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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis显示文摘 | Kurt Degenhardt Robin Mathew Brian Beaudoin Kevin Bray Diana Anderson Guanghua Chen Chandreyee Mukherjee Yufang Shi Céline Gélinas Yongjun Fan Deirdre A. Nelson Shengkan Jin Eileen White | 2006 | Cancer Cell2006，，1： | 2 |
| 5 | Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]显示文摘 | Angela L. McCleary-Wheeler Gwen A. Lomberk Frank U. Weiss Günter Schneider Muller Fabbri Tara L. Poshusta Nelson J. Dusetti Sandra Baumgart Juan L. Iovanna Volker Ellenrieder Raul Urrutia Martin E. Fernandez-Zapico | 2013 | Cancer Letters2013，，1： | 2 |
| 6 | The effect of non-normality on the control limits of X charts 显示文摘 | Schilling E G Nelson P R | 1976 | Journal of Quality Technology1976，8，2： | 1 |
| 7 | Entrepreneurship Research in Emergence:Past Trends and Future Directions显示文摘 | BUSENITZ L W WEST G F SHEPHERD D NELSON T CHANDLER G N ZACHARAKIS A | 2003 | Journal of Management2003，29，3： | 1 |
| 8 | The role of hepatitis C virus-specific cytotoxic T-lymphocytes in chronic hepatitis C显示文摘 | Marousis C G Davis G L | 1997 | J Immunol1997，158，： | 1 |
| 9 | Nodular pulmonary 显示文摘 | Nelson D G Pearsall G F etal | 1997 | G Thorac Cardiovasc Surg1997，114，2： | 1 |
| 10 | Endothelin-1 inhibits apoptosis in prostate cancer显示文摘 | Nelson JB Udan MS Guruli G | 2005 | Neoplasia2005，7，7： | 1 |
| 11 | Adaptations to environmental stresses显示文摘 | Hans J Bohnert Nelson D E Jensen R G | 1995 | Plant cell1995，7，： | 1 |
| 12 | 显示文摘 | Benrashid R Nelson G L Linn J H | 1993 | Journal of Applied Polymer Science1993，49，： | 1 |
| 13 | High sensitivity surface plasmon resonance sensor based on phase detection显示文摘 | Nelson S G Johnston KS Yee S S | 1996 | Sensors and actuators B1996，3536，： | 1 |
| 14 | Redistribution of collateral blood flow from necrotic to surviving myocardium following coronary occlusion in the dog 显示文摘 | Hirzel H O Nelson G R Sormenblick E H | 1976 | Circ Res1976，39，： | 1 |
| 15 | The contribution of shared knowledge to is group performance 显示文摘 | NELSON K M COOPRIDER J G | 1996 | MIS Quarterly1996，20，： | 1 |
| 16 | Vascular lesions in pigs experimentally infected with porcine circovirus type 2 serogroup B显示文摘 | Langohr I M Stevenson G W Nelson E A | 2010 | Vet Pathol2010，47，1： | 1 |
| 17 | Phytoalexin-like activity of abietic acid and its derivatives显示文摘 | Spessard G O Matthews D R Nelson M D | 1995 | Journal of Agricultural and Food Chemistry1995，43，6： | 1 |
| 18 | Preservicing mission,on-orbit modifications to Hub-ble space telescope pointing control system显示文摘 | NURRE G S SHARKEY J P NELSON J J | 1995 | Jour-nal of Guidance Control and Dynamics1995，18，2： | 1 |
| 19 | Eraser:A dynamic data race detector for multithreaded programs 显示文摘 | Savage S Burrows M Nelson G | 1997 | ACM Transactions on Computer Systems (TOCS)1997，15，39： | 1 |
| 20 | Land Use and Decision- making for National Parks and Protected Areas 显示文摘 | Nelson G Serafin R Skibicki A | 1997 | NATO ASI Series1997，40，： | 1 |
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