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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Relation of C - reactive protein to ox- idative stress and to endothelial activation in essentia lhypertension 显示文摘 | Cottone S MuI~ G Nardi E | 2006 | Am J Hypertens2006，19，3： | 1 |
| 3 | Prehospital Intravenous Fluid Administration Is Associated With Higher Mortality in Trauma Patients: A National Trauma Data Bank Analysis显示文摘 | Haut E R Kalish B T Cotton B A | 2011 | Annals of Surgery2011，253，2： | 1 |
| 4 | Microalbuminuria and early endothelial activation in essential hypertension显示文摘 | Mule G Nardi E | 2007 | J Hum Hypertens2007，21，： | 1 |
| 5 | Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension显示文摘 | Cottone S Mule G Nardi E | 2006 | Am J Hypertens2006，19，3： | 1 |
| 6 | Relation of C - reative protein to oxidative stress and to endothelial activation in essential hypertension 显示文摘 | Cottone S Mule G Nardi E | 2006 | Am J Hypertens2006，19，3： | 1 |
| 7 | Assessment of a hiuret meth- od without concentration step for total protein determination in cerebrospinalfluid显示文摘 | Cotton F Delobbe E Gulbis B | 1997 | Clinical Biochemistry1997，30，4： | 1 |
| 8 | Infection after ERCP,and antibi- otic prophylaxis:a sequential quality-improvement approach over 11 years 显示文摘 | Cotton PB Connor P Rawls E | 2008 | Gastrointest Endosc2008，67，3： | 1 |
| 9 | Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1显示文摘 | Carlson J M Brumme C J Martin E Listgarten J Brockman M A Le A Q Chui C K Cotton L A Knapp D J Riddler S A Haubrich R Nelson G Pfeifer N Deziel C E Heckerman D Apps R Carrington M Mallal S Harrigan P R John M Brumme Z L International HIV Adaptation Collaborative | 2012 | J Virol2012，86，13： | 1 |
| 10 | Analysis of genomic rearrangement and subsequent gene deletion of the attenuated Orf virus strain D1701 显示文摘 | Cottone R Büttner M Bauer B Henkel M Hettich E Rziha HJ | 1998 | Virus Res1998，56，1： | 1 |
| 11 | The Hydrodynamic Effects of Single Phase Flow on Flow Accelerated Corrosion in a 90-degree Elbow显示文摘 | Gammal M E Mazhar H Cotton J S | 2010 | Nu- clear Engineering and Design2010，，240： | 1 |
| 12 | Relation of C-reactive protein to exidative stress and to endothelial activation in essential hypertension显示文摘 | Cottone S Mule G Nardi E | 2006 | Am J Hypertens2006，19，3： | 1 |
| 13 | Microalbu- minuria and early endothelial activation in essential hypertension显示文摘 | COTTONE S MULE G NARDI E | 2007 | J Hum Hypertens2007，21，： | 1 |
| 14 | Microalbuminufia and early endothelial activation in essential hypertension 显示文摘 | Cottone S Mule G Nardi E | 2007 | J Hum Hypertens2007，21，2： | 1 |
| 15 | Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hyper-tension显示文摘 | Cottone S Mule G Nardi E | 2006 | Am J Hypertens2006，19，3： | 1 |
| 16 | Clinical presentation and outcome of tuberculosis in human immunodeficiency virus infected children on anti-retroviral therapy 显示文摘 | Waiters E Cotton M F Rabie H | 2008 | BMC Pediatr2008，8，： | 1 |
| 17 | Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6显示文摘 | Cotton JM Hong Y Hawe E | 2003 | Thromb Haemost2003，89，3： | 1 |
| 18 | Relation of C- reactive protein to oxidative stress and to endothelial activation in essential hypertension 显示文摘 | Cottone S Mule G Nardi E | 2006 | Am J Hyper- tense2006，19，3： | 1 |
| 19 | Metabolic syndrome in subjects with essential hypertension: relationships with subclinical eardiovaseular and renal damage 显示文摘 | Mule G Cottone S Nardi E | 2006 | Minewa Cardioangiologica2006，54，2： | 1 |
| 20 | Infection after ERCP, an(/ antibiotic prophylaxis: a sequential quality-improvement approach over 11 years 显示文摘 | Cotton PB Connor P Rawls E | 2008 | Gastrointest Endosc2008，67，3： | 1 |
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