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| 1 | Radiation exposure and reduction in the operating room: Perspectives and future directions in spine surgery显示文摘Intraoperative imaging is vital for accurate placement of instrumentation in spine surgery. However, the use of biplanar fluoroscopy and other intraoperative imaging modalities is associated with the risk of significant radiation exposure in the patient, surgeon, and surgical staff. Radiation exposure in the form of ionizing radiation can lead to cellular damage via the induction of DNA lesions and the production of reactive oxygen species. These effects often result in cell death or genomic instability, leading to various radiation-associated pathologies including an increased risk of malignancy. In attempts to reduce radiation-associated health risks, radiation safety has become an important topic in the medical field. All practitioners, regardless of practice setting, can practice radiation safety techniques including shielding and distance to reduce radiation exposure. Additionally, optimization of fluoroscopic settings and techniques can be used as an effective method of radiation dose reduction. New imaging modalities and spinal navigation systems have also been developed in an effort to replace conventional fluoroscopy and reduce radiation doses. These modalities include Isocentric Three-Dimensional C-Arms, O-Arms, and intraoperative magnetic resonance imaging. While this influx of new technology has advanced radiation safety within the field of spine surgery, more work is still required to overcome specific limitations involving increased costs and inadequate training. | Ankur S Narain Fady Y Hijji Kelly H Yom Krishna T Kudaravalli Brittany E Haws Kern Singh | 2017 | World Journal of Orthopedics2017，8，7： | 9 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | An analysis of multiple staging management strategies for carcinoma of the esophagus: computed tomography, endoscopic ultrasound, positron emission tomography, and thoracoscopy/laparoscopy显示文摘 | Michael B Wallace Paul J Nietert Craig Earle Mark J Krasna Robert H Hawes Brenda J Hoffman Carolyn E Reed | 2002 | The Annals of Thoracic Surgery2002，，4： | 2 |
| 4 | Development of constitutive relationships using compression testing of a medium carbon steel 显示文摘 | Rao K P Haw bolt E B | 1992 | Transactions of the ASME Journal of Engineering Materials and Technology1992，114，： | 1 |
| 5 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 6 | ADH levels following nonhypotensive hemorrhage in dogs with chronic mireal stenosis显示文摘 | Zehr J E Hawe A Tsakiris A G | 1971 | Am J Physiol1971，221，1： | 1 |
| 7 | Non-fasting apolipoprotein B and tri- glyceride levels as a useful predictor of coronary heart disease risk in middle- aged UL men显示文摘 | Talmud PJ Hawe E Miller GJ | 2002 | Arterioscler Thromb Vasc Biol2002，22，11： | 1 |
| 8 | Fecalincontinence :prevalence,severity,and quality of life data from an outpatientgastroenterology practice 显示文摘 | ALSHEIK E H COYNE T HAWES SK | 2012 | Gastroenterol Res Pract2012，，94： | 1 |
| 9 | Inheritance of resistance to Fusarium Sulphureum 显示文摘 | Lees A K Brads haw J E | 2001 | Potato Research2001，44，2： | 1 |
| 10 | Toward a systematic chemistry of organic reactions in zeolites:in situ NMR studies of ketones显示文摘 | Xu T Munson E J Haw J F | 1994 | J Am Chem Soc1994，116，： | 1 |
| 11 | An in situ solid-state study of the formation and reactivity of trialkylonium ions in zeolites 显示文摘 | Munson E J Khier Haw J F | 1993 | J Phys Chem1993，，97： | 1 |
| 12 | Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe显示文摘 | Abuzeid AM Hawe E Humphries SE | 2003 | Atherosclerosis2003，168，： | 1 |
| 13 | Microsomal formation of apyrrolic alcohol glutathione conjugate of clivorine,Firmevidence for the form ation of a pyrrolic metabolite of anotonecine-type pyrrolizidine al- kaloid显示文摘 | LING CUI YY HAWES E M | 1998 | Drug Metab Dispos1998，26，2： | 1 |
| 14 | The identification of vagi- nal Lactobacillus species and the demographic and microbiologic char- acteristics of women colonized by these species 显示文摘 | ANTONIO M A HAWES S E HILLIER S L | 1999 | J Infect Dis1999，180，6： | 1 |
| 15 | An in situSolid-State study of the formation and reactivity of trial-kylonium Ions in zeolites显示文摘 | Munson E J Khier A A Haw J F | 1993 | J Phys Chem1993，97，： | 1 |
| 16 | Relative contri- bution of variation within the APOCa/A4/A5 gene cluster in determining plasma triglycerides显示文摘 | Talmud P J Hawe E Martin S | 2002 | Hum Mol Gen2002，24，11： | 1 |
| 17 | NMR observation of trimethyloxonium formation from dimethyl ether on zeolite HZSM-5显示文摘 | MUNSON E J HAW J F | 1991 | J Am Chem Soc1991，113，16： | 1 |
| 18 | In situ solid-state NMR study of methanol-to-gasoline chemistry in zeolite HZSM-5 显示文摘 | MUNSON E J KHEIR A A LAZO N D HAW J F | 1992 | J Phys Chem1992，96，19： | 1 |
| 19 | The thermal and metallurgical state strip during hot rolling:part Ⅲ (Microstructural evolution)显示文摘 | Devadas C Samarasekera I V Haw bolt E B | 1991 | Metal Trans A1991，22，： | 1 |
| 20 | Development of constitutive relationships using compression testing of a medium carbonsteel显示文摘 | Rao K P Haw bolt E B | 1992 | Journal of Engineering Materials and Technology1992，114，1： | 1 |
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