scar remodeling | 1999 | Am J Pathol1999，155，5： | 1 |
| 4 | Candida bloodstream infection:data from a teaching hospital in Mato Grosso do Sul,Brazil显示文摘 | Chang MR Correia FP Costa LC | 2008 | Rev Inst Med Trop Sao Paulo2008，50，5： | 1 |
| 5 | Immunolabeling of type IV collagen, laminin, and alpha-smooth muscleactin ceils in the intima of normal and varicose saphenous veins 显示文摘 | Porto LC Ferreira MA Costa AM | 1998 | Angiology1998，49，： | 1 |
| 6 | Neurotoxicity of pesti-cides: a brief review显示文摘 | Costa LC Giordano G Guizzetti M | 2008 | J Front Bi^ci2008，13，： | 1 |
| 7 | Use of ash forest biomass combustion as acidity correction and fertility of a humic cambisol显示文摘 | Silva FR da Albuquerque JA Gatiboni LC Costa A da | 2013 | Revista de Ciencias Agroveterinarias2013，12，3： | 1 |
| 8 | Effect of the number of thermocycles on microleakage of resin composite restorations显示文摘 | Pazinatto FB Campos BB Costa LC | 2003 | Pesqui Odontol Bras2003，17，4： | 1 |
| 9 | Detection of paraquat in oral fluid, plasma, and urine by capillary electrophoresis lot diagnosis of acute poisoning显示文摘 | Lanaro R Costa JL Fernandes LC | 2011 | J Anal Toxico12011，35，： | 1 |
| 10 | Analysis of sun radiation use efficiency for soy bean,maize,rice and bean crops on various producers regions of Minas Gerais,Brazil显示文摘 | Costa LC Santos AA Dos | 2000 | Agric Jaboticabal2000，20，3： | 1 |
| 11 | Maternal near miss in the intensive care unit: clinical and epidemiological aspects显示文摘 | Oliveira LC Costa AA | 2015 | Rev Bras Ter Intensiva2015，27，3： | 1 |
| 12 | Detection of paraquat in oral fluid,plasma,and urine by capillary electrophoresis for diagnosis of acute poisoning显示文摘 | Lanaro R Costa JL Fernandes LC | 2011 | J Anal Toxicol2011，35，： | 1 |
| 13 | A 38-year-old man with tra- cheomegaly,tracheal diverticulosis,and bronchiectasis 显示文摘 | Lazzarini-de-Oliveira LC Costa de Barros Franco CA Gomes de Salles CL | 2001 | Chest2001，120，3： | 1 |
| 14 | Candida bloodstream infection:data from a teaching hospital in Mato Grosso do Sul,Brazil显示文摘 | Chang MR Correia FP Costa LC | 2008 | Rev Inst Med Trop Sao Paulo2008，50，5： | 1 |
| 15 | Mechanical forces induce scar remodeling:study in non-pressure-treated versus pressure-treated hypertrophic scars显示文摘 | Costa AM Peyrol S Porto LC | 1999 | Am J Pathol1999，155，5： | 1 |
| 16 | Meniere'disease:overview, epdemiology,and nature history显示文摘 | Costa SS Sousa LC Piza MR | 2002 | Otolaryngol Clin North Am2002，35，3： | 1 |
| 17 | Candida bloodstream infection:data from a teachinghospital in Mato Grosso do Sul,Brazil显示文摘 | Chang MR Correia FP Costa LC Xavier PC Palhares DB Tai-ra DL | 2008 | Rev Inst Med Trop SaoPaulo2008，50，5： | 1 |
| 18 | A 38-year-old man with tracheomegaly, tracheal, diverticulosis, and hronehieetasis 显示文摘 | Lazzarini-de-Oliveira LC Costa de Barros Franco CA Gomes de Salles CL | 2001 | Chest2001，120，3： | 1 |
| 19 | Candida blood-stream infection:data from a teaching hospital in Mato Grosso do Sul,Brazil显示文摘 | Chang MR Correia FP Costa LC | 2008 | Rev Inst Med Trop Sao Paulo2008，50，5： | 1 |
| 20 | Meniere's disease:overview, epidemiology,and natural history显示文摘 | Costa SS Sousa LC | 2002 | Otolaryngol Clin North Am2002，35，： | 1 |
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